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(MIP-1) and MIP-1ß Chemokine Production in Human B Cells1
Institut National de la Santé et de la Recherche Médicale, Unit 131, Institut Paris-Sud sur les Cytokines, Clamart, France
We show herein that B cell Ag receptor (BCR) triggering, but not
stimulation by CD40 mAb and/or IL-4, rapidly induced the coordinated
expression of two closely related T cell chemoattractants, macrophage
inflammatory protein-1ß (MIP-1ß) and MIP-1
, by human B cells.
Naive, memory, and germinal center B cells all produced MIP-1/ß in
response to BCR triggering. In contrast to MIP-1/ß, IL-8, which is
spontaneously produced by germinal center B cells but not by naive and
memory B cells, was not regulated by BCR triggering. Culturing
follicular dendritic cell-like HK cells with activated B cells did not
regulate MIP-1/ß production, but it did induce production of IL-8
by HK cells. Microchemotaxis assays showed that
CD4+CD45RO+ T cells of the effector/helper
phenotype actively migrated along a chemotactic gradient formed by
BCR-stimulated B cells. This effect was partially blocked by
anti-MIP-1ß and anti-CC chemokine receptor 5 Ab, but not by
anti-MIP-1 Ab suggesting that MIP-1ß plays a major role in
this chemoattraction. Since maturation of the B cell response to a
peptide Ag is mostly dependent on the availability of T cell help, the
ability of Ag-stimulated B cells to recruit T cells via MIP-1/ß,
may represent one possible mechanism enabling cognate interactions
between rare in vivo Ag-specific T and B cells.
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