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Cutting Edge: Phorbol Ester Induction of IFN- Receptors Leads to Enhanced DR Gene Expression

Laboratory of Molecular Biology, Medical Research Center, Kochi Medical School, Kochi, Japan

We observed that IFN--inducible expression of the DR gene was enhanced when THP-1 cells are differentiated into macrophage-like cells by phorbol ester treatment. Here, we observed that class II MHC trans-activator and STAT1 mRNA, mediators of the signaling cascade from the IFN- receptor to the DR induction, were markedly increased by IFN- stimulation in phorbol ester-activated THP-1 cells; however, both mRNAs were not increased by phorbol ester treatment alone. Then, we demonstrated that the mRNA and proteins of the IFN- receptor - and ß-chains were amplified by phorbol ester treatment in THP-1 cells. Consequently, these results indicate that the enhancement of DR gene expression by IFN- treatment in phorbol ester-activated THP-1 cells is due to the phorbol ester-induced up-regulation of IFN- receptor - and ß-chains. As a result, the amplification of STAT1 and the increment of class II MHC trans-activator results in enhancement of DR expression.

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