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Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
Increased expression of the low affinity receptor for IgE,
Fc
RII/CD23 has been observed in rheumatoid arthritis. In view of
this, we have investigated the expression and influence of CD23 in
collagen-induced arthritis (CIA), an animal model for rheumatoid
arthritis. CD23+ cells were analyzed in lymph nodes of
DBA/1 mice immunized with bovine collagen type II (BCII) in CFA or with
CFA only. The percentage of CD23+ lymph node cells was
increased in both BCII/CFA- and CFA-immunized mice at 1, 3, and 7 wk
after immunization compared with unimmunized mice, indicating a role
for the adjuvant to trigger general inflammation and CD23 expression.
To investigate the functional role of CD23 in CIA, CD23-deficient mice
on the DBA/1 genetic background were studied. After immunization with
BCII/CFA, these mice developed CIA with delayed onset and reduced
severity compared with wild-type mice. These findings suggest that an
increased number of CD23+ cells is part of an inflammatory
response and that CD23 expression is of pathogenic importance in the
arthritic process.
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