| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206
Viral respiratory infections can cause bronchial
hyperresponsiveness and exacerbate asthma. In mice, respiratory
syncytial virus (RSV) infection results in airway hyperresponsiveness
(AHR) and eosinophil influx into the airways. The immune cell
requirements for these responses to RSV infection are not well defined.
To delineate the role of CD8 T cells in the development of RSV-induced
AHR and lung eosinophilia, we tested the ability of mice depleted of
CD8 T cells to develop these symptoms of RSV infection. BALB/c mice
were depleted of CD8 T cells using anti-CD8 Ab treatment before
intranasal administration of infectious RSV. Six days postinfection,
airway responsiveness to inhaled methacholine was assessed by
barometric body plethysmography, and numbers of lung eosinophils and
levels of IFN-
, IL-4, and IL-5 in bronchoalveolar lavage fluid were
monitored. RSV infection resulted in airway eosinophilia and AHR in
control mice, but not in CD8-depleted animals. Further, whereas
RSV-infected mice secreted increased amounts of IL-5 into the airways
as compared with noninfected controls, no IL-5 was detectable in both
bronchoalveolar lavage fluid and culture supernatants from CD8-depleted
animals. Treatment of CD8-depleted mice with IL-5 fully restored both
lung eosinophilia and AHR. We conclude that CD8 T cells are essential
for the influx of eosinophils into the lung and the development of AHR
in response to RSV infection.
This article has been cited by other articles:
|
|
 |
|
  A. Joetham, K. Takeda, M. Okamoto, C. Taube, H. Matsuda, A. Dakhama, and E. W. Gelfand Antigen Specificity Is not Required for Modulation of Lung Allergic Responses by Naturally Occurring Regulatory T Cells J. Immunol., August 1, 2009; 183(3): 1821 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. G. Bhoj, Q. Sun, E. J. Bhoj, C. Somers, X. Chen, J.-P. Torres, A. Mejias, A. M. Gomez, H. Jafri, O. Ramilo, et al. MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus PNAS, September 16, 2008; 105(37): 14046 - 14051. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wehling-Henricks, S. Sokolow, J. J. Lee, K. H. Myung, S. A. Villalta, and J. G. Tidball Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy Hum. Mol. Genet., August 1, 2008; 17(15): 2280 - 2292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Tregoning, Y. Yamaguchi, J. Harker, B. Wang, and P. J. M. Openshaw The Role of T Cells in the Enhancement of Respiratory Syncytial Virus Infection Severity during Adult Reinfection of Neonatally Sensitized Mice J. Virol., April 15, 2008; 82(8): 4115 - 4124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, N. Peters, and J. Schwarze Plasmacytoid Dendritic Cells Limit Viral Replication, Pulmonary Inflammation, and Airway Hyperresponsiveness in Respiratory Syncytial Virus Infection J. Immunol., November 1, 2006; 177(9): 6263 - 6270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. C. Davis, E. R. Lazarowski, J. M. Hickman-Davis, J. A. Fortenberry, F.-P. Chen, X. Zhao, E. Sorscher, L. M. Graves, W. M. Sullender, and S. Matalon Leflunomide Prevents Alveolar Fluid Clearance Inhibition by Respiratory Syncytial Virus Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 673 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Herd, S. Mahalingam, I. M. Mackay, M. Nissen, T. P. Sloots, and R. W. Tindle Cytotoxic T-Lymphocyte Epitope Vaccination Protects against Human Metapneumovirus Infection and Disease in Mice J. Virol., February 15, 2006; 80(4): 2034 - 2044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. J. van Rensen, J. K. Sont, C. E. Evertse, L. N. A. Willems, T. Mauad, P. S. Hiemstra, P. J. Sterk, and the AMPUL Study Group Bronchial CD8 Cell Infiltrate and Lung Function Decline in Asthma Am. J. Respir. Crit. Care Med., October 1, 2005; 172(7): 837 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. O'Sullivan Asthma Death, CD8+ T Cells, and Viruses Proceedings of the ATS, August 1, 2005; 2(2): 162 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Bramley, M. A. Khan, H. E. Manson, and R. G. Hegele Development of Respiratory Syncytial Virus "Bronchiolitis" in Guinea Pigs Does Not Reflect an Allergic Predisposition in the Host Chest, August 1, 2003; 124(2): 671 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Adamko, A. D. Fryer, B. S. Bochner, and D. B. Jacoby CD8+ T Lymphocytes in Viral Hyperreactivity and M2 Muscarinic Receptor Dysfunction Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 550 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Culley, J. Pollott, and P. J.M. Openshaw Age at First Viral Infection Determines the Pattern of T Cell-mediated Disease during Reinfection in Adulthood J. Exp. Med., November 18, 2002; 196(10): 1381 - 1386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Rha, C. Taube, A. Haczku, A. Joetham, K. Takeda, C. Duez, M. Siegel, M. K. Aydintug, W. K. Born, A. Dakhama, et al. Effect of Microbial Heat Shock Proteins on Airway Inflammation and Hyperresponsiveness J. Immunol., November 1, 2002; 169(9): 5300 - 5307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schwarze and E.W. Gelfand Respiratory viral infections as promoters of allergic sensitization and asthma in animal models Eur. Respir. J., February 1, 2002; 19(2): 341 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Krug, V. J. Erpenbeck, K. Balke, J. Petschallies, T. Tschernig, J. M. Hohlfeld, and H. Fabel Cytokine Profile of Bronchoalveolar Lavage-Derived CD4+, CD8+, and gamma delta T Cells in People with Asthma after Segmental Allergen Challenge Am. J. Respir. Cell Mol. Biol., July 1, 2001; 25(1): 125 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. DOUGLASS and R. E. O'HEHIR What Determines Asthma Phenotype? . Respiratory Infections and Asthma Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): S211 - 214. [Full Text] [PDF]
|
|
|
|
|
|
J. Schwarze, M. Makela, G. Cieslewicz, A. Dakhama, M. Lahn, T. Ikemura, A. Joetham, and E. W. Gelfand Transfer of the Enhancing Effect of Respiratory Syncytial Virus Infection on Subsequent Allergic Airway Sensitization by T Lymphocytes J. Immunol., November 15, 1999; 163(10): 5729 - 5734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Foster Allergic Networks Regulating Eosinophilia Am. J. Respir. Cell Mol. Biol., October 1, 1999; 21(4): 451 - 454. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
