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The Journal of Immunology, 1999, 162: 3957-3960.
Copyright © 1999 by The American Association of Immunologists

Increased Generation of CD8+ T Cell Clones in p53 Mutant Mice1

Xianzheng Zhou*, Stacey Wong*, Jurgen Walter*, Tyler Jacks*,{dagger} and Herman N. Eisen2,*

* Center for Cancer Research and Department of Biology, {dagger} Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139

Very few cultured CD8+ T cell clones can normally be obtained from a single mouse and maintained in long-term culture. To improve the yield, we immunized p53 mutant mice with peptides of Sendai virus (FAPGNYPAL) and influenza virus (ASNENMETM) origin. Substantially more clones could be derived from p53-/- mice than from similarly treated wild-type mice (p53+/+); an intermediate yield was obtained from heterozygous mice (p53+/-). CTL lines or clones from p53-/- mice exhibited greater proliferative activity and resistance to {gamma}-irradiation than those from p53+/+ mice, and were cytolytically potent.




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