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*
Centre Hospitalie Université de Montreal Research Centre, University of Montreal, Montreal, Quebec, Canada;
Fujisaki Institute, Hayashibara Biochemical Laboratories, Okayama, Japan; Department of Bioregulatory Function, University of Tokyo, School of Medicine, Tokyo, Japan; and
Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada
It is generally accepted that immunologically naive T cells display
a very restricted cytokine production profile consisting mainly of
IL-2, which is used as an autocrine growth factor. Here we report that
activated naive CD4+ T cells, of neonatal or adult origin,
express very high levels of soluble lymphotoxin (LT) 
(LT3), as
determined by ELISA, RNase protection assay, and intracytoplasmic
staining. Besides LT3 and IL-2, these cells also produce high levels
of TNF- together with significant amounts of IFN-
and IL-13.
Naive cells also express LTß mRNA and the membrane form of LT
(LTß). On average, naive CD4+ T cells secrete four
times more LT3 than Th1-like cells, twice more than naive
CD8+ T cells, and ten times more than B cells. Thus, naive
T cells express a large spectrum of cytokines, mainly of the Th1 type,
and the very high levels of LT3/TNF- that they release may play
an hitherto unsuspected role in the early stage of T cell-dependent
immune responses.
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