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The Journal of Immunology, 1999, 162: 3770-3774.
Copyright © 1999 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: SOCS-1 Is a Potent Inhibitor of IL-4 Signal Transduction1

J. A. Losman*, X. P. Chen{dagger}, D. Hilton§ and P. Rothman2,*,{dagger},{ddagger}

* Integrated Program in Molecular, Cellular, and Biophysical Studies, {dagger} Department of Medicine, and {ddagger} Department of Microbiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032; and § The Walter and Eliza Hall Institute for Medical Research and The Cooperative Research Center for Cellular Growth Factors, Parksville, Victoria, Australia

IL-4 is an important regulator of the activation, proliferation, and differentiation of many hematopoetic cells. Many of these biological effects result from the activation of Janus kinases (JAK)1 and JAK3 and the transcription factor Stat6. Recent data suggest that members of the SOCS (suppressor of cytokine signaling) family of proteins can inhibit JAK-STAT signaling. We have examined the ability of SOCS family members to suppress IL-4 signaling, and we have found that SOCS-1 potently inhibits the activation of JAK1 kinase and Stat6 in response to IL-4. Furthermore, SOCS-1 can inhibit the induction of CD23 expression by IL-4. SOCS-2 does not inhibit induction of signaling by IL-4, while inhibition of IL-4 signaling by SOCS-3 can be detected in transient transfection systems, but not in stable cell lines. These studies implicate SOCS-1 in modulation of IL-4 signaling and suggest that SOCS-1 may play a role in regulating the immune response.




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Home page
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J. Biol. Chem., August 2, 2002; 277(32): 28830 - 28835.
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Home page
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Home page
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Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
C. J. Greenhalgh and D. J. Hilton
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J. Leukoc. Biol., September 1, 2001; 70(3): 348 - 356.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
D. L. Krebs and D. J. Hilton
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Stem Cells, September 1, 2001; 19(5): 378 - 387.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
Y. Zhang, R. Apilado, J. Coleman, S. Ben-Sasson, S. Tsang, J. Hu-Li, W. E. Paul, and H. Huang
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[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., August 18, 2000; 275(34): 26500 - 26506.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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