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CUTTING EDGE |
Department of Immunology, Schering-Plough Research Institute, Kenilworth, NJ 07033
The CC chemokine known as 6Ckine (SLC, Exodus-2, or TCA4) has
been identified as a ligand for CCR7. Mouse 6Ckine has also
been shown to signal through mouse CXCR3 and share some of the
activities of IFN-
inducible protein 10 and monokine induced
by IFN-. Nonetheless, human 6Ckine has not been shown to bind
CXCR3 receptor or have angiostatic activity. In this study, we report
that human 6Ckine does not induce a calcium flux in either human CXCR3
or mouse CXCR3 transfected cells, although it is an equally potent
agonist as mouse 6Ckine and human macrophage inflammatory
protein-3ß in human CCR7 transfected cells. Mouse 6Ckine (but
not human 6Ckine) is capable of competing with radiolabeled IFN-
inducible protein 10 for human CXCR3. In addition, radiolabeled human
6Ckine does not bind to either human CXCR3 or mouse CXCR3. Together
these data suggest that human CC chemokine 6Ckine is not a ligand for
the human or mouse CXC chemokine receptor CXCR3.
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