| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
ß+ Cell Development: Evidence That Liver NK1.1+TCRß+ Cells Originate from Multiple Pathways1
*
Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, Toronto, Ontario, Canada;
Amgen Institute, Toronto, Ontario, Canada; and
Department of Immunology, Keio University School of Medicine, Tokyo, Japan
Using mice deficient for LFA-1, CD44, and ICAM-1, we
examined the role of these adhesion molecules in
NK1.1+TCR
ß+ (NKT) cell
development. Although no defect in NKT cell development was observed in
CD44-/- and ICAM-1-/- mice, a dramatic
reduction of liver NKT cells was observed in LFA-1-/-
mice. Normal numbers of NKT cells were present in other lymphoid organs
in LFA-1-/- mice. When LFA-1-/- splenocytes
were injected i.v. into wild-type mice, the frequency of NKT cells
among donor-derived cells in the recipient liver was normal. In
contrast, when LFA-1-/- bone marrow (BM) cells were
injected i.v. into irradiated wild-type mice, the frequency of liver
NKT cells was significantly lower than that of mice injected with
wild-type BM cells. Collectively, these data indicate that LFA-1 is
required for the development of liver NKT cells, rather than the
migration to and/or subsequent establishment of mature NKT cells in the
liver.
This article has been cited by other articles:
|
|
 |
|
  C. Wahl, P. Bochtler, R. Schirmbeck, and J. Reimann Type I IFN-Producing CD4 V{alpha}14i NKT Cells Facilitate Priming of IL-10-Producing CD8 T Cells by Hepatocytes J. Immunol., February 15, 2007; 178(4): 2083 - 2093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-i. Seino and M. Taniguchi Functionally distinct NKT cell subsets and subtypes J. Exp. Med., December 19, 2005; 202(12): 1623 - 1626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Matsumoto, E. Kubota, Y. Omi, U. Lee, and J. M. Penninger Essential Role of LFA-1 in Activating Th2-Like Responses by {alpha}-Galactosylceramide-Activated NKT Cells J. Immunol., October 15, 2004; 173(8): 4976 - 4984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Emoto, Y. Emoto, V. Brinkmann, M. Miyamoto, I. Yoshizawa, M. Staber, N. van Rooijen, A. Hamann, and S. H. E. Kaufmann Increased Resistance of LFA-1-Deficient Mice to Lipopolysaccharide-Induced Shock/Liver Injury in the Presence of TNF-{alpha} and IL-12 Is Mediated by IL-10: A Novel Role for LFA-1 in the Regulation of the Proinflammatory and Anti-Inflammatory Cytokine Balance J. Immunol., July 15, 2003; 171(2): 584 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Matsumoto, S. Tsunematsu, K.-i. Tsukinoki, Y. Ohmi, M. Iwamiya, A. Oliveira-dos-Santos, D. Tone, J. Shindo, and J. M. Penninger Essential Role of the Adhesion Receptor LFA-1 for T Cell-Dependent Fulminant Hepatitis J. Immunol., December 15, 2002; 169(12): 7087 - 7096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Trobonjaca, F. Leithauser, P. Moller, R. Schirmbeck, and J. Reimann Activating Immunity in the Liver. I. Liver Dendritic Cells (but Not Hepatocytes) Are Potent Activators of IFN-{gamma} Release by Liver NKT Cells J. Immunol., August 1, 2001; 167(3): 1413 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Apostolou, A. Cumano, G. Gachelin, and P. Kourilsky Evidence for Two Subgroups of CD4-CD8- NKT Cells with Distinct TCR{alpha}{beta} Repertoires and Differential Distribution in Lymphoid Tissues J. Immunol., September 1, 2000; 165(5): 2481 - 2490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miyamoto, M. Emoto, V. Brinkmann, N. van Rooijen, R. Schmits, E. Kita, and S. H. E. Kaufmann Cutting Edge: Contribution of NK Cells to the Homing of Thymic CD4+NKT Cells to the Liver J. Immunol., August 15, 2000; 165(4): 1729 - 1732. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
