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CUTTING EDGE |
,§
*
Department of Biochemistry, Hyogo College of Medicine, Hyogo, Japan;
Research Institute, International Medical Center of Japan, Tokyo, Japan;
Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan; and
§
Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Japan.
The human homologue of Drosophila Toll (hToll),
also called Toll-like receptor 4 (TLR4), is a recently cloned receptor
of the IL-1/Toll receptor family. Interestingly, the TLR4 gene has been
localized to the same region to which the Lps locus
(endotoxin unresponsive gene locus) is mapped. To examine the role of
TLR4 in LPS responsiveness, we have generated mice lacking TLR4.
Macrophages and B cells from TLR4-deficient mice did not respond to
LPS. All these manifestations were quite similar to those of
LPS-hyporesponsive C3H/HeJ mice. Furthermore, C3H/HeJ mice have, in the
cytoplasmic portion of TLR4, a single point mutation of the amino acid
that is highly conserved among the IL-1/Toll receptor family.
Overexpression of wild-type TLR4 but not the mutant TLR4 from C3H/HeJ
mice activated NF-
B. Taken together, the present study demonstrates
that TLR4 is the gene product that regulates LPS
response.
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P. Gong, D. J. Angelini, S. Yang, G. Xia, A. S. Cross, D. Mann, D. D. Bannerman, S. N. Vogel, and S. E. Goldblum TLR4 Signaling Is Coupled to SRC Family Kinase Activation, Tyrosine Phosphorylation of Zonula Adherens Proteins, and Opening of the Paracellular Pathway in Human Lung Microvascular Endothelia J. Biol. Chem., May 9, 2008; 283(19): 13437 - 13449. [Abstract] [Full Text] [PDF]
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T. Shimizu, Y. Kida, and K. Kuwano Ureaplasma parvum lipoproteins, including MB antigen, activate NF-{kappa}B through TLR1, TLR2 and TLR6 Microbiology, May 1, 2008; 154(5): 1318 - 1325. [Abstract] [Full Text] [PDF]
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B. Pang, D. Winn, R. Johnson, W. Hong, S. West-Barnette, N. Kock, and W. E. Swords Lipooligosaccharides Containing Phosphorylcholine Delay Pulmonary Clearance of Nontypeable Haemophilus influenzae Infect. Immun., May 1, 2008; 76(5): 2037 - 2043. [Abstract] [Full Text] [PDF]
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 D. L. Trott, E. M. Hellestad, M. Yang, and M. E. Cook Additions of Killed Whole Cell Bacteria Preparations to Freund Complete Adjuvant Alter Laying Hen Antibody Response to Soluble Protein Antigen Poult. Sci., May 1, 2008; 87(5): 912 - 917. [Abstract] [Full Text] [PDF]
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N. Zucchini, G. Bessou, S. Traub, S. H. Robbins, S. Uematsu, S. Akira, L. Alexopoulou, and M. Dalod Cutting Edge: Overlapping Functions of TLR7 and TLR9 for Innate Defense against a Herpesvirus Infection J. Immunol., May 1, 2008; 180(9): 5799 - 5803. [Abstract] [Full Text] [PDF]
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 B. Zhang, G. Ramesh, S. Uematsu, S. Akira, and W. B. Reeves TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity J. Am. Soc. Nephrol., May 1, 2008; 19(5): 923 - 932. [Abstract] [Full Text] [PDF]
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V. Jain, A. Halle, K. A. Halmen, E. Lien, M. Charrel-Dennis, S. Ram, D. T. Golenbock, and A. Visintin Phagocytosis and intracellular killing of MD-2 opsonized Gram-negative bacteria depend on TLR4 signaling Blood, May 1, 2008; 111(9): 4637 - 4645. [Abstract] [Full Text] [PDF]
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M. Leendertse, R. J. L. Willems, I. A. J. Giebelen, P. S. van den Pangaart, W. J. Wiersinga, A. F. de Vos, S. Florquin, M. J. M. Bonten, and T. van der Poll TLR2-Dependent MyD88 Signaling Contributes to Early Host Defense in Murine Enterococcus faecium Peritonitis J. Immunol., April 1, 2008; 180(7): 4865 - 4874. [Abstract] [Full Text] [PDF]
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Y. Ren, Y. Xie, G. Jiang, J. Fan, J. Yeung, W. Li, P. K. H. Tam, and J. Savill Apoptotic Cells Protect Mice against Lipopolysaccharide-Induced Shock J. Immunol., April 1, 2008; 180(7): 4978 - 4985. [Abstract] [Full Text] [PDF]
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M. C. Banas, B. Banas, K. L. Hudkins, T. A. Wietecha, M. Iyoda, E. Bock, P. Hauser, J. W. Pippin, S. J. Shankland, K. D. Smith, et al. TLR4 Links Podocytes with the Innate Immune System to Mediate Glomerular Injury J. Am. Soc. Nephrol., April 1, 2008; 19(4): 704 - 713. [Abstract] [Full Text] [PDF]
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 S. Lehnardt, E. Schott, T. Trimbuch, D. Laubisch, C. Krueger, G. Wulczyn, R. Nitsch, and J. R. Weber A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS J. Neurosci., March 5, 2008; 28(10): 2320 - 2331. [Abstract] [Full Text] [PDF]
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A. Koneti, M. J. Linke, E. Brummer, and D. A. Stevens Evasion of Innate Immune Responses: Evidence for Mannose Binding Lectin Inhibition of Tumor Necrosis Factor Alpha Production by Macrophages in Response to Blastomyces dermatitidis Infect. Immun., March 1, 2008; 76(3): 994 - 1002. [Abstract] [Full Text] [PDF]
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S. C. Gribar, R. J. Anand, C. P. Sodhi, and D. J. Hackam The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation J. Leukoc. Biol., March 1, 2008; 83(3): 493 - 498. [Abstract] [Full Text] [PDF]
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S. Knapp, S. von Aulock, M. Leendertse, I. Haslinger, C. Draing, D. T. Golenbock, and T. van der Poll Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor J. Immunol., March 1, 2008; 180(5): 3478 - 3484. [Abstract] [Full Text] [PDF]
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 T. Kawasaki, M. A. Choudhry, M. G. Schwacha, S. Fujimi, J. A. Lederer, K. I. Bland, and I. H. Chaudry Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process Am J Physiol Cell Physiol, March 1, 2008; 294(3): C754 - C764. [Abstract] [Full Text] [PDF]
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P. Tissieres, I. Dunn-Siegrist, M. Schappi, G. Elson, R. Comte, V. Nobre, and J. Pugin Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria Blood, February 15, 2008; 111(4): 2122 - 2131. [Abstract] [Full Text] [PDF]
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F. A. Amaral, D. Sachs, V. V. Costa, C. T. Fagundes, D. Cisalpino, T. M. Cunha, S. H. Ferreira, F. Q. Cunha, T. A. Silva, J. R. Nicoli, et al. Commensal microbiota is fundamental for the development of inflammatory pain PNAS, February 12, 2008; 105(6): 2193 - 2197. [Abstract] [Full Text] [PDF]
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S. M. Eswarappa, N. Basu, O. Joy, and D. Chakravortty Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages Innate Immunity, February 1, 2008; 14(1): 13 - 24. [Abstract] [PDF]
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T Watanabe, K Higuchi, A Kobata, H Nishio, T Tanigawa, M Shiba, K Tominaga, Y Fujiwara, N Oshitani, T Asahara, et al. Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent Gut, February 1, 2008; 57(2): 181 - 187. [Abstract] [Full Text] [PDF]
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 A. Miyake, Y. Murata, H. Okazawa, H. Ikeda, Y. Niwayama, H. Ohnishi, Y. Hirata, and T. Matozaki Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages. Genes Cells, February 1, 2008; 13(2): 209 - 219. [Abstract] [Full Text] [PDF]
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I. Vaknin, L. Blinder, L. Wang, R. Gazit, E. Shapira, O. Genina, M. Pines, E. Pikarsky, and M. Baniyash A common pathway mediated through Toll-like receptors leads to T- and natural killer-cell immunosuppression Blood, February 1, 2008; 111(3): 1437 - 1447. [Abstract] [Full Text] [PDF]
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E. Doz, N. Noulin, E. Boichot, I. Guenon, L. Fick, M. Le Bert, V. Lagente, B. Ryffel, B. Schnyder, V. F. J. Quesniaux, et al. Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent J. Immunol., January 15, 2008; 180(2): 1169 - 1178. [Abstract] [Full Text] [PDF]
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 A. Beck, R. Penner, and A. Fleig Lipopolysaccharide-induced down-regulation of Ca2+ release-activated Ca2+ currents (ICRAC) but not Ca2+-activated TRPM4-like currents (ICAN) in cultured mouse microglial cells J. Physiol., January 15, 2008; 586(2): 427 - 439. [Abstract] [Full Text] [PDF]
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H. S. Seo, S. M. Michalek, and M. H. Nahm Lipoteichoic Acid Is Important in Innate Immune Responses to Gram-Positive Bacteria Infect. Immun., January 1, 2008; 76(1): 206 - 213. [Abstract] [Full Text] [PDF]
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T. Shimizu, Y. Kida, and K. Kuwano Mycoplasma pneumoniae-Derived Lipopeptides Induce Acute Inflammatory Responses in the Lungs of Mice Infect. Immun., January 1, 2008; 76(1): 270 - 277. [Abstract] [Full Text] [PDF]
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M. Cabanski, M. Steinmuller, L. M. Marsh, E. Surdziel, W. Seeger, and J. Lohmeyer PKR Regulates TLR2/TLR4-Dependent Signaling in Murine Alveolar Macrophages Am. J. Respir. Cell Mol. Biol., January 1, 2008; 38(1): 26 - 31. [Abstract] [Full Text] [PDF]
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W. Stenzel, S. Soltek, M. Sanchez-Ruiz, S. Akira, H. Miletic, D. Schluter, and M. Deckert Both TLR2 and TLR4 Are Required for the Effective Immune Response in Staphylococcus aureus-Induced Experimental Murine Brain Abscess Am. J. Pathol., January 1, 2008; 172(1): 132 - 145. [Abstract] [Full Text] [PDF]
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Y. Asai, Y. Makimura, A. Kawabata, and T. Ogawa Soluble CD14 Discriminates Slight Structural Differences between Lipid As That Lead to Distinct Host Cell Activation J. Immunol., December 1, 2007; 179(11): 7674 - 7683. [Abstract] [Full Text] [PDF]
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