| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Up-Regulates the A2B Adenosine Receptor Expression in Macrophages: A Mechanism of Macrophage Deactivation1
*
Departament de Fisiologia (Group of Macrophage), Facultat de Biologia, and Fundació August Pi i Sunyer, Campus Bellvitge, Barcelona, Spain; and
Departament de Bioquímica i Biologia Molecular, Facultat de Química, Universitat de Barcelona, Barcelona, Spain
Adenosine is a potent endogenous anti-inflammatory agent
released by cells in metabolically unfavorable conditions, such as
hypoxia or ischemia. Adenosine modulates different functional
activities in macrophages. Some of these activities are believed to be
induced through the uptake of adenosine into the macrophages, while
others are due to the interaction with specific cell surface receptors.
In murine bone marrow-derived macrophages, the use of different
radioligands for adenosine receptors suggests the presence of
A2B and A3 adenosine receptor subtypes. The
presence of A2B receptors was confirmed by flow cytometry
using specific Abs. The A2B receptor is functional in
murine macrophages, as indicated by the fact that agonists of
A2B receptors, but not agonists for A1,
A2A, or A3, lead to an increase in cAMP levels.
IFN-
up-regulates the surface protein and gene expression of the
A2B adenosine receptor by induction of de novo synthesis.
The up-regulation of A2B receptors correlates with an
increase in cAMP production in macrophages treated with adenosine
receptor agonist. The stimulation of A2B receptors by
adenosine or its analogues inhibits the IFN--induced expression of
MHC class II genes and also the IFN--induced expression of nitric
oxide synthase and of proinflammatory cytokines. Therefore, the
up-regulation of the A2B adenosine receptor expression
induced by IFN- could be a feedback mechanism for macrophage
deactivation.
This article has been cited by other articles:
|
|
 |
|
  C. van der Putten, E. A. Zuiderwijk-Sick, L. van Straalen, E. D. de Geus, L. A. Boven, I. Kondova, A. P. IJzerman, and J. J. Bajramovic Differential Expression of Adenosine A3 Receptors Controls Adenosine A2A Receptor-Mediated Inhibition of TLR Responses in Microglia J. Immunol., June 15, 2009; 182(12): 7603 - 7612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sebastian, M. Serra, A. Yeramian, N. Serrat, J. Lloberas, and A. Celada Deacetylase Activity Is Required for STAT5-Dependent GM-CSF Functional Activity in Macrophages and Differentiation to Dendritic Cells J. Immunol., May 1, 2008; 180(9): 5898 - 5906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. L. Kolachala, R. Bajaj, M. Chalasani, and S. V. Sitaraman Purinergic receptors in gastrointestinal inflammation Am J Physiol Gastrointest Liver Physiol, February 1, 2008; 294(2): G401 - G410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. H. Nemeth, D. Bleich, B. Csoka, P. Pacher, J. G. Mabley, L. Himer, E. S. Vizi, E. A. Deitch, C. Szabo, B. N. Cronstein, et al. Adenosine receptor activation ameliorates type 1 diabetes FASEB J, August 1, 2007; 21(10): 2379 - 2388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mohsenin, M. D. Burdick, J. G. Molina, M. P. Keane, and M. R. Blackburn Enhanced CXCL1 production and angiogenesis in adenosine-mediated lung disease FASEB J, April 1, 2007; 21(4): 1026 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Hua, M. Kovarova, K. D. Chason, M. Nguyen, B. H. Koller, and S. L. Tilley Enhanced mast cell activation in mice deficient in the A2b adenosine receptor J. Exp. Med., January 22, 2007; 204(1): 117 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Morello, K. Ito, S. Yamamura, K.-Y. Lee, E. Jazrawi, P. DeSouza, P. Barnes, C. Cicala, and I. M. Adcock IL-1beta and TNF-{alpha} Regulation of the Adenosine Receptor (A2A) Expression: Differential Requirement for NF-{kappa}B Binding to the Proximal Promoter J. Immunol., November 15, 2006; 177(10): 7173 - 7183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Linden Ups and downs of adenosine Blood, September 1, 2006; 108(5): 1430 - 1430. [Full Text] [PDF]
|
|
|
|
|
|
E. Sanchez-Tillo, M. Comalada, C. Farrera, A. F. Valledor, J. Lloberas, and A. Celada Macrophage-Colony-Stimulating Factor-Induced Proliferation and Lipopolysaccharide-Dependent Activation of Macrophages Requires Raf-1 Phosphorylation to Induce Mitogen Kinase Phosphatase-1 Expression. J. Immunol., June 1, 2006; 176(11): 6594 - 6602. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fortin, D. Harbour, M. Fernandes, P. Borgeat, and S. Bourgoin Differential expression of adenosine receptors in human neutrophils: up-regulation by specific Th1 cytokines and lipopolysaccharide J. Leukoc. Biol., March 1, 2006; 79(3): 574 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Chunn, A. Mohsenin, H. W. J. Young, C. G. Lee, J. A. Elias, R. E. Kellems, and M. R. Blackburn Partially adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations Am J Physiol Lung Cell Mol Physiol, March 1, 2006; 290(3): L579 - L587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. H. Nemeth, C. S. Lutz, B. Csoka, E. A. Deitch, S. J. Leibovich, W. C. Gause, M. Tone, P. Pacher, E. S. Vizi, and G. Hasko Adenosine Augments IL-10 Production by Macrophages through an A2B Receptor-Mediated Posttranscriptional Mechanism J. Immunol., December 15, 2005; 175(12): 8260 - 8270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Lappas, J. M. Rieger, and J. Linden A2A Adenosine Receptor Induction Inhibits IFN-{gamma} Production in Murine CD4+ T Cells J. Immunol., January 15, 2005; 174(2): 1073 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. HAILU, T. VAN DER POLL, N. BERHE, and P. A. KAGER ELEVATED PLASMA LEVELS OF INTERFERON (IFN)-{gamma}, IFN-{gamma} INDUCING CYTOKINES, AND IFN-{gamma} INDUCIBLE CXC CHEMOKINES IN VISCERAL LEISHMANIASIS Am J Trop Med Hyg, November 1, 2004; 71(5): 561 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Marques, M. Brucet, J. Lloberas, and A. Celada STAT1 Regulates Lipopolysaccharide- and TNF-{alpha}-Dependent Expression of Transporter Associated with Antigen Processing 1 and Low Molecular Mass Polypeptide 2 Genes in Macrophages by Distinct Mechanisms J. Immunol., July 15, 2004; 173(2): 1103 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schnurr, T. Toy, A. Shin, G. Hartmann, S. Rothenfusser, J. Soellner, I. D. Davis, J. Cebon, and E. Maraskovsky Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells Blood, February 15, 2004; 103(4): 1391 - 1397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Headrick, B. Hack, and K. J. Ashton Acute adenosinergic cardioprotection in ischemic-reperfused hearts Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H1797 - H1818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. D. Khoa, M. C. Montesinos, A. J. Williams, M. Kelly, and B. N. Cronstein Th1 Cytokines Regulate Adenosine Receptors and Their Downstream Signaling Elements in Human Microvascular Endothelial Cells J. Immunol., October 15, 2003; 171(8): 3991 - 3998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. H. Neemeth, S. J. Leibovich, E. A. Deitch, E. S. Vizi, C. Szabo, and G. Hasko cDNA Microarray Analysis Reveals a Nuclear Factor-{kappa}B-Independent Regulation of Macrophage Function by Adenosine J. Pharmacol. Exp. Ther., September 1, 2003; 306(3): 1042 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Comalada, M. Cardo, J. Xaus, A. F. Valledor, J. Lloberas, F. Ventura, and A. Celada Decorin Reverses the Repressive Effect of Autocrine-Produced TGF-{beta} on Mouse Macrophage Activation J. Immunol., May 1, 2003; 170(9): 4450 - 4456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Rees, M. D. Lewis, B. M. Lewis, P. J. Smith, M. F. Scanlon, and J. Ham Adenosine-Regulated Cell Proliferation in Pituitary Folliculostellate and Endocrine Cells: Differential Roles for the A1 and A2B Adenosine Receptors Endocrinology, June 1, 2002; 143(6): 2427 - 2436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Leibovich, J.-F. Chen, G. Pinhal-Enfield, P. C. Belem, G. Elson, A. Rosania, M. Ramanathan, C. Montesinos, M. Jacobson, M. A. Schwarzschild, et al. Synergistic Up-Regulation of Vascular Endothelial Growth Factor Expression in Murine Macrophages by Adenosine A2A Receptor Agonists and Endotoxin Am. J. Pathol., June 1, 2002; 160(6): 2231 - 2244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. D. Khoa, M. C. Montesinos, A. B. Reiss, D. Delano, N. Awadallah, and B. N. Cronstein Inflammatory Cytokines Regulate Function and Expression of Adenosine A2A Receptors in Human Monocytic THP-1 Cells J. Immunol., October 1, 2001; 167(7): 4026 - 4032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M CUTOLO, A SULLI, C PIZZORNI, B SERIOLO, and R H STRAUB Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis Ann Rheum Dis, August 1, 2001; 60(8): 729 - 735. [Full Text] [PDF]
|
|
|
|
|
|
N. Boechat, F. Bouchonnet, M. Bonay, A. Grodet, V. Pelicic, B. Gicquel, and A. J. Hance Culture at High Density Improves the Ability of Human Macrophages to Control Mycobacterial Growth J. Immunol., May 15, 2001; 166(10): 6203 - 6211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Herrera, V. Casadó, F. Ciruela, P. Schofield, J. Mallol, C. Lluis, and R. Franco Adenosine A2B Receptors Behave as an Alternative Anchoring Protein for Cell Surface Adenosine Deaminase in Lymphocytes and Cultured Cells Mol. Pharmacol., January 1, 2001; 59(1): 127 - 134. [Abstract] [Full Text]
|
|
|
|
|
|
J. Xaus, M. Comalada, M. Barrachina, C. Herrero, E. Gonalons, C. Soler, J. Lloberas, and A. Celada The Expression of MHC Class II Genes in Macrophages Is Cell Cycle Dependent J. Immunol., December 1, 2000; 165(11): 6364 - 6371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. HASKÓ, D. G. KUHEL, J.-F. CHEN, M. A. SCHWARZSCHILD, E. A. DEITCH, J. G. MABLEY, A. MARTON, and C. SZABÓ Adenosine inhibits IL-12 and TNF-{alpha} production via adenosine A2a receptor-dependent and independent mechanisms FASEB J, October 1, 2000; 14(13): 2065 - 2074. [Abstract] [Full Text]
|
|
|
|
|
|
J. Xaus, A. F. Valledor, M. Cardo, L. Marques, J. Beleta, J. M. Palacios, and A. Celada Adenosine Inhibits Macrophage Colony-Stimulating Factor-Dependent Proliferation of Macrophages Through the Induction of p27kip-1 Expression J. Immunol., October 15, 1999; 163(8): 4140 - 4149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Soler, R. Valdes, J. Garcia-Manteiga, J. Xaus, M. Comalada, F. J. Casado, M. Modolell, B. Nicholson, C. MacLeod, A. Felipe, et al. Lipopolysaccharide-induced Apoptosis of Macrophages Determines the Up-regulation of Concentrative Nucleoside Transporters Cnt1 and Cnt2 through Tumor Necrosis Factor-alpha -dependent and -independent Mechanisms J. Biol. Chem., August 3, 2001; 276(32): 30043 - 30049. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
