| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129;
Meakins Christie Laboratories, Montreal Chest Institute Research Centre, McGill University, Montreal, Quebec, Canada; and
Department of Molecular Sciences, Pfizer Inc., Groton, CT 06340
Recruitment of activated T cells to mucosal surfaces, such as the
airway epithelium, is important in host defense and for the development
of inflammatory diseases at these sites. We therefore asked whether the
CXC chemokines IFN-induced protein of 10 kDa (IP-10), monokine induced
by IFN-
(Mig), and IFN-inducible T-cell 
-chemoattractant (I-TAC),
which specifically chemoattract activated T cells by signaling through
the chemokine receptor CXCR3, were inducible in respiratory epithelial
cells. The effects of proinflammatory cytokines, including IFN-
(Th1-type cytokine), Th2-type cytokines (IL-4, IL-10, and IL-13), and
dexamethasone were studied in normal human bronchial epithelial cells
(NHBEC) and in two human respiratory epithelial cell lines, A549 and
BEAS-2B. We found that IFN-, but not TNF- or IL-1ß, strongly
induced IP-10, Mig, and I-TAC mRNA accumulation mainly in NHBEC and
that TNF- and IL-1ß synergized with IFN- induction in all three
cell types. High levels of IP-10 protein (>800 ng/ml) were detected in
supernatants of IFN-/TNF--stimulated NHBEC. Neither dexamethasone
nor Th2 cytokines modulated IP-10, Mig, or I-TAC expression. Since
IFN- is up-regulated in tuberculosis (TB), using in situ
hybridization we studied the expression of IP-10 in the airways of TB
patients and found that IP-10 mRNA was expressed in the bronchial
epithelium. In addition, IP-10-positive cells obtained by
bronchoalveolar lavage were significantly increased in TB patients
compared with normal controls. These results show that activated
bronchial epithelium is an important source of IP-10, Mig, and I-TAC,
which may, in pulmonary diseases such as TB (in which IFN- is highly
expressed) play an important role in the recruitment of
activated T cells.
This article has been cited by other articles:
|
|
 |
|
  K. L. Wallace, M. A. Marshall, S. I. Ramos, J. A. Lannigan, J. J. Field, R. M. Strieter, and J. Linden NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-{gamma} and CXCR3 chemokines Blood, July 16, 2009; 114(3): 667 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Kelsen, M. O. Aksoy, M. Georgy, R. Hershman, R. Ji, X. Li, M. Hurford, C. Solomides, W. Chatila, and V. Kim Lymphoid Follicle Cells in Chronic Obstructive Pulmonary Disease Overexpress the Chemokine Receptor CXCR3 Am. J. Respir. Crit. Care Med., May 1, 2009; 179(9): 799 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Crawford, Y. Zhu, C. S. Green, M. D. Burdick, P. Sanz, F. Alem, A. D. O'Brien, B. Mehrad, R. M. Strieter, and M. A. Hughes Antimicrobial Effects of Interferon-Inducible CXC Chemokines against Bacillus anthracis Spores and Bacilli Infect. Immun., April 1, 2009; 77(4): 1664 - 1678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Nakagami, S. Favoreto Jr, G. Zhen, S.-W. Park, L. T. Nguyenvu, D. A. Kuperman, G. M. Dolganov, X. Huang, H. A. Boushey, P. C. Avila, et al. The Epithelial Anion Transporter Pendrin Is Induced by Allergy and Rhinovirus Infection, Regulates Airway Surface Liquid, and Increases Airway Reactivity and Inflammation in an Asthma Model J. Immunol., August 1, 2008; 181(3): 2203 - 2210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ji, C. M. Lee, L. W. Gonzales, Y. Yang, M. O. Aksoy, P. Wang, E. Brailoiu, N. Dun, M. T. Hurford, and S. G. Kelsen Human type II pneumocyte chemotactic responses to CXCR3 activation are mediated by splice variant A Am J Physiol Lung Cell Mol Physiol, June 1, 2008; 294(6): L1187 - L1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Porter, M. Falzon, and A. Hall Polarized Localization of Epithelial CXCL11 in Chronic Obstructive Pulmonary Disease and Mechanisms of T Cell Egression J. Immunol., February 1, 2008; 180(3): 1866 - 1877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Costa, R. Rufino, S. L. Traves, J. R. Lapa e Silva, P. J. Barnes, and L. E. Donnelly CXCR3 and CCR5 Chemokines in Induced Sputum From Patients With COPD Chest, January 1, 2008; 133(1): 26 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Tudhope, M. C. Catley, P. S. Fenwick, R. E. K. Russell, W. L. Rumsey, R. Newton, P. J. Barnes, and L. E. Donnelly The Role of I{kappa}B Kinase 2, but Not Activation of NF-{kappa}B, in the Release of CXCR3 Ligands from IFN-{gamma}-Stimulated Human Bronchial Epithelial Cells J. Immunol., November 1, 2007; 179(9): 6237 - 6245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Bayer, T. Muller, D. Myrtek, S. Sorichter, M. Ziegenhagen, J. Norgauer, G. Zissel, and M. Idzko Serotoninergic Receptors on Human Airway Epithelial Cells Am. J. Respir. Cell Mol. Biol., January 1, 2007; 36(1): 85 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. L. Fahy, S. L. Townley, and S. R. McColl CXCL16 Regulates Cell-Mediated Immunity to Salmonella enterica Serovar Enteritidis via Promotion of Gamma Interferon Production Infect. Immun., December 1, 2006; 74(12): 6885 - 6894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. V. Campanella, J. Grimm, L. A. Manice, R. A. Colvin, B. D. Medoff, G. R. Wojtkiewicz, R. Weissleder, and A. D. Luster Oligomerization of CXCL10 Is Necessary for Endothelial Cell Presentation and In Vivo Activity J. Immunol., November 15, 2006; 177(10): 6991 - 6998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kobayashi, T. Kondo, H. Takata, S. Yokota, and M. Takiguchi Functional and phenotypic analysis of human memory CD8+ T cells expressing CXCR3. J. Leukoc. Biol., August 1, 2006; 80(2): 320 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Woodman, A. Sutcliffe, D. Kaur, M. Berry, P. Bradding, I. D. Pavord, and C. E. Brightling Chemokine Concentrations and Mast Cell Chemotactic Activity in BAL Fluid in Patients With Eosinophilic Bronchitis and Asthma, and in Normal Control Subjects. Chest, August 1, 2006; 130(2): 371 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shahabuddin, R. Ji, P. Wang, E. Brailoiu, N. Dun, Y. Yang, M. O. Aksoy, and S. G. Kelsen CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways Am J Physiol Cell Physiol, July 1, 2006; 291(1): C34 - C39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. O. Aksoy, Y. Yang, R. Ji, P. J. Reddy, S. Shahabuddin, J. Litvin, T. J. Rogers, and S. G. Kelsen CXCR3 surface expression in human airway epithelial cells: cell cycle dependence and effect on cell proliferation Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L909 - L918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Han, K. Suzuki, H. Koike, K. Suzuki, H. Yoneyama, S. Narumi, F. Shimizu, and H. Kawachi IFN-Inducible Protein-10 Plays a Pivotal Role in Maintaining Slit-Diaphragm Function by Regulating Podocyte Cell-Cycle Balance J. Am. Soc. Nephrol., February 1, 2006; 17(2): 442 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Muller, H. Bayer, D. Myrtek, D. Ferrari, S. Sorichter, M. W. Ziegenhagen, G. Zissel, J. C. Virchow Jr., W. Luttmann, J. Norgauer, et al. The P2Y14 Receptor of Airway Epithelial Cells: Coupling to Intracellular Ca2+ and IL-8 Secretion Am. J. Respir. Cell Mol. Biol., December 1, 2005; 33(6): 601 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L.-S. Tang, P. K.-S. Chan, C.-K. Wong, K.-F. To, A. K.-L. Wu, Y.-M. Sung, D. S.-C. Hui, J. J.-Y. Sung, and C. W.-K. Lam Early Enhanced Expression of Interferon-Inducible Protein-10 (CXCL-10) and Other Chemokines Predicts Adverse Outcome in Severe Acute Respiratory Syndrome Clin. Chem., December 1, 2005; 51(12): 2333 - 2340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Curbishley, B. Eksteen, R. P. Gladue, P. Lalor, and D. H. Adams CXCR3 Activation Promotes Lymphocyte Transendothelial Migration across Human Hepatic Endothelium under Fluid Flow Am. J. Pathol., September 1, 2005; 167(3): 887 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Debbabi, S. Ghosh, A. B. Kamath, J. Alt, D. E. deMello, S. Dunsmore, and S. M. Behar Primary type II alveolar epithelial cells present microbial antigens to antigen-specific CD4+ T cells Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L274 - L279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Walrath, L. Zukowski, A. Krywiak, and R. F. Silver Resident Th1-Like Effector Memory Cells in Pulmonary Recall Responses to Mycobacterium tuberculosis Am. J. Respir. Cell Mol. Biol., July 1, 2005; 33(1): 48 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. L. Spurrell, S. Wiehler, R. S. Zaheer, S. P. Sanders, and D. Proud Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L85 - L95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Imaizumi, M. Kumagai, K. Taima, T. Fujita, H. Yoshida, and K. Satoh Involvement of retinoic acid-inducible gene-I in the IFN-{gamma}/STAT1 signalling pathway in BEAS-2B cells Eur. Respir. J., June 1, 2005; 25(6): 1077 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Johnson, S. E. Mertz, N. Gitiban, S. Hammond, R. LeGallo, R. K. Durbin, and J. E. Durbin Role for Innate IFNs in Determining Respiratory Syncytial Virus Immunopathology J. Immunol., June 1, 2005; 174(11): 7234 - 7241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Wysocki, A. Panoskaltsis-Mortari, B. R. Blazar, and J. S. Serody Leukocyte migration and graft-versus-host disease Blood, June 1, 2005; 105(11): 4191 - 4199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Brightling, D. Kaur, P. Berger, A. J. Morgan, A. J. Wardlaw, and P. Bradding Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration J. Leukoc. Biol., May 1, 2005; 77(5): 759 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jiang, J. Xu, C. Zhou, Z. Wu, S. Zhong, J. Liu, W. Luo, T. Chen, Q. Qin, and P. Deng Characterization of Cytokine/Chemokine Profiles of Severe Acute Respiratory Syndrome Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 850 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Waeckel, Z. Mallat, S. Potteaux, C. Combadiere, M. Clergue, M. Duriez, L. Bao, C. Gerard, B. J. Rollins, A. Tedgui, et al. Impairment in Postischemic Neovascularization in Mice Lacking the CXC Chemokine Receptor 3 Circ. Res., March 18, 2005; 96(5): 576 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kohrgruber, M. Groger, P. Meraner, E. Kriehuber, P. Petzelbauer, S. Brandt, G. Stingl, A. Rot, and D. Maurer Plasmacytoid Dendritic Cell Recruitment by Immobilized CXCR3 Ligands J. Immunol., December 1, 2004; 173(11): 6592 - 6602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Petkovic, C. Moghini, S. Paoletti, M. Uguccioni, and B. Gerber I-TAC/CXCL11 is a natural antagonist for CCR5 J. Leukoc. Biol., September 1, 2004; 76(3): 701 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Kelsen, M. O. Aksoy, Y. Yang, S. Shahabuddin, J. Litvin, F. Safadi, and T. J. Rogers The chemokine receptor CXCR3 and its splice variant are expressed in human airway epithelial cells Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L584 - L591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Hildebrandt, K. M. Olkiewicz, L. A. Corrion, Y. Chang, S. G. Clouthier, C. Liu, and K. R. Cooke Donor-derived TNF-{alpha} regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation Blood, July 15, 2004; 104(2): 586 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Zegarra-Moran, C. Folli, B. Manzari, R. Ravazzolo, L. Varesio, and L. J. V. Galietta Double Mechanism for Apical Tryptophan Depletion in Polarized Human Bronchial Epithelium J. Immunol., July 1, 2004; 173(1): 542 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Thomas, S. L. Kunkel, and N. W. Lukacs Regulation of Cockroach Antigen-Induced Allergic Airway Hyperreactivity by the CXCR3 Ligand CXCL9 J. Immunol., July 1, 2004; 173(1): 615 - 623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pilette, J.N. Francis, S.J. Till, and S.R. Durham CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge Eur. Respir. J., June 1, 2004; 23(6): 876 - 884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Raju, Y. Hoshino, K. Kuwabara, I. Belitskaya, S. Prabhakar, A. Canova, J. A. Gold, R. Condos, R. I. Pine, S. Brown, et al. Aerosolized Gamma Interferon (IFN-{gamma}) Induces Expression of the Genes Encoding the IFN-{gamma}-Inducible 10-Kilodalton Protein but Not Inducible Nitric Oxide Synthase in the Lung during Tuberculosis Infect. Immun., March 1, 2004; 72(3): 1275 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Han, H. Koike, T. Nakatsue, K. Suzuki, H. Yoneyama, S. Narumi, N. Kobayashi, P. Mundel, F. Shimizu, and H. Kawachi IFN-Inducible Protein-10 Has a Differential Role in Podocyte during Thy 1.1 Glomerulonephritis J. Am. Soc. Nephrol., December 1, 2003; 14(12): 3111 - 3126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Kayali, K. Van Gunst, I. L. Campbell, A. Stotland, M. Kritzik, G. Liu, M. Flodstrom-Tullberg, Y.-Q. Zhang, and N. Sarvetnick The stromal cell-derived factor-1{alpha}/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas J. Cell Biol., November 24, 2003; 163(4): 859 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Sundrud, S. M. Grill, D. Ni, K. Nagata, S. S. Alkan, A. Subramaniam, and D. Unutmaz Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation J. Immunol., October 1, 2003; 171(7): 3542 - 3549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nagaoka, A. Sakai, H. Nojima, Y. Suda, Y. Yokomizo, K. Imakawa, S. Sakai, and R. K. Christenson A Chemokine, Interferon (IFN)-{gamma}-Inducible Protein 10 kDa, Is Stimulated by IFN-{tau} and Recruits Immune Cells in the Ovine Endometrium Biol Reprod, April 1, 2003; 68(4): 1413 - 1421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Kallapur, A. H. Jobe, M. Ikegami, and C. J. Bachurski Increased IP-10 and MIG Expression after Intra-amniotic Endotoxin in Preterm Lamb Lung Am. J. Respir. Crit. Care Med., March 1, 2003; 167(5): 779 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Thomas, S. L. Kunkel, and N. W. Lukacs Differential Role of IFN-{gamma}-Inducible Protein 10 kDa in a Cockroach Antigen-Induced Model of Allergic Airway Hyperreactivity: Systemic Versus Local Effects J. Immunol., December 15, 2002; 169(12): 7045 - 7053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Hauser, G. F. Debes, S. Arce, G. Cassese, A. Hamann, A. Radbruch, and R. A. Manz Chemotactic Responsiveness Toward Ligands for CXCR3 and CXCR4 Is Regulated on Plasma Blasts During the Time Course of a Memory Immune Response J. Immunol., August 1, 2002; 169(3): 1277 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Mohan, Z. Ding, J. Hanly, and T. B. Issekutz IFN-{gamma}-Inducible T Cell {alpha} Chemoattractant Is a Potent Stimulator of Normal Human Blood T Lymphocyte Transendothelial Migration: Differential Regulation by IFN-{gamma} and TNF-{alpha} J. Immunol., June 15, 2002; 168(12): 6420 - 6428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Fahy, S. Senechal, J. Pene, A. Scherpereel, P. Lassalle, A.-B. Tonnel, H. Yssel, B. Wallaert, and A. Tsicopoulos Diesel Exposure Favors Th2 Cell Recruitment by Mononuclear Cells and Alveolar Macrophages from Allergic Patients by Differentially Regulating Macrophage-Derived Chemokine and IFN-{gamma}-Induced Protein-10 Production J. Immunol., June 1, 2002; 168(11): 5912 - 5919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Medoff, A. Sauty, A. M. Tager, J. A. Maclean, R. N. Smith, A. Mathew, J. H. Dufour, and A. D. Luster IFN-{gamma}-Inducible Protein 10 (CXCL10) Contributes to Airway Hyperreactivity and Airway Inflammation in a Mouse Model of Asthma J. Immunol., May 15, 2002; 168(10): 5278 - 5286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kai, K. Nasu, S. Nakamura, J. Fukuda, M. Nishida, and I. Miyakawa Expression of interferon-{gamma}-inducible protein-10 in human endometrial stromal cells Mol. Hum. Reprod., February 1, 2002; 8(2): 176 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Romagnani, E. Lazzeri, L. Lasagni, C. Mavilia, C. Beltrame, M. Francalanci, M. Rotondi, F. Annunziato, L. Maurenzig, L. Cosmi, et al. IP-10 and Mig Production by Glomerular Cells in Human Proliferative Glomerulonephritis and Regulation by Nitric Oxide J. Am. Soc. Nephrol., January 1, 2002; 13(1): 53 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, B. A. Luxon, A. Casola, R. P. Garofalo, M. Jamaluddin, and A. R. Brasier Expression of Respiratory Syncytial Virus-Induced Chemokine Gene Networks in Lower Airway Epithelial Cells Revealed by cDNA Microarrays J. Virol., October 1, 2001; 75(19): 9044 - 9058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. GarcIa-Lopez, D. Sancho, F. Sanchez-Madrid, and M. Marazuela Thyrocytes from Autoimmune Thyroid Disorders Produce the Chemokines IP-10 And Mig and Attract CXCR3+ Lymphocytes J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 5008 - 5016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Cole, T. Ganz, A. M. Liese, M. D. Burdick, L. Liu, and R. M. Strieter Cutting Edge: IFN-Inducible ELR- CXC Chemokines Display Defensin-Like Antimicrobial Activity J. Immunol., July 15, 2001; 167(2): 623 - 627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Dobrzanski, J. B. Reome, and R. W. Dutton Role of Effector Cell-Derived IL-4, IL-5, and Perforin in Early and Late Stages of Type 2 CD8 Effector Cell-Mediated Tumor Rejection J. Immunol., July 1, 2001; 167(1): 424 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.M. Verleden, R.M. du Bois, D. Bouros, M. Drent, A. Millar, J. Muller-Quernheim, G. Semenzato, S. Johnson, G. Sourvinos, D. Olivieri, et al. Genetic predisposition and pathogenetic mechanisms of interstitial lung diseases of unknown origin Eur. Respir. J., July 1, 2001; 18(32_suppl): 17S - 29s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Loetscher and I. Clark-Lewis Agonistic and antagonistic activities of chemokines J. Leukoc. Biol., June 1, 2001; 69(6): 881 - 884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Agostini, F. Calabrese, F. Rea, M. Facco, A. Tosoni, M. Loy, G. Binotto, M. Valente, L. Trentin, and G. Semenzato CXCR3 and Its Ligand CXCL10 Are Expressed by Inflammatory Cells Infiltrating Lung Allografts and Mediate Chemotaxis of T Cells at Sites of Rejection Am. J. Pathol., May 1, 2001; 158(5): 1703 - 1711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cecilia Berin, L. Eckmann, D. H. Broide, and M. F. Kagnoff Regulated Production of the T Helper 2-Type T-Cell Chemoattractant TARC by Human Bronchial Epithelial Cells In Vitro and in Human Lung Xenografts Am. J. Respir. Cell Mol. Biol., April 1, 2001; 24(4): 382 - 389. [Abstract] [Full Text]
|
|
|
|
|
|
B. Qiu, K. A. Frait, F. Reich, E. Komuniecki, and S. W. Chensue Chemokine Expression Dynamics in Mycobacterial (Type-1) and Schistosomal (Type-2) Antigen-Elicited Pulmonary Granuloma Formation Am. J. Pathol., April 1, 2001; 158(4): 1503 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Wiley, K. Palmer, B. U. Gajewska, M. R. Stampfli, D. Alvarez, A. J. Coyle, J.-C. Gutierrez-Ramos, and M. Jordana Expression of the Th1 Chemokine IFN-{{gamma}}-Inducible Protein 10 in the Airway Alters Mucosal Allergic Sensitization in Mice J. Immunol., February 15, 2001; 166(4): 2750 - 2759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Campbell, C. E. Brightling, F. A. Symon, S. Qin, K. E. Murphy, M. Hodge, D. P. Andrew, L. Wu, E. C. Butcher, and A. J. Wardlaw Expression of Chemokine Receptors by Lung T Cells from Normal and Asthmatic Subjects J. Immunol., February 15, 2001; 166(4): 2842 - 2848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. AGOSTINI, M. FACCO, M. SIVIERO, D. CAROLLO, S. GALVAN, A. M. CATTELAN, R. ZAMBELLO, L. TRENTIN, and G. SEMENZATO CXC Chemokines IP-10 and Mig Expression and Direct Migration of Pulmonary CD8+/CXCR3+ T Cells in the Lungs of Patients with HIV Infection and T-Cell Alveolitis Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): 1466 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Dixon, J. B. Mandac, D. K. Madtes, P. J. Martin, and J. G. Clark Chemokine expression in Th1 cell-induced lung injury: prominence of IFN-gamma -inducible chemokines Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L592 - L599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Liu, B. P. Chen, P. Oertel, M. J. Buchmeier, D. Armstrong, T. A. Hamilton, and T. E. Lane Cutting Edge: The T Cell Chemoattractant IFN-Inducible Protein 10 Is Essential in Host Defense Against Viral-Induced Neurologic Disease J. Immunol., September 1, 2000; 165(5): 2327 - 2330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Albanesi, C. Scarponi, S. Sebastiani, A. Cavani, M. Federici, O. De Pita, P. Puddu, and G. Girolomoni IL-4 Enhances Keratinocyte Expression of CXCR3 Agonistic Chemokines J. Immunol., August 1, 2000; 165(3): 1395 - 1402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. N. Lauw, A. J. H. Simpson, J. M. Prins, S. J. H. van Deventer, W. Chaowagul, N. J. White, and T. van der Poll The CXC Chemokines Gamma Interferon (IFN-gamma )-Inducible Protein 10 and Monokine Induced by IFN-gamma Are Released during Severe Melioidosis Infect. Immun., July 1, 2000; 68(7): 3888 - 3893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Widney, Y.-R. Xia, A. J. Lusis, and J. B. Smith The Murine Chemokine CXCL11 (IFN-Inducible T Cell {alpha} Chemoattractant) Is an IFN-{gamma}- and Lipopolysaccharide- Inducible Glucocorticoid-Attenuated Response Gene Expressed in Lung and Other Tissues During Endotoxemia J. Immunol., June 15, 2000; 164(12): 6322 - 6331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Marx, F. Mach, A. Sauty, J. H. Leung, M. N. Sarafi, R. M. Ransohoff, P. Libby, J. Plutzky, and A. D. Luster Peroxisome Proliferator-Activated Receptor-{gamma} Activators Inhibit IFN-{gamma}-Induced Expression of the T Cell-Active CXC Chemokines IP-10, Mig, and I-TAC in Human Endothelial Cells J. Immunol., June 15, 2000; 164(12): 6503 - 6508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kinoshita, G. Tesch, A. Schwarting, R. Maron, A. H. Sharpe, and V. R. Kelley Costimulation by B7-1 and B7-2 Is Required for Autoimmune Disease in MRL-Faslpr Mice J. Immunol., June 1, 2000; 164(11): 6046 - 6056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Mazanet, K. Neote, and C. C. W. Hughes Expression of IFN-Inducible T Cell {alpha} Chemoattractant by Human Endothelial Cells Is Cyclosporin A-Resistant and Promotes T Cell Adhesion: Implications for Cyclosporin A-Resistant Immune Inflammation J. Immunol., May 15, 2000; 164(10): 5383 - 5388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jones, R. J. Benjamin, A. Shahsafaei, and D. M. Dorfman The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia Blood, January 15, 2000; 95(2): 627 - 632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Lee and J. J. Lee The Macroimportance of the Pulmonary Immune Microenvironment Am. J. Respir. Cell Mol. Biol., September 1, 1999; 21(3): 298 - 302. [Full Text]
|
|
|
|
 |
|
 P. Loetscher, A. Pellegrino, J.-H. Gong, I. Mattioli, M. Loetscher, G. Bardi, M. Baggiolini, and I. Clark-Lewis The Ligands of CXC Chemokine Receptor 3, I-TAC, Mig, and IP10, Are Natural Antagonists for CCR3 J. Biol. Chem., January 26, 2001; 276(5): 2986 - 2991. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
