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The Journal of Immunology, 1999, 162: 3428-3436.
Copyright © 1999 by The American Association of Immunologists

Toward a Role of Dendritic Cells in the Germinal Center Reaction: Triggering of B Cell Proliferation and Isotype Switching1

Bertrand Dubois2,*, Clarisse Barthélémy2,*, Isabelle Durand*, Yong-Jun Liu{dagger}, Christophe Caux* and Francine Brière3,*

* Schering Plough, Laboratory for Immunological Research, Dardilly, France; and {dagger} DNAX Research Institute, Palo Alto, CA 94304

We have reported previously that in vitro generated dendritic cells (DC) can directly regulate B cell responses. Recently, germinal center DC (GCDC) were identified within B cell follicles. Due to their particular localization, we have tested in the present study whether GCDC could contribute to key events characteristic of the GC reaction. Our present results demonstrate that 1) ex vivo GCDC induce a dramatic GC B cell expansion upon CD40 and IL-2 activation and drive plasma cell differentiation, 2) this property is shared by GCDC and blood DC, but not by Langerhans cells, 3) IL-12 production by GCDC is critical in GC B cell expansion and differentiation, and 4) importantly, GCDC also induce IL-10-independent isotype switching toward IgG1. These observations support the novel concept that GCDC directly contribute to the germinal center reaction.




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