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Reciprocal Expression in CD4 or CD8 Subsets of Different Members of the V11 Gene Family Correlates with Sequence Polymorphism¹

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037

Previous staining studies with TCR V11-specific mAbs showed that V11.1/11.2 (AV11S1 and S2) expression was selectively favored in the CD4⁺ peripheral T cell population. As this phenomenon was essentially independent of the MHC haplotype, it was suggested that AV11S1 and S2 TCRs exert a preference for recognition of class II MHC molecules. The V segment of the TCR -chain is suggested to have a primary role in shaping the T cell repertoire due to selection for class I or II molecules acting through the complementarity determining regions (CDR) 1 and CDR2 residues. We have analyzed the repertoire of V11 family members expressed in C57BL/6 mice and have identified a new member of this family; AV11S8. We show that, whereas AV11S1 and S2 are more frequent in CD4⁺ cells, AV11S3 and S8 are more frequent in CD8⁺ cells. The sequences in the CDR1 and CDR2 correlate with differential expression in CD4⁺ or CD8⁺ cells, a phenomenon that is also observed in BALB/c mice. With no apparent restriction in TCR J usage or CDR3 length in C57BL/6, these findings support the idea of V-dependent T cell repertoire selection through preferential recognition of MHC class I or class II molecules.

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