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T Cells Contribute to Control of Chronic Parasitemia in Plasmodium chabaudi Infections in Mice1
Department of Biology, Imperial College of Science, Technology and Medicine, London, U.K.
During a primary infection of mice with Plasmodium
chabaudi, 
T cells are stimulated and their expansion
coincides with recovery from the acute phase of infection in normal
mice or with chronic infections in B cell-deficient mice (µ-MT). To
determine whether the large T cell pool observed in female B
cell-deficient mice is responsible for controlling the chronic
infection, studies were done using double-knockout mice deficient in
both B and cells (µ-MT x -/-TCR) and in
T cell-depleted µ-MT mice. In both types of T
cell-deficient mice, the early parasitemia following the peak of
infection was exacerbated, and the chronic parasitemia was maintained
at significantly higher levels in the absence of T cells. The
majority of T cells in C57BL/6 and µ-MT mice responding to
infection belonged predominantly to a single family of T cells
with TCR composed of V2V4 chains and which produced IFN-
rather than IL-4.
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