| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
Infection with Chlamydia pneumoniae is a common
cause of acute respiratory disease in man and is also associated with
atherosclerotic cardiovascular disorder. Herein, we have compared
bacterial load and immune parameters of C.
pneumoniae-infected mice genomically lacking T cell
coreceptors, cytokine receptors, or cytotoxic effector molecules. A
protective role for CD8+ cells is shown by the enhanced
severity of infection of CD8-/- or
TAP-1-/-/ß2-microglobulin -/-
mice. CD8+ cells hindered a parasite growth-promoting role
of CD4+ T cells, as indicated by the higher sensitivity to
early infection of CD8-/- than
CD4-/-/CD8-/- mice, which was further
confirmed in experiments in which SCID mice were reconstituted with
either CD4+ or CD4+ plus CD8+ T
cells. Interestingly, CD4+ T cells played a dual role,
detrimental early (14 and 24 days) after infection but protective at
later time points (60 days after infection). The CD8+ T
cell protection was perforin independent. The early deleterious role of
CD4+ in the absence of CD8+ T cells was
associated with enhanced IL-4 and IL-10 mRNA levels and delayed IFN-
mRNA accumulation in lungs. In line with this,
IFN-R-/- (but not TNFRp55 -/-) mice
showed dramatically increased susceptibility to C.
pneumoniae, linked to reduced inducible nitric oxide synthase
(iNOS) mRNA accumulation, but not to diminished levels of specific Abs.
The increased susceptibility of iNOS-/- mice indicates a
protective role for iNOS activity during infection with C.
pneumoniae. The higher sensitivity of IFN-R-/-
mice to C. pneumoniae compared with that of SCID or
recombination-activating gene-1-/- mice suggested a
relevant protective role of IFN--dependent innate mechanisms of
protection.
This article has been cited by other articles:
|
|
 |
|
  A. Mosa, C. Trumstedt, E. Eriksson, O. Soehnlein, F. Heuts, K. Janik, A. Klos, O. Dittrich-Breiholz, M. Kracht, A. Hidmark, et al. Nonhematopoietic Cells Control the Outcome of Infection with Listeria monocytogenes in a Nucleotide Oligomerization Domain 1-Dependent Manner Infect. Immun., July 1, 2009; 77(7): 2908 - 2918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Walch, S. K. Rampini, I. Stoeckli, S. Latinovic-Golic, C. Dumrese, H. Sundstrom, A. Vogetseder, J. Marino, D. L. Glauser, M. van den Broek, et al. Involvement of CD252 (CD134L) and IL-2 in the Expression of Cytotoxic Proteins in Bacterial- or Viral-Activated Human T Cells J. Immunol., June 15, 2009; 182(12): 7569 - 7579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Rodriguez, R. Lang, N. Wantia, C. Cirl, T. Ertl, S. Durr, H. Wagner, and T. Miethke Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK J. Leukoc. Biol., December 1, 2008; 84(6): 1585 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Schmeck, W. Beermann, P. D. N'Guessan, A. C. Hocke, B. Opitz, J. Eitel, Q. T. Dinh, M. Witzenrath, M. Krull, N. Suttorp, et al. Simvastatin Reduces Chlamydophila pneumoniae-Mediated Histone Modifications and Gene Expression in Cultured Human Endothelial Cells Circ. Res., April 25, 2008; 102(8): 888 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yang, P. Stark, K. Janik, H. Wigzell, and M. E. Rottenberg SOCS-1 Protects against Chlamydia pneumoniae-Induced Lethal Inflammation but Hampers Effective Bacterial Clearance J. Immunol., March 15, 2008; 180(6): 4040 - 4049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Kaiko, S. Phipps, D. K. Hickey, C. E. Lam, P. M. Hansbro, P. S. Foster, and K. W. Beagley Chlamydia muridarum Infection Subverts Dendritic Cell Function to Promote Th2 Immunity and Airways Hyperreactivity J. Immunol., February 15, 2008; 180(4): 2225 - 2232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tvinnereim and B. Wizel CD8+ T Cell Protective Immunity against Chlamydia pneumoniae Includes an H2-M3-Restricted Response That Is Largely CD4+ T Cell-Independent J. Immunol., September 15, 2007; 179(6): 3947 - 3957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hermann Review: Variability of host pathogen interaction Innate Immunity, August 1, 2007; 13(4): 199 - 218. [Abstract] [PDF]
|
|
|
|
|
|
A. G. Joyee, H. Qiu, S. Wang, Y. Fan, L. Bilenki, and X. Yang Distinct NKT Cell Subsets Are Induced by Different Chlamydia Species Leading to Differential Adaptive Immunity and Host Resistance to the Infections J. Immunol., January 15, 2007; 178(2): 1048 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sakai, H. Suzuki, H. Oda, T. Akaike, Y. Azuma, T. Murakami, K. Sugi, T. Ito, H. Ichinose, S. Koyasu, et al. Phosphoinositide 3-Kinase in Nitric Oxide Synthesis in Macrophage: CRITICAL DIMERIZATION OF INDUCIBLE NITRIC-OXIDE SYNTHASE J. Biol. Chem., June 30, 2006; 281(26): 17736 - 17742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Rothfuchs, C. Trumstedt, F. Mattei, G. Schiavoni, A. Hidmark, H. Wigzell, and M. E. Rottenberg STAT1 Regulates IFN-{alpha}beta- and IFN-{gamma}-Dependent Control of Infection with Chlamydia pneumoniae by Nonhemopoietic Cells. J. Immunol., June 1, 2006; 176(11): 6982 - 6990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tormakangas, L. Erkkila, T. Korhonen, T. Tiirola, A. Bloigu, P. Saikku, and M. Leinonen Effects of Repeated Chlamydia pneumoniae Inoculations on Aortic Lipid Accumulation and Inflammatory Response in C57BL/6J Mice Infect. Immun., October 1, 2005; 73(10): 6458 - 6466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Naiki, K. S. Michelsen, N. W. J. Schroder, R. Alsabeh, A. Slepenkin, W. Zhang, S. Chen, B. Wei, Y. Bulut, M. H. Wong, et al. MyD88 Is Pivotal for the Early Inflammatory Response and Subsequent Bacterial Clearance and Survival in a Mouse Model of Chlamydia pneumoniae Pneumonia J. Biol. Chem., August 12, 2005; 280(32): 29242 - 29249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Pinchuk, B. C. Starcher, B. Livingston, A. Tvninnereim, S. Wu, E. Appella, J. Sidney, A. Sette, and B. Wizel A CD8+ T Cell Heptaepitope Minigene Vaccine Induces Protective Immunity against Chlamydia pneumoniae J. Immunol., May 1, 2005; 174(9): 5729 - 5739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Little, A. Bowe, R. Lin, J. Litsky, R. M. Fogel, B. J. Balin, and K. L. Fresa-Dillon Age Alterations in Extent and Severity of Experimental Intranasal Infection with Chlamydophila pneumoniae in BALB/c Mice Infect. Immun., March 1, 2005; 73(3): 1723 - 1734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. de Kruif, E. C.M. van Gorp, T. T. Keller, J. M. Ossewaarde, and H. ten Cate Chlamydia pneumoniae infections in mouse models: relevance for atherosclerosis research Cardiovasc Res, February 1, 2005; 65(2): 317 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Gervassi, K. H. Grabstein, P. Probst, B. Hess, M. R. Alderson, and S. P. Fling Human CD8+ T Cells Recognize the 60-kDa Cysteine-Rich Outer Membrane Protein from Chlamydia trachomatis J. Immunol., December 1, 2004; 173(11): 6905 - 6913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Gold, R. M. Simmons, T. W. Petersen, L. A. Campbell, C.-C. Kuo, and A. Aderem Amphiphysin IIm Is Required for Survival of Chlamydia pneumoniae in Macrophages J. Exp. Med., September 7, 2004; 200(5): 581 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Rothfuchs, M. R. Kreuger, H. Wigzell, and M. E. Rottenberg Macrophages, CD4+ or CD8+ Cells Are Each Sufficient for Protection against Chlamydia pneumoniae Infection through their Ability to Secrete IFN-{gamma} J. Immunol., February 15, 2004; 172(4): 2407 - 2415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Fischer, T. Harlander, J. Vier, and G. Hacker Protection against CD95-Induced Apoptosis by Chlamydial Infection at a Mitochondrial Step Infect. Immun., February 1, 2004; 72(2): 1107 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B Chesebro, E. Blessing, C.-C. Kuo, M. E Rosenfeld, M. Puolakkainen, and L. A. Campbell Nitric oxide synthase plays a role in Chlamydia pneumoniae-induced atherosclerosis Cardiovasc Res, October 15, 2003; 60(1): 170 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xu, R. Lucas, M. Schuchmann, S. Kuhnle, T. Meergans, A. P. Barreiros, A. W. Lohse, G. Otto, and A. Wendel GM-CSF Restores Innate, But Not Adaptive, Immune Responses in Glucocorticoid-Immunosuppressed Human Blood In Vitro J. Immunol., July 15, 2003; 171(2): 938 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Airaksinen, T. Penttila, E. Wahlstrom, J. M. Vuola, M. Puolakkainen, and M. Sarvas Production of Chlamydia pneumoniae Proteins in Bacillus subtilis and Their Use in Characterizing Immune Responses in the Experimental Infection Model Clin. Vaccine Immunol., May 1, 2003; 10(3): 367 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. San Mateo, M. M. Chua, S. R. Weiss, and H. Shen Perforin-Mediated CTL Cytolysis Counteracts Direct Cell-Cell Spread of Listeria monocytogenes J. Immunol., November 1, 2002; 169(9): 5202 - 5208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Wizel, B. C. Starcher, B. Samten, Z. Chroneos, P. F. Barnes, J. Dzuris, Y. Higashimoto, E. Appella, and A. Sette Multiple Chlamydiapneumoniae Antigens Prime CD8+ Tc1 Responses That Inhibit Intracellular Growth of This Vacuolar Pathogen J. Immunol., September 1, 2002; 169(5): 2524 - 2535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Saren, S. Pascolo, S. Stevanovic, T. Dumrese, M. Puolakkainen, M. Sarvas, H.-G. Rammensee, and J. M. Vuola Identification of Chlamydia pneumoniae-Derived Mouse CD8 Epitopes Infect. Immun., July 1, 2002; 70(7): 3336 - 3343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Huang, F. J. DeGraves, S. D. Lenz, D. Gao, P. Feng, D. Li, T. Schlapp, and B. Kaltenboeck The quantity of nitric oxide released by macrophages regulates Chlamydia-induced disease PNAS, March 19, 2002; 99(6): 3914 - 3919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.C. von Hertzen Role of persistent infection in the control and severity of asthma: focus on Chlamydia pneumoniae Eur. Respir. J., March 1, 2002; 19(3): 546 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gigliotti Rothfuchs, D. Gigliotti, K. Palmblad, U. Andersson, H. Wigzell, and M. E. Rottenberg IFN-{alpha}{beta}-Dependent, IFN-{gamma} Secretion by Bone Marrow-Derived Macrophages Controls an Intracellular Bacterial Infection J. Immunol., December 1, 2001; 167(11): 6453 - 6461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Prebeck, C. Kirschning, S. Durr, C. da Costa, B. Donath, K. Brand, V. Redecke, H. Wagner, and T. Miethke Predominant Role of Toll-Like Receptor 2 Versus 4 in Chlamydia pneumoniae-Induced Activation of Dendritic Cells J. Immunol., September 15, 2001; 167(6): 3316 - 3323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Caligiuri, M. Rottenberg, A. Nicoletti, H. Wigzell, and G. K. Hansson Chlamydia pneumoniae Infection Does Not Induce or Modify Atherosclerosis in Mice Circulation, June 12, 2001; 103(23): 2834 - 2838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Coutinho-Silva, J.-L. Perfettini, P. M. Persechini, A. Dautry-Varsat, and D. M. Ojcius Modulation of P2Z/P2X7 receptor activity in macrophages infected with Chlamydia psittaci Am J Physiol Cell Physiol, January 1, 2001; 280(1): C81 - C89. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Halme, J. Latvala, R. Karttunen, I. Palatsi, P. Saikku, and H.-M. Surcel Cell-Mediated Immune Response during Primary Chlamydia pneumoniae Infection Infect. Immun., December 1, 2000; 68(12): 7156 - 7158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Agerberth, J. Charo, J. Werr, B. Olsson, F. Idali, L. Lindbom, R. Kiessling, H. Jornvall, H. Wigzell, and G. H. Gudmundsson The human antimicrobial and chemotactic peptides LL-37 and alpha -defensins are expressed by specific lymphocyte and monocyte populations Blood, November 1, 2000; 96(9): 3086 - 3093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Liuba, P. Karnani, E. Pesonen, I. Paakkari, A. Forslid, L. Johansson, K. Persson, T. Wadstrom, and R. Laurini Endothelial Dysfunction After Repeated Chlamydia pneumoniae Infection in Apolipoprotein E-Knockout Mice Circulation, August 29, 2000; 102(9): 1039 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Rottenberg, A. Gigliotti Rothfuchs, D. Gigliotti, M. Ceausu, C. Une, V. Levitsky, and H. Wigzell Regulation and Role of IFN-{gamma} in the Innate Resistance to Infection with Chlamydia pneumoniae J. Immunol., May 1, 2000; 164(9): 4812 - 4818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Vuola, V. Puurula, M. Anttila, P. H. Makela, and N. Rautonen Acquired Immunity to Chlamydia pneumoniae Is Dependent on Gamma Interferon in Two Mouse Strains That Initially Differ in This Respect after Primary Challenge Infect. Immun., February 1, 2000; 68(2): 960 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. SINGH, S J. WORT, and T. W EVANS Inducible nitric oxide and pulmonary infection Thorax, November 1, 1999; 54(11): 959 - 960. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
