| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Immunology Program, Cornell University Graduate School of Medical Sciences, and Department of Medicine, Division of Immunology, Cornell University Medical College, New York, NY 10021;
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Rockville MD 20852; and
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, MD 20892
The newly recognized regulators of G protein signaling (RGS)
attenuate heterotrimeric G protein signaling pathways. We have cloned
an IL-2-induced gene from human T cells, cytokine-responsive gene 1,
which encodes a member of the RGS family, RGS16. The RGS16 protein
binds Gi
and Gq proteins present in T
cells, and inhibits Gi- and Gq-mediated
signaling pathways. By comparison, the mitogen-induced RGS2 inhibits
Gq but not Gi signaling. Moreover, the two RGS
genes exhibit marked differences in expression patterns. The
IL-2-induced expression of the RGS16 gene in T cells is suppressed by
elevated cAMP, whereas the RGS2 gene shows a reciprocal pattern of
regulation by these stimuli. Because the mitogen and cytokine receptors
that trigger expression of RGS2 and RGS16 in T cells do not activate
heterotrimeric G proteins, these RGS proteins and the G proteins that
they regulate may play a heretofore unrecognized role in T cell
functional responses to Ag and cytokine
activation.
This article has been cited by other articles:
|
|
 |
|
  Z. Xie, M. C. Gong, W. Su, J. Turk, and Z. Guo Group VIA Phospholipase A2 (iPLA2beta) Participates in Angiotensin II-induced Transcriptional Up-regulation of Regulator of G-protein Signaling-2 in Vascular Smooth Muscle Cells J. Biol. Chem., August 31, 2007; 282(35): 25278 - 25289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Timmusk, C. Fossum, and M. Berg Porcine circovirus type 2 replicase binds the capsid protein and an intermediate filament-like protein. J. Gen. Virol., November 1, 2006; 87(Pt 11): 3215 - 3223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Romero, M. W. Plonczynski, E. P. Gomez-Sanchez, L. L. Yanes, and C. E. Gomez-Sanchez RGS2 Is Regulated by Angiotensin II and Functions as a Negative Feedback of Aldosterone Production in H295R Human Adrenocortical Cells Endocrinology, August 1, 2006; 147(8): 3889 - 3897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Berthebaud, C. Riviere, P. Jarrier, A. Foudi, Y. Zhang, D. Compagno, A. Galy, W. Vainchenker, and F. Louache RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes Blood, November 1, 2005; 106(9): 2962 - 2968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Schwable, C. Choudhary, C. Thiede, L. Tickenbrock, B. Sargin, C. Steur, M. Rehage, A. Rudat, C. Brandts, W. E. Berdel, et al. RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation Blood, March 1, 2005; 105(5): 2107 - 2114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Estes, T. C. Thacker, D. L. Hampton, S. A. Kell, B. F. Keele, E. A. Palenske, K. M. Druey, and G. F. Burton Follicular Dendritic Cell Regulation of CXCR4-Mediated Germinal Center CD4 T Cell Migration J. Immunol., November 15, 2004; 173(10): 6169 - 6178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Moratz, J. R. Hayman, H. Gu, and J. H. Kehrl Abnormal B-Cell Responses to Chemokines, Disturbed Plasma Cell Localization, and Distorted Immune Tissue Architecture in Rgs1-/- Mice Mol. Cell. Biol., July 1, 2004; 24(13): 5767 - 5775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lippert, D. L. Yowe, J.-A. Gonzalo, J. P. Justice, J. M. Webster, E. R. Fedyk, M. Hodge, C. Miller, J.-C. Gutierrez-Ramos, F. Borrego, et al. Role of Regulator of G Protein Signaling 16 in Inflammation- Induced T Lymphocyte Migration and Activation J. Immunol., August 1, 2003; 171(3): 1542 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, P. E. Massa, A. Hanidu, G. W. Peet, P. Aro, A. Savitt, S. Mische, J. Li, and K. B. Marcu IKKalpha , IKKbeta , and NEMO/IKKgamma Are Each Required for the NF-kappa B-mediated Inflammatory Response Program J. Biol. Chem., November 15, 2002; 277(47): 45129 - 45140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hollinger and J. R. Hepler Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling Pharmacol. Rev., September 1, 2002; 54(3): 527 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. N. Johnson and K. M. Druey Functional Characterization of the G Protein Regulator RGS13 J. Biol. Chem., May 3, 2002; 277(19): 16768 - 16774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Derrien and K. M. Druey RGS16 Function Is Regulated by Epidermal Growth Factor Receptor-mediated Tyrosine Phosphorylation J. Biol. Chem., December 14, 2001; 276(51): 48532 - 48538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Lombardi, A. Kavelaars, P. M. Cobelens, R. E. Schmidt, M. Schedlowski, and C. J. Heijnen Adjuvant Arthritis Induces Down-Regulation of G Protein-Coupled Receptor Kinases in the Immune System J. Immunol., February 1, 2001; 166(3): 1635 - 1640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. S. Kabarowski, J. D. Feramisco, L. Q. Le, J. L. Gu, S.-W. Luoh, M. I. Simon, and O. N. Witte Direct genetic demonstration of Galpha 13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement PNAS, October 24, 2000; 97(22): 12109 - 12114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Sullivan, K. J. Harrison-Lavoie, V. Marshansky, H. Y. Lin, J. H. Kehrl, D. A. Ausiello, D. Brown, and K. M. Druey RGS4 and RGS2 Bind Coatomer and Inhibit COPI Association with Golgi Membranes and Intracellular Transport Mol. Biol. Cell, September 1, 2000; 11(9): 3155 - 3168. [Abstract] [Full Text]
|
|
|
|
|
|
K. Reif and J. G. Cyster RGS Molecule Expression in Murine B Lymphocytes and Ability to Down-Regulate Chemotaxis to Lymphoid Chemokines ,2 J. Immunol., May 1, 2000; 164(9): 4720 - 4729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Grant, B. Lassègue, K. K. Griendling, M. Ushio-Fukai, P. R. Lyons, and R. W. Alexander Specific Regulation of RGS2 Messenger RNA by Angiotensin II in Cultured Vascular Smooth Muscle Cells Mol. Pharmacol., March 1, 2000; 57(3): 460 - 467. [Abstract] [Full Text]
|
|
|
|
|
|
L. Song, P. De Sarno, and R. S. Jope Muscarinic Receptor Stimulation Increases Regulators of G-protein Signaling 2 mRNA Levels through a Protein Kinase C-dependent Mechanism J. Biol. Chem., October 15, 1999; 274(42): 29689 - 29693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I.-K. Park, C. A. Klug, K. Li, L. Jerabek, L. Li, M. Nanamori, R. R. Neubig, L. Hood, I. L. Weissman, and M. F. Clarke Molecular Cloning and Characterization of a Novel Regulator of G-protein Signaling from Mouse Hematopoietic Stem Cells J. Biol. Chem., January 5, 2001; 276(2): 915 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Heximer, H. Lim, J. L. Bernard, and K. J. Blumer Mechanisms Governing Subcellular Localization and Function of Human RGS2 J. Biol. Chem., April 20, 2001; 276(17): 14195 - 14203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, G. W. Peet, D. Balzarano, X. Li, P. Massa, R. W. Barton, and K. B. Marcu Novel NEMO/Ikappa B Kinase and NF-kappa B Target Genes at the Pre-B to Immature B Cell Transition J. Biol. Chem., May 18, 2001; 276(21): 18579 - 18590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Oliveira-dos-Santos, G. Matsumoto, B. E. Snow, D. Bai, F. P. Houston, I. Q. Whishaw, S. Mariathasan, T. Sasaki, A. Wakeham, P. S. Ohashi, et al. Regulation of T cell activation, anxiety, and male aggression by RGS2 PNAS, October 24, 2000; 97(22): 12272 - 12277. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
