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,
*
Laboratory of Cellular Physiology and Immunology,
Laboratory of Immunology, and
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021
TNF-related activation-induced cytokine (TRANCE) is a member of the
TNF family recently identified in activated T cells. We report here
that TRANCE mRNA is constitutively expressed in memory, but not naive,
T cells and in single-positive thymocytes. Upon TCR/CD3 stimulation,
TRANCE mRNA and surface protein expression are rapidly up-regulated in
CD4+ and CD8+ T cells, which can be further
enhanced on CD4+ T cells by CD28-mediated costimulation.
However, TRANCE induction is significantly suppressed when cells are
stimulated in the presence of IL-4, but is not modified in the presence
of IFN-
, IFN-
, TGF-ß, TNF-, or IL-2. High levels of TRANCE
receptor expression are found on mature dendritic cells (DCs). In this
study we show that activated T and B cells also express TRANCE
receptor, but only at low levels. TRANCE, however, does not exert any
significant effect on the proliferation, activation, or survival of
those cells. In DCs, TRANCE induces the expression of proinflammatory
cytokines (IL-6, IL-1) and T cell growth and differentiation factors
(IL-12, IL-15) in addition to enhancing DC survival. Moreover, TRANCE
cooperates with CD40 ligand or TNF- to further increase the
viability of DCs, suggesting that several TNF-related molecules on
activated T cells may cooperatively regulate the function and survival
of DCs to enhance T cell-mediated immune
responses.
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Y. Zhang, Y. Zhang, Y. Wang, M. Ogata, S.-i. Hashimoto, N. Onai, and K. Matsushima Development of dendritic cells in vitro from murine fetal liver-derived lineage phenotype-negative c-kit+ hematopoietic progenitor cells Blood, January 1, 2000; 95(1): 138 - 146. [Abstract] [Full Text] [PDF]
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A. Aicher, G. L. Shu, D. Magaletti, T. Mulvania, A. Pezzutto, A. Craxton, and E. A. Clark Differential Role for p38 Mitogen-Activated Protein Kinase in Regulating CD40-Induced Gene Expression in Dendritic Cells and B Cells J. Immunol., December 1, 1999; 163(11): 5786 - 5795. [Abstract] [Full Text] [PDF]
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D. Ashany, A. Savir, N. Bhardwaj, and K. B. Elkon Dendritic Cells Are Resistant to Apoptosis Through the Fas (CD95/APO-1) Pathway J. Immunol., November 15, 1999; 163(10): 5303 - 5311. [Abstract] [Full Text] [PDF]
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 W. C. Dougall, M. Glaccum, K. Charrier, K. Rohrbach, K. Brasel, T. De Smedt, E. Daro, J. Smith, M. E. Tometsko, C. R. Maliszewski, et al. RANK is essential for osteoclast and lymph node development Genes & Dev., September 15, 1999; 13(18): 2412 - 2424. [Abstract] [Full Text]
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J. R. Arron, M. Vologodskaia, B. R. Wong, M. Naramura, N. Kim, H. Gu, and Y. Choi A Positive Regulatory Role for Cbl Family Proteins in Tumor Necrosis Factor-related Activation-induced Cytokine (TRANCE) and CD40L-mediated Akt Activation J. Biol. Chem., August 3, 2001; 276(32): 30011 - 30017. [Abstract] [Full Text] [PDF]
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N. Kim, P. R. Odgren, D.-K. Kim, S. C. Marks Jr., and Y. Choi Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene PNAS, September 26, 2000; 97(20): 10905 - 10910. [Abstract] [Full Text] [PDF]
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M. Schoppet, K. T. Preissner, and L. C. Hofbauer RANK Ligand and Osteoprotegerin: Paracrine Regulators of Bone Metabolism and Vascular Function Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 549 - 553. [Abstract] [Full Text] [PDF]
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