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CUTTING EDGE |
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Dermatology and
Experimental Immunology, National Cancer Institute, Bethesda, MD 20892
Dendritic cells (DCs) emigrate to regional lymph nodes (LNs) during immune responses via afferent lymphatic channels. Secondary lymphoid-tissue chemokine (SLC), a CC chemokine, is expressed in secondary lymphoid organs and mediates the chemotaxis of lymphocytes and DCs via its receptor, CC chemokine receptor 7 (CCR7). By dual-label fluorescence confocal microscopy, we showed MHC class II-positive cells within SLC-staining lymphatic channels in the mouse dermis. SLC was a potent in vitro chemoattractant for cultured, migratory skin DCs, and it enhanced the emigration of MHC class II-positive DCs from mouse skin explants by an average of 2.5-fold. Mature or cytokine-activated, but not resting, Langerhans cells expressed CCR7 mRNA by RT-PCR. Anti-SLC Abs, but not control or anti-eotaxin Abs, blocked the in vivo migration of 51Cr-labeled, skin-derived DCs from footpads to draining LNs by 50% (n = 9, p < 0.005). Thus, we provide direct evidence that SLC and CCR7 participate in the emigration of DCs from peripheral tissue to LNs via lymphatics.
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M.-T. Wu and S. T. Hwang CXCR5-Transduced Bone Marrow-Derived Dendritic Cells Traffic to B Cell Zones of Lymph Nodes and Modify Antigen-Specific Immune Responses J. Immunol., May 15, 2002; 168(10): 5096 - 5102. [Abstract] [Full Text] [PDF]
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G. Ratzinger, P. Stoitzner, S. Ebner, M. B. Lutz, G. T. Layton, C. Rainer, R. M. Senior, J. M. Shipley, P. Fritsch, G. Schuler, et al. Matrix Metalloproteinases 9 and 2 Are Necessary for the Migration of Langerhans Cells and Dermal Dendritic Cells from Human and Murine Skin J. Immunol., May 1, 2002; 168(9): 4361 - 4371. [Abstract] [Full Text] [PDF]
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M. I. Zimmer, A. T. Larregina, C. M. Castillo, S. Capuano III, L. D. Falo Jr, M. Murphey-Corb, T. A. Reinhart, and S. M. Barratt-Boyes Disrupted homeostasis of Langerhans cells and interdigitating dendritic cells in monkeys with AIDS Blood, April 15, 2002; 99(8): 2859 - 2868. [Abstract] [Full Text] [PDF]
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A. J. Grant, S. Goddard, J. Ahmed-Choudhury, G. Reynolds, D. G. Jackson, M. Briskin, L. Wu, S. G. Hubscher, and D. H. Adams Hepatic Expression of Secondary Lymphoid Chemokine (CCL21) Promotes the Development of Portal-Associated Lymphoid Tissue in Chronic Inflammatory Liver Disease Am. J. Pathol., April 1, 2002; 160(4): 1445 - 1455. [Abstract] [Full Text] [PDF]
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S.-C. Chen, G. Vassileva, D. Kinsley, S. Holzmann, D. Manfra, M. T. Wiekowski, N. Romani, and S. A. Lira Ectopic Expression of the Murine Chemokines CCL21a and CCL21b Induces the Formation of Lymph Node-Like Structures in Pancreas, But Not Skin, of Transgenic Mice J. Immunol., February 1, 2002; 168(3): 1001 - 1008. [Abstract] [Full Text] [PDF]
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 R. Forster, L. Ohl, and G. Henning Lessons Learned From Lymphocytes: CC Chemokine Receptor-7 Involved in Lymphogenic Metastasis of Melanoma J Natl Cancer Inst, November 7, 2001; 93(21): 1588 - 1589. [Full Text] [PDF]
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H. E. Wiley, E. B. Gonzalez, W. Maki, M.-t. Wu, and S. T. Hwang Expression of CC Chemokine Receptor-7 and Regional Lymph Node Metastasis of B16 Murine Melanoma J Natl Cancer Inst, November 7, 2001; 93(21): 1638 - 1643. [Abstract] [Full Text] [PDF]
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G. Pietra, R. Mortarini, G. Parmiani, and A. Anichini Phases of Apoptosis of Melanoma Cells, but not of Normal Melanocytes, Differently Affect Maturation of Myeloid Dendritic Cells Cancer Res., November 1, 2001; 61(22): 8218 - 8226. [Abstract] [Full Text] [PDF]
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A. Bouchon, C. Hernandez-Munain, M. Cella, and M. Colonna A Dap12-Mediated Pathway Regulates Expression of Cc Chemokine Receptor 7 and Maturation of Human Dendritic Cells J. Exp. Med., October 15, 2001; 194(8): 1111 - 1122. [Abstract] [Full Text] [PDF]
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G. M. Halliday and S. Le Transforming growth factor-{beta} produced by progressor tumors inhibits, while IL-10 produced by regressor tumors enhances, Langerhans cell migration from skin Int. Immunol., September 1, 2001; 13(9): 1147 - 1154. [Abstract] [Full Text] [PDF]
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S. Sharma, M. Stolina, L. Zhu, Y. Lin, R. Batra, M. Huang, R. Strieter, and S. M. Dubinett Secondary Lymphoid Organ Chemokine Reduces Pulmonary Tumor Burden in Spontaneous Murine Bronchoalveolar Cell Carcinoma Cancer Res., September 1, 2001; 61(17): 6406 - 6412. [Abstract] [Full Text] [PDF]
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T. Takayama, A. E. Morelli, N. Onai, M. Hirao, K. Matsushima, H. Tahara, and A. W. Thomson Mammalian and Viral IL-10 Enhance C-C Chemokine Receptor 5 but Down-Regulate C-C Chemokine Receptor 7 Expression by Myeloid Dendritic Cells: Impact on Chemotactic Responses and In Vivo Homing Ability J. Immunol., June 15, 2001; 166(12): 7136 - 7143. [Abstract] [Full Text] [PDF]
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R. Abe, S. C. Donnelly, T. Peng, R. Bucala, and C. N. Metz Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites J. Immunol., June 15, 2001; 166(12): 7556 - 7562. [Abstract] [Full Text] [PDF]
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V. Angeli, C. Faveeuw, O. Roye, J. Fontaine, E. Teissier, A. Capron, I. Wolowczuk, M. Capron, and F. Trottein Role of the Parasite-Derived Prostaglandin D2 in the Inhibition of Epidermal Langerhans Cell Migration during Schistosomiasis Infection J. Exp. Med., May 21, 2001; 193(10): 1135 - 1148. [Abstract] [Full Text] [PDF]
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Z. Dembic, J.-A. Rottingen, J. Dellacasagrande, K. Schenck, and B. Bogen Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level Blood, May 1, 2001; 97(9): 2808 - 2814. [Abstract] [Full Text] [PDF]
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D. Yang, Q. Chen, Y. Le, J. M. Wang, and J. J. Oppenheim Differential Regulation of Formyl Peptide Receptor-Like 1 Expression During the Differentiation of Monocytes to Dendritic Cells and Macrophages J. Immunol., March 15, 2001; 166(6): 4092 - 4098. [Abstract] [Full Text] [PDF]
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P. Hjelmström Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines J. Leukoc. Biol., March 1, 2001; 69(3): 331 - 339. [Abstract] [Full Text]
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C. J. Kirk, D. Hartigan-O’Connor, B. J. Nickoloff, J. S. Chamberlain, M. Giedlin, L. Aukerman, and J. J. Mulé T Cell-dependent Antitumor Immunity Mediated by Secondary Lymphoid Tissue Chemokine: Augmentation of Dendritic Cell-based Immunotherapy Cancer Res., March 1, 2001; 61(5): 2062 - 2070. [Abstract] [Full Text]
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M. Itakura, A. Tokuda, H. Kimura, S. Nagai, H. Yoneyama, N. Onai, S. Ishikawa, T. Kuriyama, and K. Matsushima Blockade of Secondary Lymphoid Tissue Chemokine Exacerbates Propionibacterium acnes-Induced Acute Lung Inflammation J. Immunol., February 1, 2001; 166(3): 2071 - 2079. [Abstract] [Full Text] [PDF]
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J. J. Campbell, K. E. Murphy, E. J. Kunkel, C. E. Brightling, D. Soler, Z. Shen, J. Boisvert, H. B. Greenberg, M. A. Vierra, S. B. Goodman, et al. CCR7 Expression and Memory T Cell Diversity in Humans J. Immunol., January 15, 2001; 166(2): 877 - 884. [Abstract] [Full Text] [PDF]
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L. A. Lambert, G. R. Gibson, M. Maloney, B. Durell, R. J. Noelle, and R. J. Barth Jr. Intranodal Immunization with Tumor Lysate-pulsed Dendritic Cells Enhances Protective Antitumor Immunity Cancer Res., January 1, 2001; 61(2): 641 - 646. [Abstract] [Full Text]
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H. Nakano and M. D. Gunn Gene Duplications at the Chemokine Locus on Mouse Chromosome 4: Multiple Strain-Specific Haplotypes and the Deletion of Secondary Lymphoid-Organ Chemokine and EBI-1 Ligand Chemokine Genes in the plt Mutation J. Immunol., January 1, 2001; 166(1): 361 - 369. [Abstract] [Full Text] [PDF]
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G. J. M. Maestroni Dendritic Cell Migration Controlled by {alpha}1b-Adrenergic Receptors J. Immunol., December 15, 2000; 165(12): 6743 - 6747. [Abstract] [Full Text] [PDF]
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P. Schaerli, K. Willimann, A. B. Lang, M. Lipp, P. Loetscher, and B. Moser Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function J. Exp. Med., December 4, 2000; 192(11): 1553 - 1562. [Abstract] [Full Text] [PDF]
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B. Serafini, S. Columba-Cabezas, F. Di Rosa, and F. Aloisi Intracerebral Recruitment and Maturation of Dendritic Cells in the Onset and Progression of Experimental Autoimmune Encephalomyelitis Am. J. Pathol., December 1, 2000; 157(6): 1991 - 2002. [Abstract] [Full Text] [PDF]
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M.-C. Dieu-Nosjean, C. Massacrier, B. Homey, B. Vanbervliet, J.-J. Pin, A. Vicari, S. Lebecque, C. Dezutter-Dambuyant, D. Schmitt, A. Zlotnik, et al. Macrophage Inflammatory Protein 3{alpha} Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors J. Exp. Med., September 5, 2000; 192(5): 705 - 718. [Abstract] [Full Text] [PDF]
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X. Cao, W. Zhang, T. Wan, L. He, T. Chen, Z. Yuan, S. Ma, Y. Yu, and G. Chen Molecular Cloning and Characterization of a Novel CXC Chemokine Macrophage Inflammatory Protein-2{gamma} Chemoattractant for Human Neutrophils and Dendritic Cells J. Immunol., September 1, 2000; 165(5): 2588 - 2595. [Abstract] [Full Text] [PDF]
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D. Yang, Q. Chen, S. Stoll, X. Chen, O. M. Z. Howard, and J. J. Oppenheim Differential Regulation of Responsiveness to fMLP and C5a Upon Dendritic Cell Maturation: Correlation with Receptor Expression J. Immunol., September 1, 2000; 165(5): 2694 - 2702. [Abstract] [Full Text] [PDF]
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M. Merad, L. Fong, J. Bogenberger, and E. G. Engleman Differentiation of myeloid dendritic cells into CD8alpha -positive dendritic cells in vivo Blood, September 1, 2000; 96(5): 1865 - 1872. [Abstract] [Full Text] [PDF]
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A. P. Vicari, S. Ait-Yahia, K. Chemin, A. Mueller, A. Zlotnik, and C. Caux Antitumor Effects of the Mouse Chemokine 6Ckine/SLC Through Angiostatic and Immunological Mechanisms J. Immunol., August 15, 2000; 165(4): 1992 - 2000. [Abstract] [Full Text] [PDF]
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S. K. Bromley, D. A. Peterson, M. D. Gunn, and M. L. Dustin Cutting Edge: Hierarchy of Chemokine Receptor and TCR Signals Regulating T Cell Migration and Proliferation J. Immunol., July 1, 2000; 165(1): 15 - 19. [Abstract] [Full Text] [PDF]
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