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*
Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Göteborg University, Gothenburg, Sweden; and
Gene Therapy Core Center, Cardiovascular Research Institute, Department of Laboratory Medicine, University of California, San Francisco, CA 94143.
IL-17 is a recently discovered cytokine that can be released from
activated human CD4+ T lymphocytes. This study assessed the
proinflammatory effects of human (h) IL-17 in the airways. In vitro,
hIL-17 increased the release of IL-8 in human bronchial epithelial and
venous endothelial cells, in a time- and concentration-dependent
fashion. This effect of hIL-17 was inhibited by cotreatment with an
anti-hIL-17 Ab and was potentiated by hTNF-
. In addition, hIL-17
increased the expression of hIL-8 mRNA in bronchial epithelial cells.
Conditioned medium from hIL-17-treated bronchial epithelial cells
increased human neutrophil migration in vitro. This effect was blocked
by an anti-hIL-8 Ab. In vivo, intratracheal instillation of hIL-17
selectively recruited neutrophils into rat airways. This recruitment of
neutrophils into the airways was inhibited by an anti-hIL-17 Ab and
accompanied by increased levels of rat macrophage inflammatory
protein-2 (rMIP-2) in bronchoalveolar lavage (BAL) fluid. The BAL
neutrophilia was also blocked by an anti-rMIP-2 Ab. The effect of
hIL-17 on the release of hIL-8 and rMIP-2 was also inhibited by
glucocorticoids, in vitro and in vivo, respectively. These data
demonstrate that hIL-17 can specifically and selectively recruit
neutrophils into the airways via the release of C-X-C chemokines from
bronchial epithelial cells and suggest a novel mechanism linking the
activation of T-lymphocytes to recruitment of neutrophils into the
airways.
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E. Lubberts, P. Schwarzenberger, W. Huang, J. R. Schurr, J. J. Peschon, W. B. van den Berg, and J. K. Kolls Requirement of IL-17 Receptor Signaling in Radiation-Resistant Cells in the Joint for Full Progression of Destructive Synovitis J. Immunol., September 1, 2005; 175(5): 3360 - 3368. [Abstract] [Full Text] [PDF]
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W. Ning, A. M. K. Choi, and C. Li Carbon monoxide inhibits IL-17-induced IL-6 production through the MAPK pathway in human pulmonary epithelial cells Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L268 - L273. [Abstract] [Full Text] [PDF]
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M. Laan, O. Prause, M. Miyamoto, M. Sjostrand, A.M. Hytonen, T. Kaneko, J. Lotvall, and A. Linden A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-{alpha} Eur. Respir. J., March 1, 2003; 21(3): 387 - 393. [Abstract] [Full Text] [PDF]
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E. Lubberts, L. van den Bersselaar, B. Oppers-Walgreen, P. Schwarzenberger, C. J. J. Coenen-de Roo, J. K. Kolls, L. A. B. Joosten, and W. B. van den Berg IL-17 Promotes Bone Erosion in Murine Collagen-Induced Arthritis Through Loss of the Receptor Activator of NF-{kappa}B Ligand/Osteoprotegerin Balance J. Immunol., March 1, 2003; 170(5): 2655 - 2662. [Abstract] [Full Text] [PDF]
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J. K. Kolls, S. T. Kanaly, and A. J. Ramsay Interleukin-17: An Emerging Role in Lung Inflammation Am. J. Respir. Cell Mol. Biol., January 1, 2003; 28(1): 9 - 11. [Full Text] [PDF]
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P. W. Hellings, A. Kasran, Z. Liu, P. Vandekerckhove, A. Wuyts, L. Overbergh, C. Mathieu, and J. L. Ceuppens Interleukin-17 Orchestrates the Granulocyte Influx into Airways after Allergen Inhalation in a Mouse Model of Allergic Asthma Am. J. Respir. Cell Mol. Biol., January 1, 2003; 28(1): 42 - 50. [Abstract] [Full Text] [PDF]
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J. Maertzdorf, A. D. M. E. Osterhaus, and G. M. G. M. Verjans IL-17 Expression in Human Herpetic Stromal Keratitis: Modulatory Effects on Chemokine Production by Corneal Fibroblasts J. Immunol., November 15, 2002; 169(10): 5897 - 5903. [Abstract] [Full Text] [PDF]
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S. B. Forlow, E. J. White, K. L. Thomas, G. J. Bagby, P. L. Foley, and K. Ley T Cell Requirement for Development of Chronic Ulcerative Dermatitis in E- and P-Selectin-Deficient Mice J. Immunol., November 1, 2002; 169(9): 4797 - 4804. [Abstract] [Full Text] [PDF]
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M. R. Kim, R. Manoukian, R. Yeh, S. M. Silbiger, D. M. Danilenko, S. Scully, J. Sun, M. L. DeRose, M. Stolina, D. Chang, et al. Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production Blood, September 18, 2002; 100(7): 2330 - 2340. [Abstract] [Full Text] [PDF]
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P J Koshy, N Henderson, C Logan, P F Life, T E Cawston, and A D Rowan Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines Ann Rheum Dis, August 1, 2002; 61(8): 704 - 713. [Abstract] [Full Text] [PDF]
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D. R. Chung, T. Chitnis, R. J. Panzo, D. L. Kasper, M. H. Sayegh, and A. O. Tzianabos CD4+ T Cells Regulate Surgical and Postinfectious Adhesion Formation J. Exp. Med., June 3, 2002; 195(11): 1471 - 1478. [Abstract] [Full Text] [PDF]
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C. E. Jones and K. Chan Interleukin-17 Stimulates the Expression of Interleukin-8, Growth-Related Oncogene-alpha , and Granulocyte-Colony-Stimulating Factor by Human Airway Epithelial Cells Am. J. Respir. Cell Mol. Biol., June 1, 2002; 26(6): 748 - 753. [Abstract] [Full Text] [PDF]
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F. Benchetrit, A. Ciree, V. Vives, G. Warnier, A. Gey, C. Sautes-Fridman, F. Fossiez, N. Haicheur, W. H. Fridman, and E. Tartour Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism Blood, March 15, 2002; 99(6): 2114 - 2121. [Abstract] [Full Text] [PDF]
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S. Aggarwal and A. L. Gurney IL-17: prototype member of an emerging cytokine family J. Leukoc. Biol., January 1, 2002; 71(1): 1 - 8. [Abstract] [Full Text] [PDF]
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G. Pan, D. French, W. Mao, M. Maruoka, P. Risser, J. Lee, J. Foster, S. Aggarwal, K. Nicholes, S. Guillet, et al. Forced Expression of Murine IL-17E Induces Growth Retardation, Jaundice, a Th2-Biased Response, and Multiorgan Inflammation in Mice J. Immunol., December 1, 2001; 167(11): 6559 - 6567. [Abstract] [Full Text] [PDF]
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J.-P. LAVOIE, K. MAGHNI, M. DESNOYERS, R. TAHA, J. G. MARTIN, and Q. A. HAMID Neutrophilic Airway Inflammation in Horses with Heaves Is Characterized by a Th2-type Cytokine Profile Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1410 - 1413. [Abstract] [Full Text] [PDF]
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M. Kawaguchi, L. F. Onuchic, X.-D. Li, D. M. Essayan, J. Schroeder, H.-Q. Xiao, M. C. Liu, G. Krishnaswamy, G. Germino, and S.-K. Huang Identification of a Novel Cytokine, ML-1, and Its Expression in Subjects with Asthma J. Immunol., October 15, 2001; 167(8): 4430 - 4435. [Abstract] [Full Text] [PDF]
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P. Ye, P. B. Garvey, P. Zhang, S. Nelson, G. Bagby, W. R. Summer, P. Schwarzenberger, J. E. Shellito, and J. K. Kolls Interleukin-17 and Lung Host Defense against Klebsiella pneumoniae Infection Am. J. Respir. Cell Mol. Biol., September 1, 2001; 25(3): 335 - 340. [Abstract] [Full Text] [PDF]
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P. Ye, F. H. Rodriguez, S. Kanaly, K. L. Stocking, J. Schurr, P. Schwarzenberger, P. Oliver, W. Huang, P. Zhang, J. Zhang, et al. Requirement of Interleukin 17 Receptor Signaling for Lung CXC Chemokine and Granulocyte Colony-stimulating Factor Expression, Neutrophil Recruitment, and Host Defense J. Exp. Med., August 20, 2001; 194(4): 519 - 528. [Abstract] [Full Text] [PDF]
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E. Lubberts, L. A. B. Joosten, B. Oppers, L. van den Bersselaar, C. J. J. Coenen-de Roo, J. K. Kolls, P. Schwarzenberger, F. A. J. van de Loo, and W. B. van den Berg IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis J. Immunol., July 15, 2001; 167(2): 1004 - 1013. [Abstract] [Full Text] [PDF]
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R. Larsson, D. Rocksen, B. Lilliehook, A. Jonsson, and A. Bucht Dose-Dependent Activation of Lymphocytes in Endotoxin-Induced Airway Inflammation Infect. Immun., December 1, 2000; 68(12): 6962 - 6969. [Abstract] [Full Text] [PDF]
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C. Infante-Duarte, H. F. Horton, M. C. Byrne, and T. Kamradt Microbial Lipopeptides Induce the Production of IL-17 in Th Cells J. Immunol., December 1, 2000; 165(11): 6107 - 6115. [Abstract] [Full Text] [PDF]
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J. Witowski, K. Pawlaczyk, A. Breborowicz, A. Scheuren, M. Kuzlan-Pawlaczyk, J. Wisniewska, A. Polubinska, H. Friess, G. M. Gahl, U. Frei, et al. IL-17 Stimulates Intraperitoneal Neutrophil Infiltration Through the Release of GRO{alpha} Chemokine from Mesothelial Cells J. Immunol., November 15, 2000; 165(10): 5814 - 5821. [Abstract] [Full Text] [PDF]
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F. Luzza, T. Parrello, G. Monteleone, L. Sebkova, M. Romano, R. Zarrilli, M. Imeneo, and F. Pallone Up-Regulation of IL-17 Is Associated with Bioactive IL-8 Expression in Helicobacter pylori-Infected Human Gastric Mucosa J. Immunol., November 1, 2000; 165(9): 5332 - 5337. [Abstract] [Full Text] [PDF]
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Y. Shi, S. J. Ullrich, J. Zhang, K. Connolly, K. J. Grzegorzewski, M. C. Barber, W. Wang, K. Wathen, V. Hodge, C. L. Fisher, et al. A Novel Cytokine Receptor-Ligand Pair. IDENTIFICATION, MOLECULAR CHARACTERIZATION, AND IN VIVO IMMUNOMODULATORY ACTIVITY J. Biol. Chem., June 16, 2000; 275(25): 19167 - 19176. [Abstract] [Full Text] [PDF]
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