| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Section of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan;
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan;
Section of Infectious Diseases, Department of Medicine, Michigan State University, East Lansing, MI 48824; and
§
Department of Medicine, Veterans Affairs Medical Center and University of Oklahoma Health Science Center and Arthritis-Immunology Section, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104
Autoantibodies to five of the aminoacyl-transfer RNA (tRNA) synthetases have been described, and each is associated with a syndrome of inflammatory myopathy with interstitial lung disease (ILD) and arthritis. Serum KS, from a patient with ILD and inflammatory arthritis without evidence of myositis, immunoprecipitated a tRNA that was distinct from that precipitated by any described anti-synthetase or other reported tRNA-related Abs, along with a protein of 65 kDa. KS serum and IgG fraction each showed significant (88%) inhibition of asparaginyl-tRNA synthetase (AsnRS) activity, but not of any of the other 19 aminoacyl-tRNA synthetase activities. Among 884 patients with connective tissue diseases tested, only two other sera were found to immunoprecipitate tRNAs and proteins of identical gel mobility. These two and KS showed identical immunodiffusion lines using HeLa cell extract. The new sera significantly inhibited AsnRS without significant effects on other synthetases tested. Both patients had ILD but neither had evidence of myositis. These data strongly suggest that these three sera have autoantibodies to AsnRS, representing a sixth anti-synthetase. Anti-KS was more closely associated with ILD than with myositis. Further study of this Abs might prove useful in dissecting the stimuli responsible for the genesis of anti-synthetase autoantibodies.
This article has been cited by other articles:
|
|
 |
|
  M. Kalluri, S. A. Sahn, C. V. Oddis, S. L. Gharib, L. Christopher-Stine, S. K. Danoff, L. Casciola-Rosen, G. Hong, P. F. Dellaripa, and K. B. Highland Clinical Profile of Anti-PL-12 Autoantibody: Cohort Study and Review of the Literature Chest, June 1, 2009; 135(6): 1550 - 1556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Gunawardena, Z. E. Betteridge, and N. J. McHugh Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expression Rheumatology, June 1, 2009; 48(6): 607 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Park, P. Schimmel, and S. Kim Aminoacyl tRNA synthetases and their connections to disease PNAS, August 12, 2008; 105(32): 11043 - 11049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Scheffler, U. Kuckelkorn, K. Egerer, T. Dorner, K. Reiter, A. Soza, G.-R. Burmester, and E. Feist Autoimmune reactivity against the 20S-proteasome includes immunosubunits LMP2 ({beta}1i), MECL1 ({beta}2i) and LMP7 ({beta}5i) Rheumatology, May 1, 2008; 47(5): 622 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Betteridge, H. Gunawardena, J. North, J. Slinn, and N. McHugh Anti-synthetase syndrome: a new autoantibody to phenylalanyl transfer RNA synthetase (anti-Zo) associated with polymyositis and interstitial pneumonia Rheumatology, June 1, 2007; 46(6): 1005 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sato, M. Kuwana, and M. Hirakata Clinical characteristics of Japanese patients with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibodies Rheumatology, May 1, 2007; 46(5): 842 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Selva-O'Callaghan, M Labrador-Horrillo, X Munoz-Gall, X Martinez-Gomez, J Majo-Masferrer, R Solans-Laque, C P Simeon-Aznar, F Morell-Brotard, and M Vilardell-Tarres Polymyositis/dermatomyositis-associated lung disease: analysis of a series of 81 patients Lupus, July 1, 2005; 14(7): 534 - 542. [Abstract] [PDF]
|
|
|
|
 |
|
 R Brouwer, G J D Hengstman, W V. Egberts, H Ehrfeld, B Bozic, A Ghirardello, G Grondal, M Hietarinta, D Isenberg, J R Kalden, et al. Autoantibody profiles in the sera of European patients with myositis Ann Rheum Dis, February 1, 2001; 60(2): 116 - 123. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
