| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Microbiology, Oregon State University, Corvallis, OR 97331
In this report we show that activation of APC with an agonist anti-CD40 mAb profoundly alters the behavior of CD4 T cells in vivo. Stimulation of mice with anti-CD40 2 days before, but not 1 day after, administration of superantigen (SAg) enhanced CD4 and CD8 T cell clonal expansion by approximately threefold. Further, CD40 activation also delayed peripheral T cell deletion after activation. Dying, activated T cells were quantitated by detecting extracellular phosphatidylserine with concomitant staining for SAg-reactive T cells using a TCR Vß-specific mAb. Upon close examination, it was shown that CD40 activation delayed the death of the activated T cells. Additionally, it was found that enhanced survival of CD4 T cells was equally dependent on APC expression of B7-1 and B7-2. This is in contrast to CD8 T cells, which did not depend as much on B7-1 as B7-2. Thus, CD40 activation indirectly promotes T cell growth and delays the death of SAg-stimulated CD4 T cells in vivo. These data suggest that one way CD40 activation promotes a more robust immune response is by indirectly increasing the production of effector T cells and by keeping them alive for longer periods of time.
This article has been cited by other articles:
|
|
 |
|
  S. Manicassamy, D. Yin, Z. Zhang, L. L. Molinero, M.-L. Alegre, and Z. Sun A Critical Role for Protein Kinase C-{theta}-Mediated T Cell Survival in Cardiac Allograft Rejection J. Immunol., July 1, 2008; 181(1): 513 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. McAleer, D. J. Zammit, L. Lefrancois, R. J. Rossi, and A. T. Vella The Lipopolysaccharide Adjuvant Effect on T Cells Relies on Nonoverlapping Contributions from the MyD88 Pathway and CD11c+ Cells J. Immunol., November 15, 2007; 179(10): 6524 - 6535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Otahal, B. B. Knowles, S. S. Tevethia, and T. D. Schell Anti-CD40 Conditioning Enhances the TCD8 Response to a Highly Tolerogenic Epitope and Subsequent Immunotherapy of Simian Virus 40 T Antigen-Induced Pancreatic Tumors J. Immunol., November 15, 2007; 179(10): 6686 - 6695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bartholdy, S. O. Kauffmann, J. P. Christensen, and A. R. Thomsen Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus J. Immunol., February 1, 2007; 178(3): 1662 - 1670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Y. Taraban, T. F. Rowley, D. F. Tough, and A. Al-Shamkhani Requirement for CD70 in CD4+ Th Cell-Dependent and Innate Receptor-Mediated CD8+ T Cell Priming. J. Immunol., September 1, 2006; 177(5): 2969 - 2975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. N. Buhtoiarov, H. Lum, G. Berke, D. M. Paulnock, P. M. Sondel, and A. L. Rakhmilevich CD40 Ligation Activates Murine Macrophages via an IFN-{gamma}-Dependent Mechanism Resulting in Tumor Cell Destruction In Vitro J. Immunol., May 15, 2005; 174(10): 6013 - 6022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Y. Taraban, T. F. Rowley, and A. Al-Shamkhani Cutting Edge: A Critical Role for CD70 in CD8 T Cell Priming by CD40-Licensed APCs J. Immunol., December 1, 2004; 173(11): 6542 - 6546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Rossi, G. Muralimohan, J. R. Maxwell, and A. T. Vella Staphylococcal enterotoxins condition cells of the innate immune system for Toll-like receptor 4 stimulation Int. Immunol., December 1, 2004; 16(12): 1751 - 1760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Koschella, D. Voehringer, and H. Pircher CD40 Ligation In Vivo Induces Bystander Proliferation of Memory Phenotype CD8 T Cells J. Immunol., April 15, 2004; 172(8): 4804 - 4811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Ahonen, C. L. Doxsee, S. M. McGurran, T. R. Riter, W. F. Wade, R. J. Barth, J. P. Vasilakos, R. J. Noelle, and R. M. Kedl Combined TLR and CD40 Triggering Induces Potent CD8+ T Cell Expansion with Variable Dependence on Type I IFN J. Exp. Med., March 15, 2004; 199(6): 775 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Maxwell, R. J. Rossi, S. J. McSorley, and A. T. Vella T Cell Clonal Conditioning: A Phase Occurring Early after Antigen Presentation but before Clonal Expansion Is Impacted by Toll-Like Receptor Stimulation J. Immunol., January 1, 2004; 172(1): 248 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Myers, C. Takahashi, R. S. Mittler, R. J. Rossi, and A. T. Vella Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering PNAS, April 29, 2003; 100(9): 5348 - 5353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhai, L. Meng, R. W. Busuttil, M. H. Sayegh, and J. W. Kupiec-Weglinski Activation of Alloreactive CD8+ T Cells Operates Via CD4-Dependent and CD4-Independent Mechanisms and Is CD154 Blockade Sensitive J. Immunol., March 15, 2003; 170(6): 3024 - 3028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. MITCHELL, T. K. TEAGUE, D. A. HILDEMAN, J. BENDER, W. A. REES, R. M. KEDL, B. SWANSON, J. W. KAPPLER, and P. MARRACK Stronger Correlation of bcl-3 than bcl-2, bcl-xL, Costimulation, or Antioxidants with Adjuvant-Induced T Cell Survival Ann. N.Y. Acad. Sci., December 1, 2002; 975(1): 114 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-W. Lee, S.-J. Park, B. K. Choi, H. H. Kim, K.-O. Nam, and B. S. Kwon 4-1BB Promotes the Survival of CD8+ T Lymphocytes by Increasing Expression of Bcl-xL and Bfl-1 J. Immunol., November 1, 2002; 169(9): 4882 - 4888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Maxwell, C. Ruby, N. I. Kerkvliet, and A. T. Vella Contrasting the Roles of Costimulation and the Natural Adjuvant Lipopolysaccharide During the Induction of T Cell Immunity J. Immunol., May 1, 2002; 168(9): 4372 - 4381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Bachmann and M. Kopf On the Role of the Innate Immunity in Autoimmune Disease J. Exp. Med., June 18, 2001; 193(12): F47 - F50. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tan, T. Town, T. Mori, Y. Wu, M. Saxe, F. Crawford, and M. Mullan CD45 Opposes beta -Amyloid Peptide-Induced Microglial Activation via Inhibition of p44/42 Mitogen-Activated Protein Kinase J. Neurosci., October 15, 2000; 20(20): 7587 - 7594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Matthews, M. Wadhwa, C. Bird, F. E. Borras, and C. V. Navarrete Sustained Expression of CD154 (CD40L) and Proinflammatory Cytokine Production by Alloantigen-Stimulated Umbilical Cord Blood T Cells J. Immunol., June 15, 2000; 164(12): 6206 - 6212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Wittig, B. Johansson, M. Zoller, C. Schwarzler, and U. Gunthert Abrogation of Experimental Colitis Correlates with Increased Apoptosis in Mice Deficient for CD44 Variant Exon 7 (CD44v7) J. Exp. Med., June 12, 2000; 191(12): 2053 - 2064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. van Broekhoven, C. R. Parish, G. Vassiliou, and J. G. Altin Engrafting Costimulator Molecules onto Tumor Cell Surfaces with Chelator Lipids: A Potentially Convenient Approach in Cancer Vaccine Development J. Immunol., March 1, 2000; 164(5): 2433 - 2443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lefrancois, J. D. Altman, K. Williams, and S. Olson Soluble Antigen and CD40 Triggering Are Sufficient to Induce Primary and Memory Cytotoxic T Cells J. Immunol., January 15, 2000; 164(2): 725 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Martin, C. L. King, E. Pearlman, E. Strine, and F. P. Heinzel IFN-{gamma} Is Necessary But Not Sufficient for Anti-CD40 Antibody-Mediated Inhibition of the Th2 Response to Schistosoma mansoni Eggs J. Immunol., January 15, 2000; 164(2): 779 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Maxwell, A. Weinberg, R. A. Prell, and A. T. Vella Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion J. Immunol., January 1, 2000; 164(1): 107 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Peoples, B. W. Anderson, T. V. Lee, J. L. Murray, A. P. Kudelka, J. T. Wharton, and C. G. Ioannides Vaccine Implications of Folate Binding Protein, a Novel Cytotoxic T Lymphocyte-recognized Antigen System in Epithelial Cancers Clin. Cancer Res., December 1, 1999; 5(12): 4214 - 4223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Garza, S. M. Chan, R. Suri, L. T. Nguyen, B. Odermatt, S. P. Schoenberger, and P. S. Ohashi Role of Antigen-presenting Cells in Mediating Tolerance and Autoimmunity J. Exp. Med., June 6, 1999; 191(11): 2021 - 2028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Takahashi, R. S. Mittler, and A. T. Vella Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal J. Immunol., May 1, 1999; 162(9): 5037 - 5040. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
