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The Journal of Immunology, 1999, 162: 1789-1794.
Copyright © 1999 by The American Association of Immunologists

Immune-Mediated Destruction of Melanocytes in Halo Nevi Is Associated with the Local Expansion of a Limited Number of T Cell Clones

Philippe Musette1,*,{dagger}, Hervé Bachelez*, Béatrice Flageul*, Christiane Delarbre{dagger}, Philippe Kourilsky{dagger}, Louis Dubertret* and Gabriel Gachelin{dagger}

* Institut de Recherche sur la Peau, Institut National de la Santé et de la Recherche Médicale U312, Hôpital Saint-Louis, Paris, France; and {dagger} Institut Pasteur, Unité de Biologie Moléculaire du Gène, Institut National de la Santé et de la Recherche Médicale U277, Département d’Immunologie, Paris, France

The ß-chain repertoire of the T cells that infiltrate spontaneously regressing nevi (the halo nevus phenomenon) was studied. In addition to the infiltration of the halo nevi by cutaneous lymphocyte-associated Ag-positive lymphocytes, oligoclonal expansion of T cells was observed in all halo nevi of all patients. T cells using the same TCR ß-chain were observed in distinct halo nevi of the same patient but not in his peripheral blood, demonstrating a local expansion of common clones that are most likely activated by the Ag(s) shared by independent halo nevi of the same patient.




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