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Immune-Mediated Destruction of Melanocytes in Halo Nevi Is Associated with the Local Expansion of a Limited Number of T Cell Clones

Philippe Musette^1,*,, Hervé Bachelez^*, Béatrice Flageul^*, Christiane Delarbre, Philippe Kourilsky, Louis Dubertret^* and Gabriel Gachelin

^* Institut de Recherche sur la Peau, Institut National de la Santé et de la Recherche Médicale U312, Hôpital Saint-Louis, Paris, France; and Institut Pasteur, Unité de Biologie Moléculaire du Gène, Institut National de la Santé et de la Recherche Médicale U277, Département d’Immunologie, Paris, France

The ß-chain repertoire of the T cells that infiltrate spontaneously regressing nevi (the halo nevus phenomenon) was studied. In addition to the infiltration of the halo nevi by cutaneous lymphocyte-associated Ag-positive lymphocytes, oligoclonal expansion of T cells was observed in all halo nevi of all patients. T cells using the same TCR ß-chain were observed in distinct halo nevi of the same patient but not in his peripheral blood, demonstrating a local expansion of common clones that are most likely activated by the Ag(s) shared by independent halo nevi of the same patient.

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