| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Biochemical Pharmacology, The William Harvey Research Institute, London, United Kingdom; and
Division of Critical Care Medicine, Children’s Hospital Medical Center, Cincinnati, OH 45229
The roles played by resident macrophages (M
) and mast cells
(MCs) in polymorphonuclear leukocyte (PMN) accumulation and chemokine
production within the mouse peritoneal cavity in response to
administration of zymosan (0.2 and 1 mg), LPS (1 mg/kg), and
thioglycolate (0.5 ml of a 3% suspension) were investigated. A marked
reduction (>95%) in intact MC numbers was obtained by pretreatment
with the MC activator compound 48/80, whereas resident M were
greatly diminished (>85%) by a 3-day treatment with liposomes
encapsulating the cytotoxic drug dichloromethylene-bisphosphonate. No
modulation of thioglycolate-induced inflammation was seen with either
pretreatment. Removal of either MCs or M attenuated LPS-induced PMN
extravasation without affecting the levels of the chemokines murine
monocyte chemoattractant protein-1 and KC measured in the lavage
fluids. In contrast, MC depletion inhibited PMN accumulation and murine
monocyte chemoattractant protein-1 and KC production in the zymosan
peritonitis model. Removal of M augmented the accumulation of PMN
elicited by the latter stimulus. This was due to an inhibitory action
of M-derived IL-10 because there was 1) a time-dependent release of
IL-10 in the zymosan exudates; 2) a reduction in IL-10 levels following
M, but not MC, depletion; and 3) an increased PMN influx and
chemokine production in IL-10 knockout mice. In conclusion, we propose
a stimulus-dependent role of resident MCs in chemokine production and
the existence of a regulatory loop between endogenous IL-10 and the
chemokine-mediated cellular component of acute
inflammation.
This article has been cited by other articles:
|
|
 |
|
  E. Kolaczkowska, W. Grzybek, N. van Rooijen, H. Piccard, B. Plytycz, B. Arnold, and G. Opdenakker Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis J. Leukoc. Biol., March 1, 2009; 85(3): 374 - 381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Hu, F. Venet, D. S. Heffernan, Y. L. Wang, B. Horner, X. Huang, C.-S. Chung, S. H. Gregory, and A. Ayala The Role of Hepatic Invariant NKT Cells in Systemic/Local Inflammation and Mortality during Polymicrobial Septic Shock J. Immunol., February 15, 2009; 182(4): 2467 - 2475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Paul-Clark, S. K. McMaster, R. Sorrentino, S. Sriskandan, L. K. Bailey, L. Moreno, B. Ryffel, V. F. Quesniaux, and J. A. Mitchell Toll-like Receptor 2 Is Essential for the Sensing of Oxidants during Inflammation Am. J. Respir. Crit. Care Med., February 15, 2009; 179(4): 299 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Leendertse, R. J.L. Willems, I. A.J. Giebelen, J. J.T.H. Roelofs, N. van Rooijen, M. J.M. Bonten, and T. van der Poll Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice Innate Immunity, February 1, 2009; 15(1): 3 - 12. [Abstract] [PDF]
|
|
|
|
 |
|
 X. Qiu, L. Zhu, and J. W. Pollard Colony-Stimulating Factor-1-Dependent Macrophage Functions Regulate the Maternal Decidua Immune Responses against Listeria monocytogenes Infections during Early Gestation in Mice Infect. Immun., January 1, 2009; 77(1): 85 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Dean, J. H. Cox, C. L. Bellac, A. Doucet, A. E. Starr, and C. M. Overall Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx Blood, October 15, 2008; 112(8): 3455 - 3464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rajakariar, M. Hilliard, T. Lawrence, S. Trivedi, P. Colville-Nash, G. Bellingan, D. Fitzgerald, M. M. Yaqoob, and D. W. Gilroy From the Cover: Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxy{Delta}12-14 PGJ2 PNAS, December 26, 2007; 104(52): 20979 - 20984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Burke, L. M. Ganley-Leal, A. Khatri, and L. M. Wetzler Neisseria meningitidis PorB, a TLR2 Ligand, Induces an Antigen-Specific Eosinophil Recall Response: Potential Adjuvant for Helminth Vaccines? J. Immunol., September 1, 2007; 179(5): 3222 - 3230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A Mitchell, M. J Paul-Clark, G. W Clarke, S. K McMaster, and N. Cartwright Critical role of toll-like receptors and nucleotide oligomerisation domain in the regulation of health and disease J. Endocrinol., June 1, 2007; 193(3): 323 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. N. Tziakas, G. K. Chalikias, C. O. Antonoglou, S. Veletza, I. K. Tentes, A. X. Kortsaris, D. I. Hatseras, and J. C. Kaski Apolipoprotein E Genotype and Circulating Interleukin-10 Levels in Patients With Stable and Unstable Coronary Artery Disease J. Am. Coll. Cardiol., December 19, 2006; 48(12): 2471 - 2481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Mullaly and P. Kubes The Role of TLR2 In Vivo following Challenge with Staphylococcus aureus and Prototypic Ligands J. Immunol., December 1, 2006; 177(11): 8154 - 8163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kolaczkowska, A. Scislowska-Czarnecka, M. Chadzinska, B. Plytycz, N. van Rooijen, G. Opdenakker, and B. Arnold Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage origin J. Leukoc. Biol., July 1, 2006; 80(1): 125 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Damazo, S. Yona, R. J. Flower, M. Perretti, and S. M. Oliani Spatial and Temporal Profiles for Anti-Inflammatory Gene Expression in Leukocytes during a Resolving Model of Peritonitis J. Immunol., April 1, 2006; 176(7): 4410 - 4418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nakayama, N. Mutsuga, L. Yao, and G. Tosato Prostaglandin E2 promotes degranulation-independent release of MCP-1 from mast cells J. Leukoc. Biol., January 1, 2006; 79(1): 95 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Chatterjee, S. Yona, G. Rosignoli, R. E. Young, S. Nourshargh, R. J. Flower, and M. Perretti Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro J. Leukoc. Biol., September 1, 2005; 78(3): 639 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Matsukawa, S. Kudo, T. Maeda, K. Numata, H. Watanabe, K. Takeda, S. Akira, and T. Ito Stat3 in Resident Macrophages as a Repressor Protein of Inflammatory Response J. Immunol., September 1, 2005; 175(5): 3354 - 3359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Nasser, R. J. Marjoram, S. L. Brown, and R. M. Richardson Cross-Desensitization among CXCR1, CXCR2, and CCR5: Role of Protein Kinase C-{epsilon} J. Immunol., June 1, 2005; 174(11): 6927 - 6933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Cailhier, M. Partolina, S. Vuthoori, S. Wu, K. Ko, S. Watson, J. Savill, J. Hughes, and R. A. Lang Conditional Macrophage Ablation Demonstrates That Resident Macrophages Initiate Acute Peritoneal Inflammation J. Immunol., February 15, 2005; 174(4): 2336 - 2342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.A. Silva, V.S. Lara, J.S. Silva, S.H.P. Oliveira, W.T. Butler, and F.Q. Cunha Macrophages and Mast Cells Control the Neutrophil Migration Induced by Dentin Proteins Journal of Dental Research, January 1, 2005; 84(1): 79 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bossi, F. Fischetti, V. Pellis, R. Bulla, E. Ferrero, T. E. Mollnes, D. Regoli, and F. Tedesco Platelet-Activating Factor and Kinin-Dependent Vascular Leakage as a Novel Functional Activity of the Soluble Terminal Complement Complex J. Immunol., December 1, 2004; 173(11): 6921 - 6927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Matzer, F. Rodel, R. M. Strieter, M. Rollinghoff, and H. U. Beuscher Constitutive expression of CXCL2/MIP-2 is restricted to a Gr-1high, CD11b+, CD62Lhigh subset of bone marrow derived granulocytes Int. Immunol., November 1, 2004; 16(11): 1675 - 1683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-B. Kang, T. Ben-Moshe, E. E. Varfolomeev, Y. Pewzner-Jung, N. Yogev, A. Jurewicz, A. Waisman, O. Brenner, R. Haffner, E. Gustafsson, et al. Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles J. Immunol., September 1, 2004; 173(5): 2976 - 2984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Lomas-Neira, C.-S. Chung, P. S. Grutkoski, E. J. Miller, and A. Ayala CXCR2 inhibition suppresses hemorrhage-induced priming for acute lung injury in mice J. Leukoc. Biol., July 1, 2004; 76(1): 58 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Stefanidakis, T. Ruohtula, N. Borregaard, C. G. Gahmberg, and E. Koivunen Intracellular and Cell Surface Localization of a Complex between {alpha}M{beta}2 Integrin and Promatrix Metalloproteinase-9 Progelatinase in Neutrophils J. Immunol., June 1, 2004; 172(11): 7060 - 7068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takeshita, T. Yamasaki, S. Akira, F. Gantner, and K. B. Bacon Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse Int. Immunol., May 1, 2004; 16(5): 685 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Thurmond, P. J. Desai, P. J. Dunford, W.-P. Fung-Leung, C. L. Hofstra, W. Jiang, S. Nguyen, J. P. Riley, S. Sun, K. N. Williams, et al. A Potent and Selective Histamine H4 Receptor Antagonist with Anti-Inflammatory Properties J. Pharmacol. Exp. Ther., April 1, 2004; 309(1): 404 - 413. [Abstract] [Full Text]
|
|
|
|
|
|
B. T. Edelson, Z. Li, L. K. Pappan, and M. M. Zutter Mast cell-mediated inflammatory responses require the {alpha}2{beta}1 integrin Blood, March 15, 2004; 103(6): 2214 - 2220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Di Filippo, F. Rossi, S. Rossi, and M. D'Amico Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN J. Leukoc. Biol., March 1, 2004; 75(3): 453 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Willment, H.-H. Lin, D. M. Reid, P. R. Taylor, D. L. Williams, S. Y. C. Wong, S. Gordon, and G. D. Brown Dectin-1 Expression and Function Are Enhanced on Alternatively Activated and GM-CSF-Treated Macrophages and Are Negatively Regulated by IL-10, Dexamethasone, and Lipopolysaccharide J. Immunol., November 1, 2003; 171(9): 4569 - 4573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Murata, M. Inami, A. Hasegawa, S. Kubo, M. Kimura, M. Yamashita, H. Hosokawa, T. Nagao, K. Suzuki, K. Hashimoto, et al. CD69-null mice protected from arthritis induced with anti-type II collagen antibodies Int. Immunol., August 1, 2003; 15(8): 987 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hadjur and F. R. Jirik Increased sensitivity of Fancc-deficient hematopoietic cells to nitric oxide and evidence that this species mediates growth inhibition by cytokines Blood, May 15, 2003; 101(10): 3877 - 3884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Garhart, F. P. Heinzel, S. J. Czinn, and J. G. Nedrud Vaccine-Induced Reduction of Helicobacter pylori Colonization in Mice Is Interleukin-12 Dependent but Gamma Interferon and Inducible Nitric Oxide Synthase Independent Infect. Immun., February 1, 2003; 71(2): 910 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schramm, T. Schaefer, M. D. Menger, and H. Thorlacius Acute mast cell-dependent neutrophil recruitment in the skin is mediated by KC and LFA-1: inhibitory mechanisms of dexamethasone J. Leukoc. Biol., December 1, 2002; 72(6): 1122 - 1132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. HUBER-LANG, N. C. RIEDEMAN, J. V. SARMA, E. M. YOUNKIN, S. R. McGUIRE, I. J. LAUDES, K. T. LU, R.-F. GUO, T. A. NEFF, V. A. PADGAONKAR, et al. Protection of innate immunity by C5aR antagonist in septic mice FASEB J, October 1, 2002; 16(12): 1567 - 1574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kurosaka, N. Watanabe, and Y. Kobayashi Potentiation by human serum of anti-inflammatory cytokine production by human macrophages in response to apoptotic cells J. Leukoc. Biol., June 1, 2002; 71(6): 950 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dobrina, M. Pausa, F. Fischetti, R. Bulla, E. Vecile, E. Ferrero, A. Mantovani, and F. Tedesco Cytolytically inactive terminal complement complex causes transendothelial migration of polymorphonuclear leukocytes in vitro and in vivo Blood, January 1, 2002; 99(1): 185 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. de Coupade, M. N. Ajuebor, F. Russo-Marie, M. Perretti, and E. Solito Cytokine Modulation of Liver Annexin 1 Expression during Experimental Endotoxemia Am. J. Pathol., October 1, 2001; 159(4): 1435 - 1443. [Abstract] [Full Text]
|
|
|
|
|
|
M. Delgado and D. Ganea Inhibition of Endotoxin-Induced Macrophage Chemokine Production by Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide In Vitro and In Vivo J. Immunol., July 15, 2001; 167(2): 966 - 975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Deckert, S. Soltek, G. Geginat, S. Lutjen, M. Montesinos-Rongen, H. Hof, and D. Schluter Endogenous Interleukin-10 Is Required for Prevention of a Hyperinflammatory Intracerebral Immune Response in Listeria monocytogenes Meningoencephalitis Infect. Immun., July 1, 2001; 69(7): 4561 - 4571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Guleria and J. W. Pollard Aberrant Macrophage and Neutrophil Population Dynamics and Impaired Th1 Response to Listeria monocytogenes in Colony-Stimulating Factor 1-Deficient Mice Infect. Immun., March 1, 2001; 69(3): 1795 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ikeda, H. Saito, K. Fukatsu, T. Inoue, I. Han, S. Furukawa, T. Matsuda, and A. Hidemura Dietary Restriction Impairs Neutrophil Exudation by Reducing CD11b/CD18 Expression and Chemokine Production Arch Surg, March 1, 2001; 136(3): 297 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kolaczkowska, R. Seljelid, and B. Plytycz Role of mast cells in zymosan-induced peritoneal inflammation in Balb/c and mast cell-deficient WBB6F1 mice J. Leukoc. Biol., January 1, 2001; 69(1): 33 - 42. [Abstract] [Full Text]
|
|
|
|
|
|
J. Witowski, K. Pawlaczyk, A. Breborowicz, A. Scheuren, M. Kuzlan-Pawlaczyk, J. Wisniewska, A. Polubinska, H. Friess, G. M. Gahl, U. Frei, et al. IL-17 Stimulates Intraperitoneal Neutrophil Infiltration Through the Release of GRO{alpha} Chemokine from Mesothelial Cells J. Immunol., November 15, 2000; 165(10): 5814 - 5821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Terkeltaub IL-10: An "Immunologic Scalpel" for Atherosclerosis? Arterioscler. Thromb. Vasc. Biol., December 1, 1999; 19(12): 2823 - 2825. [Full Text] [PDF]
|
|
|
|
|
|
N. Vergnolle Proteinase-Activated Receptor-2-Activating Peptides Induce Leukocyte Rolling, Adhesion, and Extravasation In Vivo J. Immunol., November 1, 1999; 163(9): 5064 - 5069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Warny, S. Aboudola, S. C. Robson, J. Sevigny, D. Communi, S. P. Soltoff, and C. P. Kelly P2Y6 Nucleotide Receptor Mediates Monocyte Interleukin-8 Production in Response to UDP or Lipopolysaccharide J. Biol. Chem., July 6, 2001; 276(28): 26051 - 26056. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
