| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy; and
Albert Einstein College of Medicine, Bronx, NY 10461
IL-12 production mediated by a T cell-independent and/or T
cell-dependent pathway was investigated in human monocytes responding
to Cryptococcus neoformans. The data of this study
showed that: 1) appreciable levels of IL-12 were observed when freshly
isolated monocytes were exposed to acapsular C.
neoformans or Candida albicans and secretion
occurred within 24–48 h of incubation; 2) monocytes alone were poor
producers of IL-12 when stimulated with encapsulated C.
neoformans; 3) the presence of specific
anti-glucuronoxylomannan mAb favored IL-12 secretion and Fc
cross-linking could play a role; 4) monocytes were able to secrete
consistent levels of IL-12 when cultured with activated T cells
responding to C. neoformans; 5) the maximum secretion of
IL-12 was observed at 5–7 days of culture and was strongly regulated
by the presence of endogenous IFN-
; and 6) the interaction between
CD40 on monocytes and CD40 ligand on activated T lymphocytes responding
to C. neoformans played a critical role in IL-12
secretion. These data highlight the mechanisms of IL-12 production by
human monocytes exposed to C. neoformans, indicating a
possible biphasic secretion of IL-12, dependent on the direct effect of
fungal insult, and characterized by consistent secretion of IL-12 that
is dependent on the interaction of CD40 with the CD40 ligand expressed
on activated T cells responding to C.
neoformans.
This article has been cited by other articles:
|
|
 |
|
  C. Monari, S. Bevilacqua, M. Piccioni, E. Pericolini, S. Perito, M. Calvitti, F. Bistoni, T. R. Kozel, and A. Vecchiarelli A Microbial Polysaccharide Reduces the Severity of Rheumatoid Arthritis by Influencing Th17 Differentiation and Proinflammatory Cytokines Production J. Immunol., July 1, 2009; 183(1): 191 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Monari, T. R. Kozel, F. Paganelli, E. Pericolini, S. Perito, F. Bistoni, A. Casadevall, and A. Vecchiarelli Microbial Immune Suppression Mediated by Direct Engagement of Inhibitory Fc Receptor J. Immunol., November 15, 2006; 177(10): 6842 - 6851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T M Beach and M M Whalen Effects of organochlorine pesticides on interleukin secretion from lymphocytes Human and Experimental Toxicology, November 1, 2006; 25(11): 651 - 659. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Cermelli, V. Cenacchi, F. Beretti, F. Pezzini, D. D. Luca, and E. Blasi Human herpesvirus-6 dysregulates monocyte-mediated anticryptococcal defences J. Med. Microbiol., June 1, 2006; 55(6): 695 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Monari, E. Pericolini, G. Bistoni, A. Casadevall, T. R. Kozel, and A. Vecchiarelli Cryptococcus neoformans Capsular Glucuronoxylomannan Induces Expression of Fas Ligand in Macrophages J. Immunol., March 15, 2005; 174(6): 3461 - 3468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tang, L. Liu, K. Kang, P. K. Mukherjee, M. Takahara, G. Chen, T. S. McCormick, K. D. Cooper, and M. Ghannoum Inhibition of Monocytic Interleukin-12 Production by Candida albicans via Selective Activation of ERK Mitogen-Activated Protein Kinase Infect. Immun., May 1, 2004; 72(5): 2513 - 2520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. R. Humphreys, L. Edwards, G. Walzl, A. J. Rae, G. Dougan, S. Hill, and T. Hussell OX40 Ligation on Activated T Cells Enhances the Control of Cryptococcus neoformans and Reduces Pulmonary Eosinophilia J. Immunol., June 15, 2003; 170(12): 6125 - 6132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pirhonen, S. Matikainen, and I. Julkunen Regulation of Virus-Induced IL-12 and IL-23 Expression in Human Macrophages J. Immunol., November 15, 2002; 169(10): 5673 - 5678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Retini, T. R. Kozel, D. Pietrella, C. Monari, F. Bistoni, and A. Vecchiarelli Interdependency of Interleukin-10 and Interleukin-12 in Regulation of T-Cell Differentiation and Effector Function of Monocytes in Response to Stimulation with Cryptococcus neoformans Infect. Immun., October 1, 2001; 69(10): 6064 - 6073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Qadir, A. Metwali, A. M. Blum, J. Li, D. E. Elliott, and J. V. Weinstock TGF-beta and IL-10 regulation of IFN-gamma produced in Th2-type schistosome granulomas requires IL-12 Am J Physiol Gastrointest Liver Physiol, October 1, 2001; 281(4): G940 - G946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pietrella, R. Cherniak, C. Strappini, S. Perito, P. Mosci, F. Bistoni, and A. Vecchiarelli Role of Mannoprotein in Induction and Regulation of Immunity to Cryptococcus neoformans Infect. Immun., May 1, 2001; 69(5): 2808 - 2814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pitzurra, R. Cherniak, M. Giammarioli, S. Perito, F. Bistoni, and A. Vecchiarelli Early Induction of Interleukin-12 by Human Monocytes Exposed to Cryptococcus neoformans Mannoproteins Infect. Immun., February 1, 2000; 68(2): 558 - 563. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
