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*
R & D Center, BioMedical Laboratories, Kawagoe, Saitama, Japan;
Shionogi Institute for Medical Science, Settsu, Osaka, Japan;
Department of Microbiology and Immunology, Tohoku University School of Medicine, Sendai, Miyagi, Japan; and
§
Human Gene Sciences Center, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
The search for reliable marker molecules discriminating between
human Th1 and Th2 cells identified a gene encoding a novel member of
the G protein-coupled leukocyte chemoattractant receptor family, which
is selectively expressed in Th2 but not Th1 lineage cells, thereby
named CRTH2 (chemoattractant receptor-homologous molecule expressed on
Th2 cells). Studies with anti-CRTH2 mAbs demonstrated that CRTH2
was expressed in a small population (0.4–6.5%) of CD4+ T
cells in fresh PBMCs of healthy adults, but no remarkable expression
was seen in B cells and NK cells. In some cases, CD8+ T
cells (
3.5%) expressed CRTH2. Phenotypes of CD4+ T
cells expressing CRTH2 were CD45RA-, CD45RO+,
and CD25+, similar to those of Ag-activated effector/memory
T cells. Freshly isolated CRTH2+ CD4+ T cells
produced Th2- but little or no Th1-type cytokines upon stimulation with
PMA and ionomycin. In addition, an allergen-induced proliferative
response in fresh PBMCs was significantly and selectively reduced by
subtracting CRTH2+ cells. Together, these results indicate
that CRTH2 is selectively expressed in vivo in an activated state of
Th2 cells including allergen-responsive Th2 cells, suggesting its
pivotal roles in ongoing Th2-type immune
reactions.
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G. Walzl, S. Matthews, S. Kendall, J. C. Gutierrez-Ramos, A. J. Coyle, P. J.M. Openshaw, and T. Hussell Inhibition of T1/St2 during Respiratory Syncytial Virus Infection Prevents T Helper Cell Type 2 (Th2)- but Not Th1-Driven Immunopathology J. Exp. Med., April 2, 2001; 193(7): 785 - 792. [Abstract] [Full Text] [PDF]
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S. Nagai, S.-i. Hashimoto, T. Yamashita, N. Toyoda, T. Satoh, T. Suzuki, and K. Matsushima Comprehensive gene expression profile of human activated Th1- and Th2-polarized cells Int. Immunol., March 1, 2001; 13(3): 367 - 376. [Abstract] [Full Text] [PDF]
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H. Hirai, K. Tanaka, O. Yoshie, K. Ogawa, K. Kenmotsu, Y. Takamori, M. Ichimasa, K. Sugamura, M. Nakamura, S. Takano, et al. Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2 J. Exp. Med., January 15, 2001; 193(2): 255 - 262. [Abstract] [Full Text] [PDF]
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K. Tanaka, K. Ogawa, K. Sugamura, M. Nakamura, S. Takano, and K. Nagata Cutting Edge: Differential Production of Prostaglandin D2 by Human Helper T Cell Subsets J. Immunol., March 1, 2000; 164(5): 2277 - 2280. [Abstract] [Full Text] [PDF]
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K. Murata, N. Ishii, H. Takano, S. Miura, L. C. Ndhlovu, M. Nose, T. Noda, and K. Sugamura Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand J. Exp. Med., January 17, 2000; 191(2): 365 - 374. [Abstract] [Full Text] [PDF]
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