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*
R & D Center, BioMedical Laboratories, Kawagoe, Saitama, Japan;
Shionogi Institute for Medical Science, Settsu, Osaka, Japan;
Department of Microbiology and Immunology, Tohoku University School of Medicine, Sendai, Miyagi, Japan; and
§
Human Gene Sciences Center, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
The search for reliable marker molecules discriminating between
human Th1 and Th2 cells identified a gene encoding a novel member of
the G protein-coupled leukocyte chemoattractant receptor family, which
is selectively expressed in Th2 but not Th1 lineage cells, thereby
named CRTH2 (chemoattractant receptor-homologous molecule expressed on
Th2 cells). Studies with anti-CRTH2 mAbs demonstrated that CRTH2
was expressed in a small population (0.4–6.5%) of CD4+ T
cells in fresh PBMCs of healthy adults, but no remarkable expression
was seen in B cells and NK cells. In some cases, CD8+ T
cells (
3.5%) expressed CRTH2. Phenotypes of CD4+ T
cells expressing CRTH2 were CD45RA-, CD45RO+,
and CD25+, similar to those of Ag-activated effector/memory
T cells. Freshly isolated CRTH2+ CD4+ T cells
produced Th2- but little or no Th1-type cytokines upon stimulation with
PMA and ionomycin. In addition, an allergen-induced proliferative
response in fresh PBMCs was significantly and selectively reduced by
subtracting CRTH2+ cells. Together, these results indicate
that CRTH2 is selectively expressed in vivo in an activated state of
Th2 cells including allergen-responsive Th2 cells, suggesting its
pivotal roles in ongoing Th2-type immune
reactions.
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H. Hirai, K. Tanaka, S. Takano, M. Ichimasa, M. Nakamura, and K. Nagata Cutting Edge: Agonistic Effect of Indomethacin on a Prostaglandin D2 Receptor, CRTH2 J. Immunol., February 1, 2002; 168(3): 981 - 985. [Abstract] [Full Text] [PDF]
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Y. Fujitani, Y. Kanaoka, K. Aritake, N. Uodome, K. Okazaki-Hatake, and Y. Urade Pronounced Eosinophilic Lung Inflammation and Th2 Cytokine Release in Human Lipocalin-Type Prostaglandin D Synthase Transgenic Mice J. Immunol., January 1, 2002; 168(1): 443 - 449. [Abstract] [Full Text] [PDF]
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K. Hase, K. Tani, T. Shimizu, Y. Ohmoto, K. Matsushima, and S. Sone Increased CCR4 expression in active systemic lupus erythematosus J. Leukoc. Biol., November 1, 2001; 70(5): 749 - 755. [Abstract] [Full Text] [PDF]
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G. Monneret, S. Gravel, M. Diamond, J. Rokach, and W. S. Powell Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor Blood, September 15, 2001; 98(6): 1942 - 1948. [Abstract] [Full Text] [PDF]
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W. L. Chan, N. Pejnovic, C. A. Lee, and N. A. Al-Ali Human IL-18 Receptor and ST2L Are Stable and Selective Markers for the Respective Type 1 and Type 2 Circulating Lymphocytes J. Immunol., August 1, 2001; 167(3): 1238 - 1244. [Abstract] [Full Text] [PDF]
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K. Ogawa, K. Tanaka, A. Ishii, Y. Nakamura, S. Kondo, K. Sugamura, S. Takano, M. Nakamura, and K. Nagata A Novel Serum Protein That Is Selectively Produced by Cytotoxic Lymphocytes J. Immunol., May 15, 2001; 166(10): 6404 - 6412. [Abstract] [Full Text] [PDF]
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G. Walzl, S. Matthews, S. Kendall, J. C. Gutierrez-Ramos, A. J. Coyle, P. J.M. Openshaw, and T. Hussell Inhibition of T1/ST2 during Respiratory Syncytial Virus Infection Prevents T Helper Cell Type 2 (Th2)- but not Th1-driven Immunopathology J. Exp. Med., March 26, 2001; 193(7): 785 - 792. [Abstract] [Full Text] [PDF]
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S. Nagai, S.-i. Hashimoto, T. Yamashita, N. Toyoda, T. Satoh, T. Suzuki, and K. Matsushima Comprehensive gene expression profile of human activated Th1- and Th2-polarized cells Int. Immunol., March 1, 2001; 13(3): 367 - 376. [Abstract] [Full Text] [PDF]
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T. Yokomizo, K. Kato, K. Terawaki, T. Izumi, and T. Shimizu A Second Leukotriene B4 Receptor, BLT2: A New Therapeutic Target in Inflammation and Immunological Disorders J. Exp. Med., August 8, 2000; 192(3): 421 - 432. [Abstract] [Full Text] [PDF]
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K. Tanaka, K. Ogawa, K. Sugamura, M. Nakamura, S. Takano, and K. Nagata Cutting Edge: Differential Production of Prostaglandin D2 by Human Helper T Cell Subsets J. Immunol., March 1, 2000; 164(5): 2277 - 2280. [Abstract] [Full Text] [PDF]
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K. Murata, N. Ishii, H. Takano, S. Miura, L. C. Ndhlovu, M. Nose, T. Noda, and K. Sugamura Impairment of Antigen-presenting Cell Function in Mice Lacking Expression of OX40 Ligand J. Exp. Med., January 17, 2000; 191(2): 365 - 374. [Abstract] [Full Text] [PDF]
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S. Wang, E. Gustafson, L. Pang, X. Qiao, J. Behan, M. Maguire, M. Bayne, and T. Laz A Novel Hepatointestinal Leukotriene B4 Receptor. CLONING AND FUNCTIONAL CHARACTERIZATION J. Biol. Chem., December 22, 2000; 275(52): 40686 - 40694. [Abstract] [Full Text] [PDF]
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