| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
Departments of
*
Microbiology/Immunology and
Pathology/Laboratory Medicine, University of Kentucky, Lexington, KY 40536; and
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599
The polymeric IgR (pIgR) mediates transcytosis of
IgA across epithelial barriers of mucous membranes and exocrine glands.
Synthesis of pIgR is up-regulated by the proinflammatory cytokines
TNF-
, IFN-
, and IL-1 in HT-29 human colon carcinoma cells. We
previously reported that IFN- and TNF- induce production of the
transcription factor IFN regulatory factor-1 (IRF-1) in HT-29 cells and
that IRF-1 binds to an element in exon 1 of the PIGR
gene. We now report that levels of IRF-1 and pIgR mRNA are coordinately
regulated in HT-29 cells by TNF-, IFN-, and IL-1ß. Furthermore,
we demonstrate that in vivo expression of pIgR mRNA is greatly
depressed in the intestine and liver of IRF-1-deficient mice. Our
findings indicate a major role for the IRF-1 transcription factor in
regulation of the PIGR gene and suggest a model for
regulation of important genes in the mucosal immune system by
proinflammatory cytokines.
This article has been cited by other articles:
|
|
 |
|
  B. J. Davids, J. E. D. Palm, M. P. Housley, J. R. Smith, Y. S. Andersen, M. G. Martin, B. A. Hendrickson, F.-E. Johansen, S. G. Svard, F. D. Gillin, et al. Polymeric Immunoglobulin Receptor in Intestinal Immune Defense against the Lumen-Dwelling Protozoan Parasite Giardia J. Immunol., November 1, 2006; 177(9): 6281 - 6290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dongari-Bagtzoglou and P.L. Fidel Jr. The Host Cytokine Responses and Protective Immunity in Oropharyngeal Candidiasis Journal of Dental Research, November 1, 2005; 84(11): 966 - 977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Pal, C. S. Kaetzel, K. Brundage, C. A. Cunningham, and C. F. Cuff Regulation of polymeric immunoglobulin receptor expression by reovirus J. Gen. Virol., August 1, 2005; 86(8): 2347 - 2357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Schneeman, M. E. C. Bruno, H. Schjerven, F.-E. Johansen, L. Chady, and C. S. Kaetzel Regulation of the Polymeric Ig Receptor by Signaling through TLRs 3 and 4: Linking Innate and Adaptive Immune Responses J. Immunol., July 1, 2005; 175(1): 376 - 384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. C. Bruno and C. S. Kaetzel Long-Term Exposure of the HT-29 Human Intestinal Epithelial Cell Line to TNF Causes Sustained Up-Regulation of the Polymeric Ig Receptor and Proinflammatory Genes through Transcriptional and Posttranscriptional Mechanisms J. Immunol., June 1, 2005; 174(11): 7278 - 7284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Elm, R. Braathen, S. Bergmann, R. Frank, J.-P. Vaerman, C. S. Kaetzel, G. S. Chhatwal, F.-E. Johansen, and S. Hammerschmidt Ectodomains 3 and 4 of Human Polymeric Immunoglobulin Receptor (hpIgR) Mediate Invasion of Streptococcus pneumoniae into the Epithelium J. Biol. Chem., February 20, 2004; 279(8): 6296 - 6304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Jenkins, J. Wang, M. Vazir, J. Vela, O. Sahagun, P. Gabbay, L. Hoang, R. L. Diaz, R. Aranda, and M. G. Martin Role of passive and adaptive immunity in influencing enterocyte-specific gene expression Am J Physiol Gastrointest Liver Physiol, October 1, 2003; 285(4): G714 - G725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Schjerven, P. Brandtzaeg, and F.-E. Johansen Hepatocyte NF-1 and STAT6 Cooperate with Additional DNA-Binding Factors to Activate Transcription of the Human Polymeric Ig Receptor Gene in Response to IL-4 J. Immunol., June 15, 2003; 170(12): 6048 - 6056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ferkol, L. A. Cohn, T. E. Phillips, A. Smith, and P. B. Davis Targeted Delivery of Antiprotease to the Epithelial Surface of Human Tracheal Xenografts Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1374 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Hempen, K. M. Phillips, P. S. Conway, K. H. Sandoval, T. A. Schneeman, H.-J. Wu, and C. S. Kaetzel Transcriptional Regulation of the Human Polymeric Ig Receptor Gene: Analysis of Basal Promoter Elements J. Immunol., August 15, 2002; 169(4): 1912 - 1921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Schjerven, P. Brandtzaeg, and F.-E. Johansen A Novel NF-{kappa}B/Rel Site in Intron 1 Cooperates with Proximal Promoter Elements to Mediate TNF-{alpha}-Induced Transcription of the Human Polymeric Ig Receptor J. Immunol., December 1, 2001; 167(11): 6412 - 6420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Pilette, Y. Ouadrhiri, V. Godding, J-P. Vaerman, and Y. Sibille Lung mucosal immunity: immunoglobulin-A revisited Eur. Respir. J., September 1, 2001; 18(3): 571 - 588. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
