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CUTTING EDGE |
-Chain in IgE Synthesis1
*
Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan;
Clinical Research Center for Allergy, National Sagamihara Hospital, Sagamihara, Japan;
Department of Experimental Medicine, University of Wales, Swansea, United Kingdom;
§
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan;
¶
Department of Otolaryngology, Japanese Red Cross Society, Wakayama Medical Center, Wakayama, Japan;
||
Department of Pediatrics, Osaka College of Medicine, Takatsuki, Japan; and
#
Kyoto Preventive Medical Center, Kyoto, Japan
Two variants of the IL-4R 
-chain (IL-4R) gene have
been recently identified in association with different atopic
disorders. To clarify the etiological relationship between the two
variants, we analyzed responsiveness to IL-4 of transfectants with four
kinds of IL-4R carrying either Val or Ile at 50 and either Gln or
Arg at 551. The substitution of Ile for Val augmented STAT6 activation,
proliferation, and transcription activity of the I
promoter by IL-4,
whereas that of Arg for Gln did not change these IL-4 signals.
Arg551 was not associated with atopic asthma in the
Japanese population. CD23 expression and IgE synthesis by IL-4 were
augmented in Ile50-bearing PBMC, compared with those
bearing Val50. Taken together, substitution of
Arg551 does not enhance the IL-4 signal for generation of
germline transcript, whereas the substitution of Ile50
contributes to enhancement of IgE synthesis.
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