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-Chain Selectively Influences the Development of the Common Mucosal Immune System Independent IgA-Producing B-1 Cell in Mucosa-Associated Tissues1
*
Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; and
Department of Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Deletion of IL-5R
-chain (IL-5R-/-) selectively
influenced the mucosal IgA responses in vivo. While levels of IgA in
mucosal secretions were more reduced in IL-5R-/- mice
than in wild-type mice, the levels of IgA in serum were not changed.
The frequency of IgA-producing cells was reduced in mucosal effector
sites (e.g., intestinal lamina propria and nasal passage), but not in
inductive sites such as Payer’s patches and nasal-associated
lymphoreticular tissues in IL-5R-/- mice.
IgA-committed (surface IgA+; sIgA+) B-1 cells
mainly resided in mucosal effector tissues, while conventional
sIgA+ B (B-2) cells formed in mucosal inductive sites of
wild-type mice. In contrast, in the effector tissue of
IL-5R-/- mice, sIgA+ B-1 cells, but not
sIgA+ B-2 cells in the inductive site, were significantly
reduced. IL-5R was more expressed on sIgA+ B-1 cells
than was IL-6R, while both IL-5R and IL-6R were expressed on
sIgA+ B-2 cells in wild-type mice. sIgA+ B-1
cells produced high levels of IgA with rIL-5 rather than of rIL-6 in
vitro. Taken together, the findings suggest that the IL-5/IL-5R
signaling pathway is critically important for the development of common
mucosal immune system independent sIgA+ B-1 cell in mucosal
effector tissues in vivo.
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