HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by O’Neil, D. Articles by Chain, B. Search for Related Content PubMed PubMed Citation Articles by O’Neil, D. Articles by Chain, B.

IFN- Down-Regulates MHC Expression and Antigen Processing in a Human B Cell Line¹

Department of Immunology, Windeyer Institute of Medical Sciences, University College London Medical School, London, United Kingdom

IFN- is a crucial mediator in the induction of cell-mediated Th1-type responses but is predominantly a negative regulator of B cell differentiation and proliferation. This cytokine is therefore a key factor in determining Th1 vs Th2 differentiation. This study investigates the action of IFN- in modulation of HLA-DR expression and Ag presentation by EBV-transformed human B cell lines. In contrast to its action on the monocyte/macrophage, IFN- down-regulates surface MHC expression on these B cells, and this regulation is posttranscriptional. In parallel with MHC down-regulation, there is a reduced capability to process and present exogenous protein and peptide Ag to T cell hybridomas. IFN- does not change the rates of fluid phase endocytosis or exocytosis in this model system but correlates with an up-regulation of the lysosomal enzymes cathepsins B and D.

This article has been cited by other articles:

				M. Bruewer, M. Utech, A. I. Ivanov, A. M. Hopkins, C. A. Parkos, and A. Nusrat Interferon-{gamma} induces internalization of epithelial tight junction proteins via a macropinocytosis-like process FASEB J, June 1, 2005; 19(8): 923 - 933. [Abstract] [Full Text] [PDF]

				I. Okamoto, K. Kohno, T. Tanimoto, K. Iwaki, T. Ishihara, S. Akamatsu, H. Ikegami, and M. Kurimoto IL-18 Prevents the Development of Chronic Graft-Versus-Host Disease in Mice J. Immunol., June 1, 2000; 164(11): 6067 - 6074. [Abstract] [Full Text] [PDF]