| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ß T Cell Development in Mice Deficient in the Common Cytokine Receptor 
-Chain: The Requirement for Bcl-2 Differs Depending on the TCR/MHC Affinity
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
Mice lacking the common cytokine receptor 
-chain
(c) exhibit severely compromised T cell development,
with diminished Bcl-2 expression in mature (CD4+ or
CD8+) thymocytes and peripheral T cells. Enforced
expression of Bcl-2 in these mice partially rescued 
ß T cell
development but not 
T cell development. Transgenic expression of
the OVA-specific DO11.10 (DO10) TCR also could modestly increase
thymocyte numbers, and T cells expressing the transgenic TCR
(KJ1-26+ T cells) were found in the periphery.
Interestingly, the presence of KJ1-26+ T cells was
dependent on the MHC background and was seen in the moderate affinity
H-2d/d background but not in the higher affinity
H-2d/b background in c-deficient mice. In
contrast, KJ1-26+ T cells exist in the periphery in both
the H-2d/d and H-2d/b backgrounds in DO10
transgenic c wild-type mice. These results suggest that
the importance of c-dependent signals for T cell
development differs depending on the affinity of TCR for MHC. Moreover,
enforced expression of Bcl-2 had a much greater effect on the
development of c-deficient T cells expressing the DO10
TCR in the high affinity H-2d/b background than in the
H-2d/d background, suggesting that
c-dependent Bcl-2 expression influences T cell
development in a TCR/MHC-dependent manner.
This article has been cited by other articles:
|
|
 |
|
  S. Uehara, S. M. Hayes, L. Li, D. El-Khoury, M. Canelles, B. J. Fowlkes, and P. E. Love Premature Expression of Chemokine Receptor CCR9 Impairs T Cell Development J. Immunol., January 1, 2006; 176(1): 75 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Charo, S. E. Finkelstein, N. Grewal, N. P. Restifo, P. F. Robbins, and S. A. Rosenberg Bcl-2 Overexpression Enhances Tumor-Specific T-Cell Survival Cancer Res., March 1, 2005; 65(5): 2001 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Q. Li, Q. Jiang, A. R. Khaled, J. R. Keller, and S. K. Durum Interleukin-7 Inactivates the Pro-apoptotic Protein Bad Promoting T Cell Survival J. Biol. Chem., July 9, 2004; 279(28): 29160 - 29166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Lindemann, M. Benczik, and S. L. Gaffen Anti-apoptotic Signaling by the Interleukin-2 Receptor Reveals a Function for Cytoplasmic Tyrosine Residues within the Common gamma (gamma c) Receptor Subunit J. Biol. Chem., March 14, 2003; 278(12): 10239 - 10249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamada, N. Ishii, H. Asao, K. Murata, C. Kanazawa, H. Sasaki, and K. Sugamura Signal-Transducing Adaptor Molecules STAM1 and STAM2 Are Required for T-Cell Development and Survival Mol. Cell. Biol., December 15, 2002; 22(24): 8648 - 8658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Minagawa, H. Watanabe, C. Miyaji, K. Tomiyama, H. Shimura, A. Ito, M. Ito, J. Domen, I. L. Weissman, and K. Kawai Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor {beta}-Chain-Deficient Mice J. Immunol., October 15, 2002; 169(8): 4153 - 4160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-H. Xue, P. E. Kovanen, C. A. Pise-Masison, M. Berg, M. F. Radovich, J. N. Brady, and W. J. Leonard IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes PNAS, October 15, 2002; 99(21): 13759 - 13764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Davey, C. Kurts, J. F.A.P. Miller, P. Bouillet, A. Strasser, A. G. Brooks, F. R. Carbone, and W. R. Heath Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2-inhibitable Pathway Mediated by Bim J. Exp. Med., October 7, 2002; 196(7): 947 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-S. Wu, J.-M. Lee, Y.-G. Lai, J.-C. Hsu, C.-Y. Tsai, Y.-H. Lee, and N.-S. Liao Reduced Expression of Bcl-2 in CD8+ T Cells Deficient in the IL-15 Receptor {alpha}-Chain J. Immunol., January 15, 2002; 168(2): 705 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Suto, H. Nakajima, K. Ikeda, S. Kubo, T. Nakayama, M. Taniguchi, Y. Saito, and I. Iwamoto CD4+CD25+ T-cell development is regulated by at least 2 distinct mechanisms Blood, January 15, 2002; 99(2): 555 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-K. Ye, K. Maki, H.-C. Lee, A. Ito, K. Kawai, H. Suzuki, T. W. Mak, Y.-h. Chien, T. Honjo, and K. Ikuta Differential Roles of Cytokine Receptors in the Development of Epidermal {gamma}{delta} T Cells J. Immunol., August 15, 2001; 167(4): 1929 - 1934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-R. Rodewald, C. Waskow, and C. Haller Essential Requirement for c-kit and Common {gamma} Chain in Thymocyte Development Cannot be Overruled by Enforced Expression of Bcl-2 J. Exp. Med., June 18, 2001; 193(12): 1431 - 1438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Otsu, K. Sugamura, and F. Candotti Lack of dominant-negative effects of a truncated {gamma}c on retroviral-mediated gene correction of immunodeficient mice Blood, March 15, 2001; 97(6): 1618 - 1624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. O. Porter, P. Scibelli, and T. R. Malek Control of T Cell Development In Vivo by Subdomains Within the IL-7 Receptor {{alpha}}-Chain Cytoplasmic Tail J. Immunol., January 1, 2001; 166(1): 262 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Love, J. Lee, and E. W. Shores Critical Relationship Between TCR Signaling Potential and TCR Affinity During Thymocyte Selection J. Immunol., September 15, 2000; 165(6): 3080 - 3087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fujimoto, T. Naka, R. Nakagawa, Y. Kawazoe, Y. Morita, A. Tateishi, K. Okumura, M. Narazaki, and T. Kishimoto Defective Thymocyte Development and Perturbed Homeostasis of T cells in STAT-Induced STAT Inhibitor-1/Suppressors of Cytokine Signaling-1 Transgenic Mice J. Immunol., August 15, 2000; 165(4): 1799 - 1806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Suzuki, H. Nakajima, Y. Saito, T. Saito, W. J. Leonard, and I. Iwamoto Janus kinase 3 (Jak3) is essential for common cytokine receptor {gamma} chain ({gamma}c)-dependent signaling: comparative analysis of {gamma}c, Jak3, and {gamma}c and Jak3 double-deficient mice Int. Immunol., February 1, 2000; 12(2): 123 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Dai, A. Arakelov, M. Wagener, B. T. Konieczny, and F. G. Lakkis The Role of the Common Cytokine Receptor {gamma}-Chain in Regulating IL-2-Dependent, Activation-Induced CD8+ T Cell Death J. Immunol., September 15, 1999; 163(6): 3131 - 3137. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
