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*
Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital Campus, London, United Kingdom; and
Department Biologia Cellulare e dello Sviluppo, Universitá "La Sapienza," Rome, Italy
The functional significance of MHC class II expression by vascular
endothelial cells remains obscure. In this study the possibility that
Ag presentation by endothelial cells (EC) influences T cell
transmigration, facilitating the recruitment of Ag-specific T cells
into tissues, was investigated. The frequencies of T cells with
specificity for an HLA-DR alloantigen, or for the recall Ag tetanus
toxoid (TT), were measured in peripheral blood CD45RO+
(memory) CD4+ T cells before and after transmigration
through 
-IFN-treated EC monolayers. Frequencies of anti-DR17,
IL-2-secreting T cells were fourfold higher in the T cells that
transmigrated through a monolayer of DR17-expressing EC. Similar
increases were seen in TT-specific, DR7-restricted T cells that
transmigrated through TT-pulsed, DR7-expressing EC. To examine more
directly the effects of cognate recognition of Ag presented by EC, T
cell clones were used. For clones that proliferated in a
costimulation-independent manner to Ag presented by EC, cognate
recognition arrested transmigration. In contrast, Ag
presentation by EC to B7-dependent T cell clones, which do not
proliferate following cognate recognition of EC, enhanced the rate of
transendothelial migration. These data suggest that Ag presentation by
EC may serve to augment the recruitment of Ag-specific T cells into
tissues and that proliferation and transmigration are mutually
exclusive T cell responses.
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