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CUTTING EDGE |
*
Department of Veterinary and Animal Sciences, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003;
Ruprecht-Karls-University of Heidelberg, Institute of Immunology, Heidelberg, Germany;
Friedrich-Alexander-University of Erlangen/Nuremberg, Institute of Experimental Medicine, Erlangen, Germany; and
§
Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104
The Notch receptor protein was originally identified in Drosophila and is known to mediate cell to cell communication and influence cell fate decisions. Members of this family have been isolated from invertebrates as well as vertebrates. We isolated mouse Notch-1 in a yeast two-hybrid screen with Nur77, which is a protein that has been shown previously to be required for apoptosis in T cell lines. The data presented below indicate that Notch-1 expression provides significant protection to T cell lines from TCR-mediated apoptosis. These data demonstrate a new antiapoptotic role for Notch-1, providing evidence that, in addition to regulating cell fate decisions, Notch-1 can play a critical role in controlling levels of cell death in T cells.
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 M. J. Lundell, H.-K. Lee, E. Perez, and L. Chadwell The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of Drosophila Development, September 1, 2003; 130(17): 4109 - 4121. [Abstract] [Full Text] [PDF]
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E. Y. Huang, A. M. Gallegos, S. M. Richards, S. M. Lehar, and M. J. Bevan Surface Expression of Notch1 on Thymocytes: Correlation with the Double-Negative to Double-Positive Transition J. Immunol., September 1, 2003; 171(5): 2296 - 2304. [Abstract] [Full Text] [PDF]
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J. M. Lee, K.-H. Lee, M. Weidner, B. A. Osborne, and S. D. Hayward Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis PNAS, September 3, 2002; 99(18): 11878 - 11883. [Abstract] [Full Text] [PDF]
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 M. Dorsch, G. Zheng, D. Yowe, P. Rao, Y. Wang, Q. Shen, C. Murphy, X. Xiong, Q. Shi, J.-C. Gutierrez-Ramos, et al. Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease Blood, August 28, 2002; 100(6): 2046 - 2055. [Abstract] [Full Text] [PDF]
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B. J. Fowlkes and E. A. Robey A Reassessment of the Effect of Activated Notch1 on CD4 and CD8 T Cell Development J. Immunol., August 15, 2002; 169(4): 1817 - 1821. [Abstract] [Full Text] [PDF]
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S. Jeffries, D. J. Robbins, and A. J. Capobianco Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notchic-Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line Mol. Cell. Biol., June 1, 2002; 22(11): 3927 - 3941. [Abstract] [Full Text] [PDF]
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H. Han, K. Tanigaki, N. Yamamoto, K. Kuroda, M. Yoshimoto, T. Nakahata, K. Ikuta, and T. Honjo Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision Int. Immunol., June 1, 2002; 14(6): 637 - 645. [Abstract] [Full Text] [PDF]
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F. Jundt, I. Anagnostopoulos, R. Forster, S. Mathas, H. Stein, and B. Dorken Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma Blood, May 1, 2002; 99(9): 3398 - 3403. [Abstract] [Full Text] [PDF]
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 L. Espinosa, S. Santos, J. Ingles-Esteve, P. Munoz-Canoves, and A. Bigas p65-NF{kappa}B synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR J. Cell Sci., March 15, 2002; 115(6): 1295 - 1303. [Abstract] [Full Text] [PDF]
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S. Kawamata, C. Du, K. Li, and C. Lavau Notch1 Perturbation of Hemopoiesis Involves Non-Cell- Autonomous Modifications J. Immunol., February 15, 2002; 168(4): 1738 - 1745. [Abstract] [Full Text] [PDF]
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L. Walker, A. Carlson, H. T. Tan-Pertel, G. Weinmaster, and J. Gasson The Notch Receptor and Its Ligands Are Selectively Expressed During Hematopoietic Development in the Mouse Stem Cells, November 1, 2001; 19(6): 543 - 552. [Abstract] [Full Text]
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J. Dang, T. Inukai, H. Kurosawa, K. Goi, T. Inaba, N. T. Lenny, J. R. Downing, S. Stifani, and A. T. Look The E2A-HLF Oncoprotein Activates Groucho-Related Genes and Suppresses Runx1 Mol. Cell. Biol., September 1, 2001; 21(17): 5935 - 5945. [Abstract] [Full Text] [PDF]
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P. Doerfler, M. S. Shearman, and R. M. Perlmutter Presenilin-dependent gamma -secretase activity modulates thymocyte development PNAS, July 19, 2001; (2001) 161102498. [Abstract] [Full Text] [PDF]
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J. Wang, L. Shelly, L. Miele, R. Boykins, M. A. Norcross, and E. Guan Human Notch-1 Inhibits NF-{{kappa}}B Activity in the Nucleus Through a Direct Interaction Involving a Novel Domain J. Immunol., July 1, 2001; 167(1): 289 - 295. [Abstract] [Full Text] [PDF]
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H. Höfelmayr, L. J. Strobl, G. Marschall, G. W. Bornkamm, and U. Zimber-Strobl Activated Notch1 Can Transiently Substitute for EBNA2 in the Maintenance of Proliferation of LMP1-Expressing Immortalized B Cells J. Virol., March 1, 2001; 75(5): 2033 - 2040. [Abstract] [Full Text]
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D. Chang, P. Valdez, T. Ho, and E. Robey MHC Recognition in Thymic Development: Distinct, Parallel Pathways for Survival and Lineage Commitment J. Immunol., December 15, 2000; 165(12): 6710 - 6715. [Abstract] [Full Text] [PDF]
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H. T. Tan-Pertel, L. Walker, D. Browning, A. Miyamoto, G. Weinmaster, and J. C. Gasson Notch Signaling Enhances Survival and Alters Differentiation of 32D Myeloblasts J. Immunol., October 15, 2000; 165(8): 4428 - 4436. [Abstract] [Full Text] [PDF]
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 G. F. HOYNE, K. TAN, M. CORSIN-JIMENEZ, K. WAHL, M. STEWART, S. E. M. HOWIE, and J. R. LAMB Immunological Tolerance to Inhaled Antigen Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): S169 - 174. [Abstract] [Full Text] [PDF]
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B. J. Feldman, T. Hampton, and M. L. Cleary A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice Blood, September 1, 2000; 96(5): 1906 - 1913. [Abstract] [Full Text] [PDF]
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 T. P. Dang, A. F. Gazdar, A. K. Virmani, T. Sepetavec, K. R. Hande, J. D. Minna, J. R. Roberts, and D. P. Carbone Chromosome 19 Translocation, Overexpression of Notch3, and Human Lung Cancer J Natl Cancer Inst, August 16, 2000; 92(16): 1355 - 1357. [Full Text] [PDF]
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S. Tsai, J. Fero, and S. Bartelmez Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact Blood, August 1, 2000; 96(3): 950 - 957. [Abstract] [Full Text] [PDF]
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S. Jeffries and A. J. Capobianco Neoplastic Transformation by Notch Requires Nuclear Localization Mol. Cell. Biol., June 1, 2000; 20(11): 3928 - 3941. [Abstract] [Full Text]
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K. Ohishi, B. Varnum-Finney, D. Flowers, C. Anasetti, D. Myerson, and I. D. Bernstein Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1 Blood, May 1, 2000; 95(9): 2847 - 2854. [Abstract] [Full Text] [PDF]
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F. Radtke, I. Ferrero, A. Wilson, R. Lees, M. Aguet, and H. R. MacDonald Notch1 Deficiency Dissociates the Intrathymic Development of Dendritic Cells and T Cells J. Exp. Med., March 27, 2000; 191(7): 1085 - 1094. [Abstract] [Full Text] [PDF]
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M. D. Rand, L. M. Grimm, S. Artavanis-Tsakonas, V. Patriub, S. C. Blacklow, J. Sklar, and J. C. Aster Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors Mol. Cell. Biol., March 1, 2000; 20(5): 1825 - 1835. [Abstract] [Full Text]
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W. Han, Q. Ye, and M. A. S. Moore A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells Blood, March 1, 2000; 95(5): 1616 - 1625. [Abstract] [Full Text] [PDF]
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M. Rones, K. McLaughlin, M Raffin, and M Mercola Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis Development, January 9, 2000; 127(17): 3865 - 3876. [Abstract] [PDF]
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M. Kaneta, M. Osawa, M. Osawa, K. Sudo, H. Nakauchi, A. G. Farr, and Y. Takahama2 A Role for Pref-1 and HES-1 in Thymocyte Development J. Immunol., January 1, 2000; 164(1): 256 - 264. [Abstract] [Full Text] [PDF]
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 Y. Ye and M. E. Fortini Apoptotic Activities of Wild-type and Alzheimer's Disease-related Mutant Presenilins in Drosophila melanogaster J. Cell Biol., September 20, 1999; 146(6): 1351 - 1364. [Abstract] [Full Text] [PDF]
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 S. Artavanis-Tsakonas, M. D. Rand, and R. J. Lake Notch Signaling: Cell Fate Control and Signal Integration in Development Science, April 30, 1999; 284(5415): 770 - 776. [Abstract] [Full Text]
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T. Morimura, R. Goitsuka, Y. Zhang, I. Saito, M. Reth, and D. Kitamura Cell Cycle Arrest and Apoptosis Induced by Notch1 in B Cells J. Biol. Chem., November 17, 2000; 275(47): 36523 - 36531. [Abstract] [Full Text] [PDF]
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J. Ingles-Esteve, L. Espinosa, L. A. Milner, C. Caelles, and A. Bigas Phosphorylation of Ser2078 Modulates the Notch2 Function in 32D Cell Differentiation J. Biol. Chem., November 21, 2001; 276(48): 44873 - 44880. [Abstract] [Full Text] [PDF]
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P. Doerfler, M. S. Shearman, and R. M. Perlmutter Presenilin-dependent gamma -secretase activity modulates thymocyte development PNAS, July 31, 2001; 98(16): 9312 - 9317. [Abstract] [Full Text] [PDF]
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