| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
and IL-61
*
Department of Cellular Biology, Facultad de Biologia, Universidad Complutense, Madrid, Spain;
Department of Medical Biochemistry and Molecular Biology, Medical School, Sevilla, Spain; and
Department of Biological Sciences, Rutgers University, Newark, NJ 07102
The neuropeptides vasoactive intestinal peptide (VIP) and pituitary
adenylate cyclase-activating polypeptide (PACAP) down-regulate cytokine
production. Because human septic shock involves excessive cytokine
production, the effect of VIP/PACAP was investigated in a high
endotoxemia murine model. Both peptides protect against
endotoxin-induced lethality and prevent septic shock-associated
histopathological alterations. VIP/PACAP reduce serum and peritoneal
TNF-
and IL-6, suggesting that the protective effect is exerted by
inhibiting the production of endogenous TNF-/IL-6. Consistent with
this mechanism, VIP does not protect against septic shock induced by
exogenous TNF-. The immunomodulatory role of VIP in vivo is
supported by the appearance of high levels of VIP in serum and
peritoneal fluid following LPS administration. Thus, the neuropeptides
VIP/PACAP protect from the lethal effect of high endotoxemia,
presumably by down-regulating TNF- and IL-6 production, and may
offer an alternative in the treatment of human septic shock
syndrome.
This article has been cited by other articles:
|
|
 |
|
  A. Chorny and M. Delgado Neuropeptides Rescue Mice from Lethal Sepsis by Down-regulating Secretion of the Late-Acting Inflammatory Mediator High Mobility Group Box 1 Am. J. Pathol., May 1, 2008; 172(5): 1297 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Gonzalez-Rey, P. Anderson, and M. Delgado Emerging roles of vasoactive intestinal peptide: a new approach for autoimmune therapy Ann Rheum Dis, November 1, 2007; 66(suppl_3): iii70 - iii76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Foster, K. Andreadou, L. Jamieson, P.M. Preshaw, and J.J. Taylor VIP Inhibits P. gingivalis LPS-induced IL-18 and IL-18BPa in Monocytes J. Dent. Res., September 1, 2007; 86(9): 883 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Szliter, S. Lighvani, R. P. Barrett, and L. D. Hazlett Vasoactive Intestinal Peptide Balances Pro- and Anti-Inflammatory Cytokines in the Pseudomonas aeruginosa-Infected Cornea and Protects against Corneal Perforation J. Immunol., January 15, 2007; 178(2): 1105 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev, October 1, 2006; 86(4): 1309 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Gonzalez-Rey, A. Chorny, G. Robledo, and M. Delgado Cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia J. Exp. Med., March 20, 2006; 203(3): 563 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kim, B. D. Lee, O. Kim, Y.-S. Bae, T. Lee, P.-G. Suh, and S. H. Ryu Pituitary adenylate cyclase-activating polypeptide 27 is a functional ligand for formyl Peptide receptor-like 1. J. Immunol., March 1, 2006; 176(5): 2969 - 2975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Block, G. Li, L. Qin, X. Wu, Z. Pei, T. Wang, B. Wilson, J. Yang, and J. S. Hong Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin FASEB J, February 1, 2006; 20(2): 251 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Martinez, Y. Juarranz, C. Abad, A. Arranz, B. G. Miguel, F. Rosignoli, J. Leceta, and R. P. Gomariz Analysis of the role of the PAC1 receptor in neutrophil recruitment, acute-phase response, and nitric oxide production in septic shock J. Leukoc. Biol., May 1, 2005; 77(5): 729 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kato, A. Ito, J. Kawanokuchi, S. Jin, T. Mizuno, K. Ojika, R. Ueda, and A. Suzumura Pituitary adenylate cyclase-activating polypeptide (PACAP) ameliorates experimental autoimmune encephalomyelitis by suppressing the functions of antigen presenting cells Multiple Sclerosis, December 1, 2004; 10(6): 651 - 659. [Abstract] [PDF]
|
|
|
|
|
|
S. Kodali, W. Ding, J. Huang, K. Seiffert, J. A. Wagner, and R. D. Granstein Vasoactive Intestinal Peptide Modulates Langerhans Cell Immune Function J. Immunol., November 15, 2004; 173(10): 6082 - 6088. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Delgado, D. Pozo, and D. Ganea The Significance of Vasoactive Intestinal Peptide in Immunomodulation Pharmacol. Rev., June 1, 2004; 56(2): 249 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Juarranz, B. Santiago, M. Torroba, I. Gutierrez-Canas, G. Palao, M. Galindo, C. Abad, C. Martinez, J. Leceta, J. L. Pablos, et al. Vasoactive intestinal peptide modulates proinflammatory mediator synthesis in osteoarthritic and rheumatoid synovial cells Rheumatology, April 1, 2004; 43(4): 416 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Steinhoff, S. Stander, S. Seeliger, J. C. Ansel, M. Schmelz, and T. Luger Modern Aspects of Cutaneous Neurogenic Inflammation Arch Dermatol, November 1, 2003; 139(11): 1479 - 1488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Delgado Inhibition of Interferon (IFN) {gamma}-induced Jak-STAT1 Activation in Microglia by Vasoactive Intestinal Peptide: INHIBITORY EFFECT ON CD40, IFN-INDUCED PROTEIN-10, AND INDUCIBLE NITRIC-OXIDE SYNTHASE EXPRESSION J. Biol. Chem., July 18, 2003; 278(30): 27620 - 27629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delgado, J. Leceta, and D. Ganea Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the production of inflammatory mediators by activated microglia J. Leukoc. Biol., January 1, 2003; 73(1): 155 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Ganea and M. Delgado VASOACTIVE INTESTINAL PEPTIDE (VIP) AND PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AS MODULATORS OF BOTH INNATE AND ADAPTIVE IMMUNITY Crit. Rev. Oral. Biol. Med., May 1, 2002; 13(3): 229 - 237. [Abstract] [Full Text]
|
|
|
|
|
|
C. Abad, C. Martinez, J. Leceta, R. P. Gomariz, and M. Delgado Pituitary Adenylate Cyclase-Activating Polypeptide Inhibits Collagen-Induced Arthritis: An Experimental Immunomodulatory Therapy J. Immunol., September 15, 2001; 167(6): 3182 - 3189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delgado and D. Ganea Inhibition of Endotoxin-Induced Macrophage Chemokine Production by Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide In Vitro and In Vivo J. Immunol., July 15, 2001; 167(2): 966 - 975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delgado and D. Ganea Inhibition of IFN-{gamma}-Induced Janus Kinase-1-STAT1 Activation in Macrophages by Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide J. Immunol., September 15, 2000; 165(6): 3051 - 3057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Vaudry, B. J. Gonzalez, M. Basille, L. Yon, A. Fournier, and H. Vaudry Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions Pharmacol. Rev., June 1, 2000; 52(2): 269 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-K. Kim, Y. Kan, D. Ganea, R. P. Hart, I. Gozes, and G. M. Jonakait Vasoactive Intestinal Peptide and Pituitary Adenylyl Cyclase-Activating Polypeptide Inhibit Tumor Necrosis Factor-alpha Production in Injured Spinal Cord and in Activated Microglia via a cAMP-Dependent Pathway J. Neurosci., May 15, 2000; 20(10): 3622 - 3630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delgado and D. Ganea Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Interleukin-12 Transcription by Regulating Nuclear Factor kappa B and Ets Activation J. Biol. Chem., November 5, 1999; 274(45): 31930 - 31940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delgado, W. Sun, J. Leceta, and D. Ganea VIP and PACAP Differentially Regulate the Costimulatory Activity of Resting and Activated Macrophages Through the Modulation of B7.1 and B7.2 Expression J. Immunol., October 15, 1999; 163(8): 4213 - 4223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Delneste, N. Herbault, B. Galea, G. Magistrelli, I. Bazin, J.-Y. Bonnefoy, and P. Jeannin Vasoactive Intestinal Peptide Synergizes with TNF-{alpha} in Inducing Human Dendritic Cell Maturation J. Immunol., September 15, 1999; 163(6): 3071 - 3075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delgado, E. J. Munoz-Elias, R. P. Gomariz, and D. Ganea Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Prevent Inducible Nitric Oxide Synthase Transcription in Macrophages by Inhibiting NF-{kappa}B and IFN Regulatory Factor 1 Activation J. Immunol., April 15, 1999; 162(8): 4685 - 4696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Martinez, C. Abad, M. Delgado, A. Arranz, M. G. Juarranz, N. Rodriguez-Henche, P. Brabet, J. Leceta, and R. P. Gomariz Anti-inflammatory role in septic shock of pituitary adenylate cyclase-activating polypeptide receptor PNAS, January 22, 2002; 99(2): 1053 - 1058. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
