| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814;
Pulmonary Center and Department of Pathology, Boston University School of Medicine, Boston, MA 02118; and
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
Recent work has demonstrated that the transcription factor, IFN
consensus sequence binding protein (ICSBP), plays a critical role in
the capacity of mice to control infection with Toxoplasma
gondii and Leishmania major, agents that require
highly activated macrophages for their elimination. In this report the
regulation of ICSBP mRNA and protein were analyzed in murine
macrophages stimulated with LPS and/or IFN-
. Like induction of
leishmaniacidal activity, LPS and IFN- synergize to induce ICSBP
mRNA and protein. Deletion analysis of the ICSBP promoter identified
regions that were IFN- responsive, regions that mediate the ability
of LPS and IFN- to activate this promoter synergistically, as well
as regions that normally repress ICSBP transcription. Finally,
exogenous expression of ICSBP, found in previous studies to
down-regulate MHC I gene expression, failed to repress basal or
IFN--induced ICSBP transcription. This demonstrates that ICSBP can
selectively suppress the expression of IFN-responsive genes. These
findings extend in a significant way our understanding of the
regulation of ICSBP by LPS and IFN- and provide important clues as
to its role in macrophage activation.
This article has been cited by other articles:
|
|
 |
|
  A. la Sala, J. He, L. Laricchia-Robbio, S. Gorini, A. Iwasaki, M. Braun, G. S. Yap, A. Sher, K. Ozato, and B. Kelsall Cholera toxin inhibits IL-12 production and CD8{alpha}+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function J. Exp. Med., June 8, 2009; 206(6): 1227 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Koenigsmann, C. Rudolph, S. Sander, O. Kershaw, A. D. Gruber, L. Bullinger, B. Schlegelberger, and D. Carstanjen Nf1 haploinsufficiency and Icsbp deficiency synergize in the development of leukemias Blood, May 7, 2009; 113(19): 4690 - 4701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Kong, D. E. Anderson, C. H. Lee, M. K. Jang, T. Tamura, P. Tailor, H. K. Cho, J. Cheong, H. Xiong, H. C. Morse III, et al. Cutting Edge: Autoantigen Ro52 Is an Interferon Inducible E3 Ligase That Ubiquitinates IRF-8 and Enhances Cytokine Expression in Macrophages J. Immunol., July 1, 2007; 179(1): 26 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schroder, M. Lichtinger, K. M. Irvine, K. Brion, A. Trieu, I. L. Ross, T. Ravasi, K. J. Stacey, M. Rehli, D. A. Hume, et al. PU.1 and ICSBP control constitutive and IFN-{gamma}-regulated Tlr9 gene expression in mouse macrophages J. Leukoc. Biol., June 1, 2007; 81(6): 1577 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Yang, Y. Chu, Y. Wang, R. Zhang, and S. Xiong Targeted in vivo expression of IFN-{gamma}-inducible protein 10 induces specific antitumor activity J. Leukoc. Biol., December 1, 2006; 80(6): 1434 - 1444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhu, M. S. Chang, R. C. Hsueh, R. Taussig, K. D. Smith, M. I. Simon, and S. Choi Dual Ligand Stimulation of RAW 264.7 Cells Uncovers Feedback Mechanisms That Regulate TLR-Mediated Gene Expression J. Immunol., October 1, 2006; 177(7): 4299 - 4310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lehtonen, V. Veckman, T. Nikula, R. Lahesmaa, L. Kinnunen, S. Matikainen, and I. Julkunen Differential Expression of IFN Regulatory Factor 4 Gene in Human Monocyte-Derived Dendritic Cells and Macrophages J. Immunol., November 15, 2005; 175(10): 6570 - 6579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Xiong, H. Li, H. J. Kong, Y. Chen, J. Zhao, S. Xiong, B. Huang, H. Gu, L. Mayer, K. Ozato, et al. Ubiquitin-dependent Degradation of Interferon Regulatory Factor-8 Mediated by Cbl Down-regulates Interleukin-12 Expression J. Biol. Chem., June 24, 2005; 280(25): 23531 - 23539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhu, G. Saberwal, Y. Lu, L. C. Platanias, and E. A. Eklund The Interferon Consensus Sequence-binding Protein Activates Transcription of the Gene Encoding Neurofibromin 1 J. Biol. Chem., December 3, 2004; 279(49): 50874 - 50885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Alter-Koltunoff, S. Ehrlich, N. Dror, A. Azriel, M. Eilers, H. Hauser, H. Bowen, C. H. Barton, T. Tamura, K. Ozato, et al. Nramp1-mediated Innate Resistance to Intraphagosomal Pathogens Is Regulated by IRF-8, PU.1, and Miz-1 J. Biol. Chem., November 7, 2003; 278(45): 44025 - 44032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kuwata, C. Gongora, Y. Kanno, K. Sakaguchi, T. Tamura, T. Kanno, V. Basrur, R. Martinez, E. Appella, T. Golub, et al. Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element Mol. Cell. Biol., November 1, 2002; 22(21): 7439 - 7448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. S. Kim, E. J. Park, E.-h. Joe, and I. Jou JAK-STAT Signaling Mediates Gangliosides-induced Inflammatory Responses in Brain Microglial Cells J. Biol. Chem., October 18, 2002; 277(43): 40594 - 40601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tsujimura, T. Nagamura-Inoue, T. Tamura, and K. Ozato IFN Consensus Sequence Binding Protein/IFN Regulatory Factor-8 Guides Bone Marrow Progenitor Cells Toward the Macrophage Lineage J. Immunol., August 1, 2002; 169(3): 1261 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kallies, F. Rosenbauer, M. Scheller, K.-P. Knobeloch, and I. Horak Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages Blood, May 1, 2002; 99(9): 3213 - 3219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Doughty, K. B. Nguyen, J. E. Durbin, and C. A. Biron A Role for IFN-{{alpha}}{{beta}} in Virus Infection-Induced Sensitization to Endotoxin J. Immunol., February 15, 2001; 166(4): 2658 - 2664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Giroux and A. Descoteaux Cyclooxygenase-2 Expression in Macrophages: Modulation by Protein Kinase C-{alpha} J. Immunol., October 1, 2000; 165(7): 3985 - 3991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Cramer, S. L. Nelson, and M. J. Klemsz Synergistic Induction of the Tap-1 Gene by IFN-{gamma} and Lipopolysaccharide in Macrophages Is Regulated by STAT1 J. Immunol., September 15, 2000; 165(6): 3190 - 3197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-M. Kim, J. Y. Im, S. H. Han, H. S. Kang, and I. Choi IFN-{gamma} Up-Regulates IL-18 Gene Expression Via IFN Consensus Sequence-Binding Protein and Activator Protein-1 Elements in Macrophages J. Immunol., September 15, 2000; 165(6): 3198 - 3205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I-M. Wang, C. Contursi, A. Masumi, X. Ma, G. Trinchieri, and K. Ozato An IFN-{gamma}-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages J. Immunol., July 1, 2000; 165(1): 271 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hein, V. A. J. Kempf, J. Diebold, N. Bucheler, S. Preger, I. Horak, A. Sing, U. Kramer, and I. B. Autenrieth Interferon Consensus Sequence Binding Protein Confers Resistance against Yersinia enterocolitica Infect. Immun., March 1, 2000; 68(3): 1408 - 1417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Meraro, S. Hashmueli, B. Koren, A. Azriel, A. Oumard, S. Kirchhoff, H. Hauser, S. Nagulapalli, M. L. Atchison, and B.-Z. Levi Protein-Protein and DNA-Protein Interactions Affect the Activity of Lymphoid-Specific IFN Regulatory Factors J. Immunol., December 15, 1999; 163(12): 6468 - 6478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Marecki, M. L. Atchison, and M. J. Fenton Differential Expression and Distinct Functions of IFN Regulatory Factor 4 and IFN Consensus Sequence Binding Protein in Macrophages J. Immunol., September 1, 1999; 163(5): 2713 - 2722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Salkowski, K. Kopydlowski, J. Blanco, M. J. Cody, R. McNally, and S. N. Vogel IL-12 Is Dysregulated in Macrophages from IRF-1 and IRF-2 Knockout Mice J. Immunol., August 1, 1999; 163(3): 1529 - 1536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Cohen, A. Azriel, T. Cohen, D. Meraro, S. Hashmueli, D. Bech-Otschir, R. Kraft, W. Dubiel, and B.-Z. Levi Interaction between Interferon Consensus Sequence-binding Protein and COP9/Signalosome Subunit CSN2 (Trip15). A POSSIBLE LINK BETWEEN INTERFERON REGULATORY FACTOR SIGNALING AND THE COP9/SIGNALOSOME J. Biol. Chem., December 8, 2000; 275(50): 39081 - 39089. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
