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Departments of
*
Medical Microbiology and Immunology and
Pathology, University of Wisconsin Medical School, Madison, WI 53706; and
Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport, LA 71103
T cells have a crucial role in cell-mediated immunity (CMI)
against P. chabaudi malaria, but -chain knockout (KO)
(o/o) mice and mice depleted of T cells with mAb
cure this infection. To address the question of why mice deficient in
T cells resolve P. chabaudi infections, we
immunized o/o mice by infection with viable blood-stage
parasites. Sera from infection-immunized mice were tested for their
ability to protect JHo/o, o/o
double KO mice passively against P. chabaudi challenge
infection. The onset of parasitemia was significantly delayed in mice
receiving immune sera, compared with saline or uninfected serum
controls. Immune sera were then fractionated into Ig-rich and
Ig-depleted fractions by HPLC on a protein G column. Double KO mice
were passively immunized with either fraction and challenged with
P. chabaudi. The onset of parasitemia was significantly
delayed in recipients of the Ig-rich fraction compared with recipients
of the Ig-poor fraction of immune sera. We conclude that
o/o mice, which are unable to activate CMI against the
parasite, suppress P. chabaudi infection by a redundant
Ab-mediated process.
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H. C. van der Heyde, Y. Gu, Q. Zhang, G. Sun, and M. B. Grisham Nitric Oxide Is Neither Necessary Nor Sufficient for Resolution of Plasmodium chabaudi Malaria in Mice J. Immunol., September 15, 2000; 165(6): 3317 - 3323. [Abstract] [Full Text] [PDF]
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H. Xu, A. N. Hodder, H. Yan, P. E. Crewther, R. F. Anders, and M. F. Good CD4+ T Cells Acting Independently of Antibody Contribute to Protective Immunity to Plasmodium chabaudi Infection After Apical Membrane Antigen 1 Immunization J. Immunol., July 1, 2000; 165(1): 389 - 396. [Abstract] [Full Text] [PDF]
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