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Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama, Birmingham, AL 35294
Ag encounter will recruit Ag-specific cells from the pool of mature B lymphocytes in the spleen and activate them to perform effector functions: generation of Ab-forming cells (plasma cells) and presentation of Ag to T cells. We have compared the ability of mature follicular and marginal zone cells to develop into effector B cells. The generation of marginal zone B cells and their localization in the marginal sinus area are T cell and CD40 ligand independent, suggesting that they do not represent a postgerminal center population. Compared with mature recirculating follicular B cells, they express several characteristics of previous antigenic experience, including higher levels of B7.1 (CD80) and B7.2 (CD86) when freshly isolated and following in vitro stimulation. After a brief 6- to 8-h in vitro stimulation with LPS or anti-CD40 Abs, marginal zone B cells become potent APCs. In addition, their ability to proliferate and differentiate into plasma cells in response to low doses of T-independent polyclonal stimuli (LPS) is far greater than that of follicular B cells. These findings indicate a functional heterogeneity within splenic mature B lymphocytes, with marginal zone B cells having the capacity to generate effector cells in early stages of the immune response against particulate Ags scavenged efficiently in this special anatomical site.
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D. C. Otero, A. N. Anzelon, and R. C. Rickert CD19 Function in Early and Late B Cell Development: I. Maintenance of Follicular and Marginal Zone B Cells Requires CD19-Dependent Survival Signals J. Immunol., January 1, 2003; 170(1): 73 - 83. [Abstract] [Full Text] [PDF]
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T. Samardzic, D. Marinkovic, P. J. Nielsen, L. Nitschke, and T. Wirth BOB.1/OBF.1 Deficiency Affects Marginal-Zone B-Cell Compartment Mol. Cell. Biol., December 1, 2002; 22(23): 8320 - 8331. [Abstract] [Full Text] [PDF]
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S. Julien, P. Soulas, J.-C. Garaud, T. Martin, and J.-L. Pasquali B Cell Positive Selection by Soluble Self-Antigen J. Immunol., October 15, 2002; 169(8): 4198 - 4204. [Abstract] [Full Text] [PDF]
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Z.-Q. Wu, Y. Shen, A. Q. Khan, C.-L. Chu, R. Riese, H. A. Chapman, O. Kanagawa, and C. M. Snapper The Mechanism Underlying T Cell Help for Induction of an Antigen-Specific In Vivo Humoral Immune Response to Intact Streptococcus pneumoniae Is Dependent on the Type of Antigen J. Immunol., June 1, 2002; 168(11): 5551 - 5557. [Abstract] [Full Text] [PDF]
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W.-J. Won and J. F. Kearney CD9 Is a Unique Marker for Marginal Zone B Cells, B1 Cells, and Plasma Cells in Mice J. Immunol., June 1, 2002; 168(11): 5605 - 5611. [Abstract] [Full Text] [PDF]
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S. Itoh, M. Itoh, K. Nishida, S. Yamasaki, Y. Yoshida, M. Narimatsu, S. J. Park, M. Hibi, K. Ishihara, and T. Hirano Adapter Molecule Grb2-Associated Binder 1 Is Specifically Expressed in Marginal Zone B Cells and Negatively Regulates Thymus-Independent Antigen-2 Responses J. Immunol., May 15, 2002; 168(10): 5110 - 5116. [Abstract] [Full Text] [PDF]
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 H Schuster, T Martin, L Marcellin, J-C Garaud, J-L Pasquali, and A S Korganow Expansion of marginal zone B cells is not sufficient for the development of renal disease in NZBxNZW F1 mice Lupus, May 1, 2002; 11(5): 277 - 286. [Abstract] [PDF]
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T. L. Carvalho, T. Mota-Santos, A. Cumano, J. Demengeot, and P. Vieira Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7-/- Mice J. Exp. Med., October 15, 2001; 194(8): 1141 - 1150. [Abstract] [Full Text] [PDF]
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Z. Hao and K. Rajewsky Homeostasis of Peripheral B Cells in the Absence of B Cell Influx from the Bone Marrow J. Exp. Med., October 15, 2001; 194(8): 1151 - 1164. [Abstract] [Full Text] [PDF]
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X. Li, F. Martin, A. M. Oliver, J. F. Kearney, and R. H. Carter Antigen Receptor Proximal Signaling in Splenic B-2 Cell Subsets J. Immunol., March 1, 2001; 166(5): 3122 - 3129. [Abstract] [Full Text] [PDF]
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S. R. Dillon, A. Constantinescu, and M. S. Schlissel Annexin V Binds to Positively Selected B Cells J. Immunol., January 1, 2001; 166(1): 58 - 71. [Abstract] [Full Text] [PDF]
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P. M. Dammers, A. Visser, E. R. Popa, P. Nieuwenhuis, and F. G. M. Kroese Most Marginal Zone B Cells in Rat Express Germline Encoded Ig VH Genes and Are Ligand Selected J. Immunol., December 1, 2000; 165(11): 6156 - 6169. [Abstract] [Full Text] [PDF]
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A. Cariappa, H.-C. Liou, B. H. Horwitz, and S. Pillai Nuclear Factor {kappa}b Is Required for the Development of Marginal Zone B Lymphocytes J. Exp. Med., October 16, 2000; 192(8): 1175 - 1182. [Abstract] [Full Text] [PDF]
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P. Sanchez, A.-M. Crain-Denoyelle, P. Daras, M.-C. Gendron, and C. Kanellopoulos-Langevin The level of expression of {micro} heavy chain modifies the composition of peripheral B cell subpopulations Int. Immunol., October 1, 2000; 12(10): 1459 - 1466. [Abstract] [Full Text] [PDF]
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H. Ogata, I-h. Su, K. Miyake, Y. Nagai, S. Akashi, I. Mecklenbrauker, K. Rajewsky, M. Kimoto, and A. Tarakhovsky The Toll-like Receptor Protein Rp105 Regulates Lipopolysaccharide Signaling in B Cells J. Exp. Med., July 3, 2000; 192(1): 23 - 30. [Abstract] [Full Text] [PDF]
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