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The Journal of Immunology, 1999, 162: 6955-6958.
Copyright © 1999 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Anti-CD1 Monoclonal Antibody Treatment Reverses the Production Patterns of TGF-ß2 and Th1 Cytokines and Ameliorates Listeriosis in Mice1

Gudrun Szalay*,{dagger}, Christoph H. Ladel2,{dagger}, Carmen Blum{dagger}, Laurent Brossay{ddagger}, Mitchell Kronenberg{ddagger} and Stefan H. E. Kaufmann3,*,{dagger}

* Max Planck Institute for Infection Biology, Berlin, Germany; {dagger} Department of Immunology, University Clinics, Ulm, Germany; and {ddagger} La Jolla Institute for Allergy and Immunology, San Diego, CA 92121

Protection against intracellular bacteria by T cells is regulated by Ag-presenting molecules, which comprise classical MHC class I molecules, MHC class II molecules, and nonclassical MHC class Ib molecules. The role of CD1 molecules, which are structurally similar to classical MHC class I gene products, but less polymorphic, is not understood so far. We show that CD1 surface expression increased on APC in Listeria-infected mice. The in vivo treatment with anti-CD1 mAb reduced TGF-ß2 levels and concomitantly increased secretion of the proinflammatory cytokine TNF, the Th1 cell promoting cytokine IL-12, and the Th1 cell cytokine IFN-{gamma} at the onset of listerial infection. These findings point to a regulatory role of CD1-reactive cells in the immune response against listeriosis.




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