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*
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA 02115; and
Department of Medicine, Division of Immunology, and
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115
NK cells are believed to play a critical role in the development of
immunity against Leishmania major. We recently found
that transplantation of wild-type bone marrow cells into neonatal tg
26 mice, which are deficient in T and NK cells, resulted in normal T
cell development, but no or poor NK cell development. Using this novel
model we analyzed the role of NK cells in the development of Th1
response and control of cutaneous L. major infection.
Mice selectively lacking NK cells (NK-T+)
developed an efficient Th1-like response, produced significant amounts
of IL-12 and IFN-
, and controlled cutaneous L. major
infection. Administration of neutralizing IL-12 Abs to
NK-T+ mice during L. major
infection resulted in exacerbation of the disease. These results
demonstrate that NK cells are not critical for development of
protective immunity against L. major. Furthermore, they
indicate that IL-12 can induce development of Th1 response independent
of NK cells in NK-T+ mice following
L.major infection.
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