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E (CD103)-Deficient Mice1
*
Division of Rheumatology, Immunology, and Allergy, and
Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115;
Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115; and
§
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030
The mucosal lymphocyte integrin
E(CD103)ß7 is thought to be important for
intraepithelial lymphocyte (IEL) localization or function. We cloned
the murine integrin gene encoding E, localized it to
chromosome 11, and generated integrin E-deficient mice.
In E-/- mice, intestinal and vaginal IEL
numbers were reduced, consistent with the known binding of
Eß7 to E-cadherin expressed on epithelial
cells. However, it was surprising that lamina propria T lymphocyte
numbers were diminished, as E-cadherin is not expressed in the lamina
propria. In contrast, peribronchial, intrapulmonary, Peyer’s patch,
and splenic T lymphocyte numbers were not reduced in
E-deficient mice. Thus, Eß7
was important for generating or maintaining the gut and vaginal T
lymphocytes located diffusely within the epithelium or lamina propria
but not for generating the gut-associated organized lymphoid tissues.
Finally, the impact of E deficiency upon intestinal IEL
numbers was greater at 3–4 wk of life than in younger animals, and
affected the TCR ß+ CD8+ T cells more than
the 
T cells or the TCR ß+
CD4+CD8- population. These findings suggest
that Eß7 is involved in the
expansion/recruitment of TCR ß+ CD8+ IEL
following microbial colonization. Integrin E-deficient
mice will provide an important tool for studying the role of
Eß7 and of
Eß7-expressing mucosal T lymphocytes in
vivo.
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A. G. Arroyo, D. Taverna, C. A. Whittaker, U. G. Strauch, B. L. Bader, H. Rayburn, D. Crowley, C. M. Parker, and R. O. Hynes In Vivo Roles of Integrins During Leukocyte Development and Traffic: Insights from the Analysis of Mice Chimeric for {alpha}5, {alpha}v, and {alpha}4 Integrins J. Immunol., October 15, 2000; 165(8): 4667 - 4675. [Abstract] [Full Text] [PDF]
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K. S. Taraszka, J. M.G. Higgins, K. Tan, D. A. Mandelbrot, J.-h. Wang, and M. B. Brenner Molecular Basis for Leukocyte Integrin {alpha}E{beta}7 Adhesion to Epithelial (E)-Cadherin J. Exp. Med., May 1, 2000; 191(9): 1555 - 1567. [Abstract] [Full Text] [PDF]
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 D. J. Erle and R. Pabst Intraepithelial Lymphocytes in the Lung . A Neglected Lymphocyte Population Am. J. Respir. Cell Mol. Biol., April 1, 2000; 22(4): 398 - 400. [Full Text]
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T. Oida, K. Suzuki, M. Nanno, Y. Kanamori, H. Saito, E. Kubota, S. Kato, M. Itoh, S. Kaminogawa, and H. Ishikawa Role of Gut Cryptopatches in Early Extrathymic Maturation of Intestinal Intraepithelial T Cells J. Immunol., April 1, 2000; 164(7): 3616 - 3626. [Abstract] [Full Text] [PDF]
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A. Muehlhoefer, L. J. Saubermann, X. Gu, K. Luedtke-Heckenkamp, R. Xavier, R. S. Blumberg, D. K. Podolsky, R. P. MacDermott, and H.-C. Reinecker Fractalkine Is an Epithelial and Endothelial Cell-Derived Chemoattractant for Intraepithelial Lymphocytes in the Small Intestinal Mucosa J. Immunol., March 15, 2000; 164(6): 3368 - 3376. [Abstract] [Full Text] [PDF]
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E. Corps, C. Carter, P. Karecla, T. Ahrens, P. Evans, and P. Kilshaw Recognition of E-cadherin by Integrin alpha Ebeta 7. REQUIREMENT FOR CADHERIN DIMERIZATION AND IMPLICATIONS FOR CADHERIN AND INTEGRIN FUNCTION J. Biol. Chem., August 10, 2001; 276(33): 30862 - 30870. [Abstract] [Full Text] [PDF]
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