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,§
*
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland;
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115;
CREST (Core Research for Evolutional Science and Technology) and Department of Molecular Immunology, Chiba University Graduate School of Medicine, Chiba, Japan; and
§
Department of Medicine, Harvard Medical School, Boston, MA 02115
NKT cells, defined as T cells expressing the NK cell marker NK1.1, are involved in tumor rejection and regulation of autoimmunity via the production of cytokines. We show in this study that two types of NKT cells can be defined on the basis of their reactivity to the monomorphic MHC class I-like molecule CD1d. One type of NKT cell is positively selected by CD1d and expresses a biased TCR repertoire together with a phenotype found on activated T cells. A second type of NKT cell, in contrast, develops in the absence of CD1d, and expresses a diverse TCR repertoire and a phenotype found on naive T cells and NK cells. Importantly, the two types of NKT cells segregate in distinct tissues. Whereas thymus and liver contain primarily CD1d-dependent NKT cells, spleen and bone marrow are enriched in CD1d-independent NKT cells. Collectively, our data suggest that recognition of tissue-specific ligands by the TCR controls localization and activation of NKT cells.
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L. Sfondrini, D. Besusso, M. T. Zoia, M. Rodolfo, A. M. Invernizzi, M. Taniguchi, T. Nakayama, M. P. Colombo, S. Menard, and A. Balsari Absence of the CD1 Molecule Up-Regulates Antitumor Activity Induced by CpG Oligodeoxynucleotides in Mice J. Immunol., July 1, 2002; 169(1): 151 - 158. [Abstract] [Full Text] [PDF]
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C. H. Kim, B. Johnston, and E. C. Butcher Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among Valpha 24+Vbeta 11+ NKT cell subsets with distinct cytokine-producing capacity Blood, June 17, 2002; 100(1): 11 - 16. [Abstract] [Full Text] [PDF]
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S. SHARIF, G. A. ARREAZA, P. ZUCKER, and T. L. DELOVITCH Regulatory Natural Killer T Cells Protect against Spontaneous and Recurrent Type 1 Diabetes Ann. N.Y. Acad. Sci., April 1, 2002; 958(1): 77 - 88. [Abstract] [Full Text] [PDF]
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V. Laloux, L. Beaudoin, C. Ronet, and A. Lehuen Phenotypic and Functional Differences Between NKT Cells Colonizing Splanchnic and Peripheral Lymph Nodes J. Immunol., April 1, 2002; 168(7): 3251 - 3258. [Abstract] [Full Text] [PDF]
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M. A. Exley, Q. He, O. Cheng, R.-J. Wang, C. P. Cheney, S. P. Balk, and M. J. Koziel Cutting Edge: Compartmentalization of Th1-Like Noninvariant CD1d-Reactive T Cells in Hepatitis C Virus-Infected Liver J. Immunol., February 15, 2002; 168(4): 1519 - 1523. [Abstract] [Full Text] [PDF]
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D. Zeng, P. Hoffmann, F. Lan, P. Huie, J. Higgins, and S. Strober Unique patterns of surface receptors, cytokine secretion, and immune functions distinguish T cells in the bone marrow from those in the periphery: impact on allogeneic bone marrow transplantation Blood, February 15, 2002; 99(4): 1449 - 1457. [Abstract] [Full Text] [PDF]
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J. A. Hobbs, S. Cho, T. J. Roberts, V. Sriram, J. Zhang, M. Xu, and R. R. Brutkiewicz Selective Loss of Natural Killer T Cells by Apoptosis following Infection with Lymphocytic Choriomeningitis Virus J. Virol., November 15, 2001; 75(22): 10746 - 10754. [Abstract] [Full Text] [PDF]
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M. A. Exley, S. M. A. Tahir, O. Cheng, A. Shaulov, R. Joyce, D. Avigan, R. Sackstein, and S. P. Balk Cutting Edge: A Major Fraction of Human Bone Marrow Lymphocytes Are Th2-Like CD1d-Reactive T Cells That Can Suppress Mixed Lymphocyte Responses J. Immunol., November 15, 2001; 167(10): 5531 - 5534. [Abstract] [Full Text] [PDF]
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Y. Ikarashi, R. Mikami, A. Bendelac, M. Terme, N. Chaput, M. Terada, T. Tursz, E. Angevin, F. A. Lemonnier, H. Wakasugi, et al. Dendritic Cell Maturation Overrules H-2D-mediated Natural Killer T (NKT) Cell Inhibition: Critical Role for B7 in CD1d-dependent NKT Cell Interferon {gamma} Production J. Exp. Med., October 15, 2001; 194(8): 1179 - 1186. [Abstract] [Full Text] [PDF]
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J. L. Matsuda, L. Gapin, N. Fazilleau, K. Warren, O. V. Naidenko, and M. Kronenberg Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size PNAS, October 5, 2001; (2001) 221445298. [Abstract] [Full Text] [PDF]
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C. Karnbach, M. R. Daws, E. C. Niemi, and M. C. Nakamura Immune Rejection of a Large Sarcoma Following Cyclophosphamide and IL-12 Treatment Requires Both NK and NK T Cells and Is Associated with the Induction of a Novel NK T Cell Population J. Immunol., September 1, 2001; 167(5): 2569 - 2576. [Abstract] [Full Text] [PDF]
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F. Lan, D. Zeng, M. Higuchi, P. Huie, J. P. Higgins, and S. Strober Predominance of NK1.1+TCR{alpha}{beta}+ or DX5+TCR{alpha}{beta}+ T Cells in Mice Conditioned with Fractionated Lymphoid Irradiation Protects Against Graft-Versus-Host Disease: "Natural Suppressor" Cells J. Immunol., August 15, 2001; 167(4): 2087 - 2096. [Abstract] [Full Text] [PDF]
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B. Wang, Y.-B. Geng, and C.-R. Wang CD1-restricted NK T Cells Protect Nonobese Diabetic Mice from Developing Diabetes J. Exp. Med., August 6, 2001; 194(3): 313 - 320. [Abstract] [Full Text] [PDF]
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N. Baur, G. Nerz, A. Nil, and K. Eichmann Expression and selection of productively rearranged TCR{beta} VDJ genes are sequentially regulated by CD3 signaling in the development of NK1.1+ {alpha}{beta} T cells Int. Immunol., August 1, 2001; 13(8): 1031 - 1042. [Abstract] [Full Text] [PDF]
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K. J. L. Hammond, D. G. Pellicci, L. D. Poulton, O. V. Naidenko, A. A. Scalzo, A. G. Baxter, and D. I. Godfrey CD1d-Restricted NKT Cells: An Interstrain Comparison J. Immunol., August 1, 2001; 167(3): 1164 - 1173. [Abstract] [Full Text] [PDF]
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J. Baker, M. R. Verneris, M. Ito, J. A. Shizuru, and R. S. Negrin Expansion of cytolytic CD8+ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon {gamma} production Blood, May 15, 2001; 97(10): 2923 - 2931. [Abstract] [Full Text] [PDF]
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M. A. Exley, N. J. Bigley, O. Cheng, S. M. A. Tahir, S. T. Smiley, Q. L. Carter, H. F. Stills, M. J. Grusby, Y. Koezuka, M. Taniguchi, et al. CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus J. Leukoc. Biol., May 1, 2001; 69(5): 713 - 718. [Abstract] [Full Text]
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N. L. O'Sullivan, C. A. Skandera, and P. C. Montgomery Lymphocyte Lineages at Mucosal Effector Sites: Rat Salivary Glands J. Immunol., May 1, 2001; 166(9): 5522 - 5529. [Abstract] [Full Text] [PDF]
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S.-H. Park, A. Weiss, K. Benlagha, T. Kyin, L. Teyton, and A. Bendelac The Mouse CD1d-restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families J. Exp. Med., April 9, 2001; 193(8): 893 - 904. [Abstract] [Full Text] [PDF]
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R. B. Fritz and M.-L. Zhao Regulation of Experimental Autoimmune Encephalomyelitis in the C57BL/6J Mouse by NK1.1+, DX5+, {{alpha}}{{beta}}+ T Cells J. Immunol., March 15, 2001; 166(6): 4209 - 4215. [Abstract] [Full Text] [PDF]
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C. Ronet, M. Mempel, N. Thieblemont, A. Lehuen, P. Kourilsky, and G. Gachelin Role of the Complementarity-Determining Region 3 (CDR3) of the TCR-{{beta}} Chains Associated with the V{{alpha}}14 Semi-Invariant TCR {{alpha}}-Chain in the Selection of CD4+ NK T Cells J. Immunol., February 1, 2001; 166(3): 1755 - 1762. [Abstract] [Full Text] [PDF] < |
