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*
Laboratory of Immunology, Istituto Dermopatico dell’Immacolata, IRCCS, Rome, Italy; and
Institute of Molecular Genetics, Academy of Science of the Czech Republic, Prague, Czech Republic
CD43/leukosialin is a major sialoglycoprotein of the dendritic cell
(DC) surface, which can regulate cell adhesion and has the potential to
mediate cell activation signals. Monocyte-derived DC transiently
incubated with the anti-CD43 mAb, MEM-59, or with
F(ab')2 fragments, but not with monovalent Fab fragments or
control IgG, 24 h later showed increased levels of membrane
HLA-DR, CD54, CD40, CD80, CD86, and CD83. In parallel, CD43
cross-linking induced synthesis and release of IL-1ß, IL-6, TNF-
,
IL-12, and IL-10. CD43 ligation inhibited the endocytic activity of DC,
and enhanced the capacity of DC to stimulate T cell proliferation in
the primary allogeneic and autologous MLR assay. In addition,
anti-CD43-treated DC were less efficient at presenting native HIV-1
reverse transcriptase to a specific CD4+ T cell clone,
whereas presentation of the reverse transcriptase 55–72 peptide to the
same clone was increased. Finally, MEM-59 or its F(ab')2
fragments elicited a rise in intracellular free calcium and tyrosine
phosphorylation of a 25-kDa protein in DC. The results thus indicate
that CD43 cross-linking with specific ligands induces activation and
functional maturation of DC.
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