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The Journal of Immunology, 1999, 162: 6312-6315.
Copyright © 1999 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Apoptosis of Superantigen-Activated T Cells Occurs Preferentially After a Discrete Number of Cell Divisions In Vivo1

Toufic Renno, Antoine Attinger, Sabrina Locatelli, Talitha Bakker, Sonia Vacheron and H. Robson MacDonald2

Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland

Staphylococcal enterotoxins are bacterial products that display superantigen activity in vitro as well as in vivo. For instance, staphylococcal enterotoxin B (SEB) polyclonally activates T cells that bear the Vß8 gene segment of the TCR. SEB-activated T cells undergo a burst of proliferation that is followed by apoptosis. Using an in vivo adaptation of a fluorescent cell division monitoring technique, we show here that SEB-activated T cells divide asynchronously, and that apoptosis of superantigen-activated T cells is preferentially restricted to cells which have undergone a discrete number of cell divisions. Collectively, our data suggest that superantigen-activated T cells are programmed to undergo a fixed number of cell divisions before undergoing apoptosis. A delayed death program may provide a mechanistic compromise between effector functions and homeostasis of activated T cells.




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