| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Parasitology and Immunology, Yamanashi Medical University, Tamaho-cho, Yamanashi, Japan
When mast cells are activated through their high affinity IgE
receptors (Fc
RI), release of chemical mediators is followed by
secretion of multiple cytokines. In this work, we report that
IL-3-dependent mast cell line MC9 undergoes apoptosis when IL-3 is
withdrawn. However, cross-linking of FcRI prevents apoptosis of MC9
by an autocrine mechanism, producing IL-3, IL-4, and GM-CSF. Although
stimulated MC9 synthesizes mRNAs and proteins of these cytokines,
secretion of endogenous IL-3 and GM-CSF is not enough for cell
survival, whereas IL-4 itself does not have survival effect on MC9, but
it induces cell aggregation by expressing LFA-1 and makes it reactive
to endogenous growth factors. Addition of dexamethazone (DXM) to MC9
results in significant down-regulation of IL-4 mRNA in activated MC9.
However, mRNA levels of IL-3 and GM-CSF are not changed by DXM. DXM
also directly down-regulates the expression of ICAM-1 that is the high
affinity ligand of LFA-1, by which the self-aggregation of MC9 is
inhibited. Thus, glucocorticoids suppress autocrine survival of mast
cells by inhibiting IL-4 production and ICAM-1
expression.
This article has been cited by other articles:
|
|
 |
|
  E. Ulleras, M. Karlberg, C. Moller Westerberg, J. Alfredsson, S. Gerondakis, A. Strasser, and G. Nilsson NFAT but not NF-{kappa}B is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells Blood, March 15, 2008; 111(6): 3081 - 3089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ekoff, T. Kaufmann, M. Engstrom, N. Motoyama, A. Villunger, J.-I. Jonsson, A. Strasser, and G. Nilsson The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells Blood, November 1, 2007; 110(9): 3209 - 3217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ekoff, A. Strasser, and G. Nilsson Fc{epsilon}RI Aggregation Promotes Survival of Connective Tissue-Like Mast Cells but Not Mucosal-Like Mast Cells J. Immunol., April 1, 2007; 178(7): 4177 - 4183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Berent-Maoz, A. M. Piliponsky, I. Daigle, H.-U. Simon, and F. Levi-Schaffer Human Mast Cells Undergo TRAIL-Induced Apoptosis J. Immunol., February 15, 2006; 176(4): 2272 - 2278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oki, J. Kitaura, K. Eto, Y. Lu, M. Maeda-Yamamoto, N. Inagaki, H. Nagai, Y. Yamanishi, H. Nakajina, H. Kumagai, et al. Integrin {alpha}IIb{beta}3 Induces the Adhesion and Activation of Mast Cells through Interaction with Fibrinogen J. Immunol., January 1, 2006; 176(1): 52 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kawakami and J. Kitaura Mast Cell Survival and Activation by IgE in the Absence of Antigen: A Consideration of the Biologic Mechanisms and Relevance J. Immunol., October 1, 2005; 175(7): 4167 - 4173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Xiang, A. A. Ahmed, C. Moller, K.-i. Nakayama, S. Hatakeyama, and G. Nilsson Essential Role of the Prosurvival bcl-2 Homologue A1 in Mast Cell Survival After Allergic Activation J. Exp. Med., November 26, 2001; 194(11): 1561 - 1570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chaves-Dias, T. R. Hundley, A. M. Gilfillan, A. S. Kirshenbaum, J. R. Cunha-Melo, D. D. Metcalfe, and M. A. Beaven Induction of Telomerase Activity During Development of Human Mast Cells from Peripheral Blood CD34+ Cells: Comparisons with Tumor Mast-Cell Lines J. Immunol., June 1, 2001; 166(11): 6647 - 6656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Castagliuolo, K. Karalis, L. Valenick, A. Pasha, S. Nikulasson, M. Wlk, and C. Pothoulakis Endogenous corticosteroids modulate Clostridium difficile toxin A-induced enteritis in rats Am J Physiol Gastrointest Liver Physiol, April 1, 2001; 280(4): G539 - G545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yoshikawa, Y. Nakajima, and K. Tasaka Enhanced Expression of Fas-Associated Death Domain-Like IL-1-Converting Enzyme (FLICE)-Inhibitory Protein Induces Resistance to Fas-Mediated Apoptosis in Activated Mast Cells J. Immunol., December 1, 2000; 165(11): 6262 - 6269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Egerer, E Feist, U Rohr, A Pruss, G-R Burmester, and T Dorner Increased serum soluble CD14, ICAM-1 and E-selectin correlate with disease activity and prognosis in systemic lupus erythematosus Lupus, October 1, 2000; 9(8): 614 - 621. [Abstract] [PDF]
|
|
|
|
|
|
R. Chen, T. F. Burke, J. E. Cumberland, M. Brummet, L. A. Beck, V. Casolaro, and S. N. Georas Glucocorticoids Inhibit Calcium- and Calcineurin-Dependent Activation of the Human IL-4 Promoter J. Immunol., January 15, 2000; 164(2): 825 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Masuda, T. Matsuguchi, K. Yamaki, T. Hayakawa, M. Kubo, W. J. LaRochelle, and Y. Yoshikai Interleukin-15 Induces Rapid Tyrosine Phosphorylation of STAT6 and the Expression of Interleukin-4 in Mouse Mast Cells J. Biol. Chem., September 15, 2000; 275(38): 29331 - 29337. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
