The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Noben-Trauth, N.
Right arrow Articles by Sacks, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Noben-Trauth, N.
Right arrow Articles by Sacks, D. L.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH
Medline Plus Health Information
*Leishmaniasis
The Journal of Immunology, 1999, 162: 6132-6140.
Copyright © 1999 by The American Association of Immunologists

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite Substrains

Nancy Noben-Trauth1,*, William E. Paul* and David L. Sacks{dagger}

Laboratories of * Immunology and {dagger} Parasitology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892

Using genetically pure BALB/c mice deficient in IL-4 (IL-4-/-) or IL-4 receptor {alpha}-chain (IL-4R{alpha}-/-), we have observed different disease outcomes to Leishmania major infection depending on the parasite substrain. Infection with L. major LV39 caused progressive, nonhealing ulcers and uncontrolled parasite growth in both IL-4-/- and IL-4R{alpha}-/- mice. In contrast, infection with L. major IR173 was partially controlled in IL-4-/- mice but efficiently controlled in IL-4R{alpha}-/- mice. Both IL-4-/- and IL-4R{alpha}-/- mice infected with either substrain displayed reduced Th2 responses. Surprisingly, IFN-{gamma} secretion was not up-regulated in the mutant mice, even in the IL-4R{alpha}-/- mice, which were resistant to L. major IR173. The lack of increased IFN-{gamma} production suggests that cytokine cross-regulation may not be operating in this model and that the effective ratios of Th1/Th2 cytokines become more indicative of disease outcome. The partial vs complete resistance to IR173 in IL-4-/- or IL-4R{alpha}-/- mice implies that, in addition to IL-4, IL-13 may be involved in disease progression during L. major infection. The results with LV39 infection indicate that yet another unidentified factor is capable of causing susceptibility to L. major in the absence of IL-4 or IL-4 signaling.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
W. H. Wheat, K. E. Pauken, R. V. Morris, and R. G. Titus
Lutzomyia longipalpis Salivary Peptide Maxadilan Alters Murine Dendritic Cell Expression of CD80/86, CCR7, and Cytokine Secretion and Reprograms Dendritic Cell-Mediated Cytokine Release from Cultures Containing Allogeneic T Cells
J. Immunol., June 15, 2008; 180(12): 8286 - 8298.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Salhi, V. Rodrigues Jr., F. Santoro, H. Dessein, A. Romano, L. R. Castellano, M. Sertorio, S. Rafati, C. Chevillard, A. Prata, et al.
Immunological and Genetic Evidence for a Crucial Role of IL-10 in Cutaneous Lesions in Humans Infected with Leishmania braziliensis
J. Immunol., May 1, 2008; 180(9): 6139 - 6148.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Ronet, H. Voigt, H. Himmelrich, M.-A. Doucey, Y. Hauyon-La Torre, M. Revaz-Breton, F. Tacchini-Cottier, C. Bron, J. Louis, and P. Launois
Leishmania major-Specific B Cells Are Necessary for Th2 Cell Development and Susceptibility to L. major LV39 in BALB/c Mice
J. Immunol., April 1, 2008; 180(7): 4825 - 4835.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Zhao, B. Zheng, Y. Huang, D. Yang, S. Katzman, C. Chang, D. Fowell, and W.-p. Zeng
Interaction between GATA-3 and the Transcriptional Coregulator Pias1 Is Important for the Regulation of Th2 Immune Responses
J. Immunol., December 15, 2007; 179(12): 8297 - 8304.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Nagase, K. M. Jones, C. F. Anderson, and N. Noben-Trauth
Despite Increased CD4+Foxp3+ Cells within the Infection Site, BALB/c IL-4 Receptor-Deficient Mice Reveal CD4+Foxp3-Negative T Cells as a Source of IL-10 in Leishmania major Susceptibility
J. Immunol., August 15, 2007; 179(4): 2435 - 2444.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. B. Stober, U. G. Lange, M. T. M. Roberts, A. Alcami, and J. M. Blackwell
Heterologous Priming-Boosting with DNA and Modified Vaccinia Virus Ankara Expressing Tryparedoxin Peroxidase Promotes Long-Term Memory against Leishmania major in Susceptible BALB/c Mice
Infect. Immun., February 1, 2007; 75(2): 852 - 860.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
M. C. MONTEIRO, H. C. LIMA, A. A. A. SOUZA, R. G. TITUS, P. R. T. ROMAO, and F. DE QUEIROZ CUNHA
EFFECT OF LUTZOMYIA LONGIPALPIS SALIVARY GLAND EXTRACTS ON LEUKOCYTE MIGRATION INDUCED BY LEISHMANIA MAJOR
Am J Trop Med Hyg, January 1, 2007; 76(1): 88 - 94.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. L. M. Wanderley, M. E. C. Moreira, A. Benjamin, A. C. Bonomo, and M. A. Barcinski
Mimicry of Apoptotic Cells by Exposing Phosphatidylserine Participates in the Establishment of Amastigotes of Leishmania (L) amazonensis in Mammalian Hosts
J. Immunol., February 1, 2006; 176(3): 1834 - 1839.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Holscher, B. Arendse, A. Schwegmann, E. Myburgh, and F. Brombacher
Impairment of Alternative Macrophage Activation Delays Cutaneous Leishmaniasis in Nonhealing BALB/c Mice
J. Immunol., January 15, 2006; 176(2): 1115 - 1121.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Ji, J. Masterson, J. Sun, and L. Soong
CD4+CD25+ Regulatory T Cells Restrain Pathogenic Responses during Leishmania amazonensis Infection
J. Immunol., June 1, 2005; 174(11): 7147 - 7153.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. U. Buxbaum and P. Scott
Interleukin 10- and Fc{gamma} Receptor-Deficient Mice Resolve Leishmania mexicana Lesions
Infect. Immun., April 1, 2005; 73(4): 2101 - 2108.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Bian, M. Zhong, Y. Harari, M. Lai, N. Weisbrodt, and F. Murad
From the Cover: Helminth regulation of host IL-4R{alpha}/Stat6 signaling: Mechanism underlying NOS-2 inhibition by Trichinella spiralis
PNAS, March 15, 2005; 102(11): 3936 - 3941.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. M. Theodos, R. V. Morris, J. V. Bishop, J. D. Jones, W. R. McMaster, and R. G. Titus
Characterization of an I-E-Restricted, gp63-Specific, CD4-T-Cell Clone from Leishmania major-Resistant C3H Mice That Secretes Type 2 Cytokines and Exacerbates Infection with L. major
Infect. Immun., August 1, 2004; 72(8): 4486 - 4493.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. B. Norsworthy, J. Sun, D. Elnaiem, G. Lanzaro, and L. Soong
Sand Fly Saliva Enhances Leishmania amazonensis Infection by Modulating Interleukin-10 Production
Infect. Immun., March 1, 2004; 72(3): 1240 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
U. M. Padigel, J. Alexander, and J. P. Farrell
The Role of Interleukin-10 in Susceptibility of BALB/c Mice to Infection with Leishmania mexicana and Leishmania amazonensis
J. Immunol., October 1, 2003; 171(7): 3705 - 3710.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. L. Mora, L. M. Stephenson, B. Enerson, J. Youn, A. D. Keegan, and M. Boothby
New Programming of IL-4 Receptor Signal Transduction in Activated T Cells: Stat6 Induction and Th2 Differentiation Mediated by IL-4R{alpha} Lacking Cytoplasmic Tyrosines
J. Immunol., August 15, 2003; 171(4): 1891 - 1900.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Stager, J. Alexander, K. C. Carter, F. Brombacher, and P. M. Kaye
Both Interleukin-4 (IL-4) and IL-4 Receptor {alpha} Signaling Contribute to the Development of Hepatic Granulomas with Optimal Antileishmanial Activity
Infect. Immun., August 1, 2003; 71(8): 4804 - 4807.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Noben-Trauth, R. Lira, H. Nagase, W. E. Paul, and D. L. Sacks
The Relative Contribution of IL-4 Receptor Signaling and IL-10 to Susceptibility to Leishmania major
J. Immunol., May 15, 2003; 170(10): 5152 - 5158.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. Lang, N. Courret, J.-H. Colle, G. Milon, and J.-C. Antoine
The Levels and Patterns of Cytokines Produced by CD4 T Lymphocytes of BALB/c Mice Infected with Leishmania major by Inoculation into the Ear Dermis Depend on the Infectiousness and Size of the Inoculum
Infect. Immun., May 1, 2003; 71(5): 2674 - 2683.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. Muraille, C. De Trez, B. Pajak, F. A. Torrentera, P. De Baetselier, O. Leo, and Y. Carlier
Amastigote Load and Cell Surface Phenotype of Infected Cells from Lesions and Lymph Nodes of Susceptible and Resistant Mice Infected with Leishmania major
Infect. Immun., May 1, 2003; 71(5): 2704 - 2715.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Zhang, T. Bardos, Q. Shao, J. Tschopp, K. Mikecz, T. T. Glant, and A. Finnegan
IL-4 Potentiates Activated T Cell Apoptosis Via an IL-2-Dependent Mechanism
J. Immunol., April 1, 2003; 170(7): 3495 - 3503.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
U. M. Padigel and J. P. Farrell
CD40-CD40 Ligand Costimulation Is Not Required for Initiation and Maintenance of a Th1-Type Response to Leishmania major Infection
Infect. Immun., March 1, 2003; 71(3): 1389 - 1395.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. G. J. Pollock, K. S. McNeil, J. C. Mottram, R. E. Lyons, J. M. Brewer, P. Scott, G. H. Coombs, and J. Alexander
The Leishmania mexicana Cysteine Protease, CPB2.8, Induces Potent Th2 Responses
J. Immunol., February 15, 2003; 170(4): 1746 - 1753.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. R. Johnson, R. A. Parker, J. E. Johnson, and B. S. Graham
IL-13 Is Sufficient for Respiratory Syncytial Virus G Glycoprotein-Induced Eosinophilia After Respiratory Syncytial Virus Challenge
J. Immunol., February 15, 2003; 170(4): 2037 - 2045.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. Gorelik, S. Constant, and R. A. Flavell
Mechanism of Transforming Growth Factor {beta}-induced Inhibition of T Helper Type 1 Differentiation
J. Exp. Med., June 3, 2002; 195(11): 1499 - 1505.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. L. Travi, Y. Osorio, P. C. Melby, B. Chandrasekar, L. Arteaga, and N. G. Saravia
Gender Is a Major Determinant of the Clinical Evolution and Immune Response in Hamsters Infected with Leishmania spp.
Infect. Immun., May 1, 2002; 70(5): 2288 - 2296.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. E. Jones, M. R. Ackermann, U. Wille, C. A. Hunter, and P. Scott
Early Enhanced Th1 Response after Leishmania amazonensis Infection of C57BL/6 Interleukin-10-Deficient Mice Does Not Lead to Resolution of Infection
Infect. Immun., April 1, 2002; 70(4): 2151 - 2158.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
U. M. Padigel, P. J. Perrin, and J. P. Farrell
The Development of a Th1-Type Response and Resistance to Leishmania major Infection in the Absence of CD40-CD40L Costimulation
J. Immunol., November 15, 2001; 167(10): 5874 - 5879.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
W. J. Dai, A. Hemphill, A. Waldvogel, K. Ingold, P. Deplazes, H. Mossmann, and B. Gottstein
Major Carbohydrate Antigen of Echinococcus multilocularis Induces an Immunoglobulin G Response Independent of {alpha}{beta}+ CD4+ T Cells
Infect. Immun., October 1, 2001; 69(10): 6074 - 6083.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Payet-Jamroz, S. L. T. Helm, J. Wu, M. Kilmon, M. Fakher, A. Basalp, J. G. Tew, A. K. Szakal, N. Noben-Trauth, and D. H. Conrad
Suppression of IgE Responses in CD23-Transgenic Animals Is Due to Expression of CD23 on Nonlymphoid Cells
J. Immunol., April 15, 2001; 166(8): 4863 - 4869.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. P. Mountford, K. G. Hogg, P. S. Coulson, and F. Brombacher
Signaling via Interleukin-4 Receptor {alpha} Chain Is Required for Successful Vaccination against Schistosomiasis in BALB/c Mice
Infect. Immun., January 1, 2001; 69(1): 228 - 236.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Julia, S. S. McSorley, L. Malherbe, J.-P. Breittmayer, F. Girard-Pipau, A. Beck, and N. Glaichenhaus
Priming by Microbial Antigens from the Intestinal Flora Determines the Ability of CD4+ T Cells to Rapidly Secrete IL-4 in BALB/c Mice Infected with Leishmania major
J. Immunol., November 15, 2000; 165(10): 5637 - 5645.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. R. Potter, N. Noben-Trauth, J. H. Weis, C. Teuscher, and J. J. Weis
Interleukin-4 (IL-4) and IL-13 Signaling Pathways Do Not Regulate Borrelia burgdorferi-Induced Arthritis in Mice: IgG1 Is Not Required for Host Control of Tissue Spirochetes
Infect. Immun., October 1, 2000; 68(10): 5603 - 5609.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Noben-Trauth, J. Hu-Li, and W. E. Paul
Conventional, Naive CD4+ T Cells Provide an Initial Source of IL-4 During Th2 Differentiation
J. Immunol., October 1, 2000; 165(7): 3620 - 3625.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. L. Constant, C. Dong, D. D. Yang, M. Wysk, R. J. Davis, and R. A. Flavell
JNK1 Is Required for T Cell-Mediated Immunity Against Leishmania major Infection
J. Immunol., September 1, 2000; 165(5): 2671 - 2676.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Belkaid, S. Mendez, R. Lira, N. Kadambi, G. Milon, and D. Sacks
A Natural Model of Leishmania major Infection Reveals a Prolonged ""Silent"" Phase of Parasite Amplification in the Skin Before the Onset of Lesion Formation and Immunity
J. Immunol., July 15, 2000; 165(2): 969 - 977.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
N. Sato, S. K. Ahuja, M. Quinones, V. Kostecki, R. L. Reddick, P. C. Melby, W. A. Kuziel, and S. S. Ahuja
CC Chemokine Receptor (CCR)2 Is Required for Langerhans Cell Migration and Localization of T Helper Cell Type 1 (Th1)-inducing Dendritic Cells: Absence of CCR2 Shifts the Leishmania major-resistant Phenotype to a Susceptible State Dominated by Th2 Cytokines, B Cell Outgrowth, and Sustained Neutrophilic Inflammation
J. Exp. Med., July 10, 2000; 192(2): 205 - 218.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. E. Jones, L. U. Buxbaum, and P. Scott
IL-4-Independent Inhibition of IL-12 Responsiveness During Leishmania amazonensis Infection
J. Immunol., July 1, 2000; 165(1): 364 - 372.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Ohkusu, T. Yoshimoto, K. Takeda, T. Ogura, S.-i. Kashiwamura, Y. Iwakura, S. Akira, H. Okamura, and K. Nakanishi
Potentiality of Interleukin-18 as a Useful Reagent for Treatment and Prevention of Leishmania major Infection
Infect. Immun., May 1, 2000; 68(5): 2449 - 2456.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Himmelrich, P. Launois, I. Maillard, T. Biedermann, F. Tacchini-Cottier, R. M. Locksley, M. Rocken, and J. A. Louis
In BALB/c Mice, IL-4 Production During the Initial Phase of Infection with Leishmania major Is Necessary and Sufficient to Instruct Th2 Cell Development Resulting in Progressive Disease
J. Immunol., May 1, 2000; 164(9): 4819 - 4825.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. A. Cain and G. S. Deepe Jr.
Interleukin-12 Neutralization Alters Lung Inflammation and Leukocyte Expression of CD80, CD86, and Major Histocompatibility Complex Class II in Mice Infected with Histoplasma capsulatum
Infect. Immun., April 1, 2000; 68(4): 2069 - 2076.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Jankovic, M. C. Kullberg, N. Noben-Trauth, P. Caspar, W. E. Paul, and A. Sher
Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile
J. Immunol., March 15, 2000; 164(6): 3047 - 3055.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. J. Matthews, C. L. Emson, G. J. McKenzie, H. E. Jolin, J. M. Blackwell, and A. N. J. McKenzie
IL-13 Is a Susceptibility Factor for Leishmania major Infection
J. Immunol., February 1, 2000; 164(3): 1458 - 1462.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
F. P. Heinzel and R. A. Maier Jr.
Interleukin-4-Independent Acceleration of Cutaneous Leishmaniasis in Susceptible BALB/c Mice following Treatment with Anti-CTLA4 Antibody
Infect. Immun., December 1, 1999; 67(12): 6454 - 6460.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. L. Dent, T. M. Doherty, W. E. Paul, A. Sher, and L. M. Staudt
BCL-6-Deficient Mice Reveal an IL-4-Independent, STAT6-Dependent Pathway That Controls Susceptibility to Infection by Leishmania major
J. Immunol., August 15, 1999; 163(4): 2098 - 2103.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.