| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Division of Gastroenterology-Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242;
Department of Pathology, University of Wisconsin, Madison, WI 53792; and
Children’s Hospital and Department of Medicine, Beth Israel Hospital, Boston, MA 02215
Immune cells within the granulomas of murine schistosomiasis
mansoni make the neuropeptide substance P (SP) and express neurokine 1
receptor, which is the specific receptor for substance P (SPr). It was
determined if mice with deletion of the SPr (SPr-/-)
would develop a normal granulomatous response to schistosome ova during
the course of natural infection. Mean liver granuloma size was smaller
in SPr-/- mice compared with that of wild-type control
animals. Although flow analysis revealed little difference in the
cellular composition of the granulomas, both splenocytes and granuloma
cells from SPr-/- mice produced much less IFN-
and
IgG2a and less IgE. The expression of Th2 cytokines (IL-4/IL-5) and
IgG1 was comparable to the wild-type control. The mouse with targeted
disruption of its SPr had the nonmammalian gene encoding the enzyme
ß-galactosidase inserted in exon 1 of the SPr gene. There was
ß-galactosidase activity in many mononuclear cells scattered
throughout the schistosome granulomas of SPr-/- mice.
Also, a granuloma T cell line derived from this transgenic mouse
produced ß-galactosidase. These results provide further evidence that
in murine schistosomiasis SPr is displayed commonly on granuloma
inflammatory cells and is important for granuloma development and
expression of IFN- circuitry in this natural
infection.
This article has been cited by other articles:
|
|
 |
|
  M. Dib, Z. Zsengeller, A. Mitsialis, B. Lu, S. Craig, C. Gerard, and N. P. Gerard A paradoxical protective role for the proinflammatory peptide substance P receptor (NK1R) in acute hyperoxic lung injury Am J Physiol Lung Cell Mol Physiol, October 1, 2009; 297(4): L687 - L697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Blum, T. Setiawan, L. Hang, K. Stoyanoff, and J. V. Weinstock Interleukin-12 (IL-12) and IL-23 Induction of Substance P Synthesis in Murine T Cells and Macrophages Is Subject to IL-10 and Transforming Growth Factor {beta} Regulation Infect. Immun., August 1, 2008; 76(8): 3651 - 3656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. S. Chauhan, D. G. Sterka Jr., D. L. Gray, K. L. Bost, and I. Marriott Neurogenic Exacerbation of Microglial and Astrocyte Responses to Neisseria meningitidis and Borrelia burgdorferi J. Immunol., June 15, 2008; 180(12): 8241 - 8249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Arsenescu, A. M. Blum, A. Metwali, D. E. Elliott, and J. V. Weinstock IL-12 Induction of mRNA Encoding Substance P in Murine Macrophages from the Spleen and Sites of Inflammation J. Immunol., April 1, 2005; 174(7): 3906 - 3911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Metwali, A. M. Blum, D. E. Elliott, T. Setiawan, and J. V. Weinstock Cutting Edge: Hemokinin Has Substance P-Like Function and Expression in Inflammation J. Immunol., June 1, 2004; 172(11): 6528 - 6532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rasley, I. Marriott, C. R. Halberstadt, K. L. Bost, and J. Anguita Substance P Augments Borrelia burgdorferi-Induced Prostaglandin E2 Production by Murine Microglia J. Immunol., May 1, 2004; 172(9): 5707 - 5713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Stavitsky Regulation of Granulomatous Inflammation in Experimental Models of Schistosomiasis Infect. Immun., January 1, 2004; 72(1): 1 - 12. [Full Text] [PDF]
|
|
|
|
|
|
J. V. Weinstock, A. Blum, A. Metwali, D. Elliott, N. Bunnett, and R. Arsenescu Substance P Regulates Th1-Type Colitis in IL-10 Knockout Mice J. Immunol., October 1, 2003; 171(7): 3762 - 3767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. V. Weinstock, A. Blum, A. Metwali, D. Elliott, and R. Arsenescu IL-18 and IL-12 Signal Through the NF-{kappa}B Pathway to Induce NK-1R Expression on T Cells J. Immunol., May 15, 2003; 170(10): 5003 - 5007. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bang, G. Sass, A. K. Kiemer, A. M. Vollmar, W. L. Neuhuber, and G. Tiegs Neurokinin-1 Receptor Antagonists CP-96,345 and L-733,060 Protect Mice from Cytokine-Mediated Liver Injury J. Pharmacol. Exp. Ther., April 1, 2003; 305(1): 31 - 39. [Abstract] [Full Text]
|
|
|
|
|
|
S. F. Elsawa, W. Taylor, C. C. Petty, I. Marriott, J. V. Weinstock, and K. L. Bost Reduced CTL Response and Increased Viral Burden in Substance P Receptor-Deficient Mice Infected with Murine {gamma}-Herpesvirus 68 J. Immunol., March 1, 2003; 170(5): 2605 - 2612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Blum, A. Metwali, D. E. Elliott, and J. V. Weinstock T cell substance P receptor governs antigen-elicited IFN-gamma production Am J Physiol Gastrointest Liver Physiol, February 1, 2003; 284(2): G197 - G204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Robinson, A. C. White, D. E. Lewis, J. Thornby, E. David, and J. Weinstock Sequential Expression of the Neuropeptides Substance P and Somatostatin in Granulomas Associated with Murine Cysticercosis Infect. Immun., August 1, 2002; 70(8): 4534 - 4538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Sonea, M. V. Palmer, D. Akili, and J. A. Harp Treatment with Neurokinin-1 Receptor Antagonist Reduces Severity of Inflammatory Bowel Disease Induced by Cryptosporidium parvum Clin. Vaccine Immunol., March 1, 2002; 9(2): 333 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. BLUM, A. METWALI, C. CRAWFORD, J. LI, K. QADIR, D. E. ELLIOTT, and J. V. WEINSTOCK Interleukin 12 and antigen independently induce substance P receptor expression in T cells in murine schistosomiasis mansoni FASEB J, April 1, 2001; 15(6): 950 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Jacoby, B. L. Yost, T. Elwood, and A. D. Fryer Effects of neurokinin receptor antagonists in virus-infected airways Am J Physiol Lung Cell Mol Physiol, July 1, 2000; 279(1): L59 - L65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Marriott and K. L. Bost IL-4 and IFN-{gamma} Up-Regulate Substance P Receptor Expression in Murine Peritoneal Macrophages J. Immunol., July 1, 2000; 165(1): 182 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. G. Hammond, R. Saban, K. L. Bost, H. W. Harris Jr., J. H. Kaysen, F. O. Goda, X.-C. Wang, F. C. Lewis, G. L. Navar, W. C. Campbell, et al. Substance P dependence of endosomal fusion during bladder inflammation Am J Physiol Renal Physiol, March 1, 2000; 278(3): F440 - F451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Saban, M. R. Saban, N.-B. Nguyen, B. Lu, C. Gerard, N. P. Gerard, and T. G. Hammond Neurokinin-1 (NK-1) Receptor Is Required in Antigen-Induced Cystitis Am. J. Pathol., March 1, 2000; 156(3): 775 - 780. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
