| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of
*
Pathology and
Internal Medicine, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109; and
National Institute of Aging, National Institutes of Health, Baltimore, MD 21224
The immunomodulatory role of the chemokine C10 was explored in
allergic airway responses during experimental allergic bronchopulmonary
aspergillosis (ABPA). The intratracheal delivery of Asperigillus
fumigatus Ag into A. fumigatus-sensitized mice
resulted in significantly increased levels of C10 within the
bronchoalveolar lavage, and these levels peaked at 48 h after
A. fumigatus challenge. In addition, C10 levels in BAL
samples were greater than 5-fold higher than levels of other chemokines
such as monocyte-chemoattractant protein-1, eotaxin, and
macrophage-inflammatory protein-1
. From in vitro studies, it was
evident that major pulmonary sources of C10 may have included alveolar
macrophages, lung fibroblasts, and vascular smooth muscle cells.
Experimental ABPA was associated with severe peribronchial
eosinophilia, bronchial hyperresponsiveness, and augmented IL-13 and
IgE levels. The immunoneutralization of C10 with polyclonal
anti-C10 antiserum 2 h before the intratracheal A.
fumigatus challenge significantly reduced the airway
inflammation and hyperresponsiveness in this model of ABPA, but had no
effect on IL-10 nor IgE levels. Taken together, these data suggest that
C10 has a unique role in the progression of experimental
ABPA.
This article has been cited by other articles:
|
|
 |
|
  K. Shimizu, M. Minami, R. Shubiki, M. Lopez-Ilasaca, L. MacFarlane, Y. Asami, Y. Li, R. N. Mitchell, and P. Libby CC Chemokine Receptor-1 Activates Intimal Smooth Muscle-Like Cells in Graft Arterial Disease Circulation, November 3, 2009; 120(18): 1800 - 1813. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Schaller, R. Neupane, B. D. Rudd, S. L. Kunkel, L. E. Kallal, P. Lincoln, J. B. Lowe, Y. Man, and N. W. Lukacs Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines J. Exp. Med., November 26, 2007; 204(12): 2925 - 2934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Coelho, M. A. Schaller, C. F. Benjamim, A. Z. Orlofsky, C. M. Hogaboam, and S. L. Kunkel The Chemokine CCL6 Promotes Innate Immunity via Immune Cell Activation and Recruitment J. Immunol., October 15, 2007; 179(8): 5474 - 5482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Mitchell and P. Libby Vascular Remodeling in Transplant Vasculopathy Circ. Res., April 13, 2007; 100(7): 967 - 978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Beaty, C. E. Rose Jr., and S.-s. J. Sung Diverse and Potent Chemokine Production by Lung CD11bhigh Dendritic Cells in Homeostasis and in Allergic Lung Inflammation J. Immunol., February 1, 2007; 178(3): 1882 - 1895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Berahovich, Z. Miao, Y. Wang, B. Premack, M. C. Howard, and T. J. Schall Proteolytic Activation of Alternative CCR1 Ligands in Inflammation J. Immunol., June 1, 2005; 174(11): 7341 - 7351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ma, Z. Zhu, R. J. Homer, C. Gerard, R. Strieter, and J. A. Elias The C10/CCL6 Chemokine and CCR1 Play Critical Roles in the Pathogenesis of IL-13-Induced Inflammation and Remodeling J. Immunol., February 1, 2004; 172(3): 1872 - 1881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. P. Oliveira, D. D. Taub, J. Nagel, R. Smith, C. M. Hogaboam, A. Berlin, and N. W. Lukacs Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis Blood, December 15, 2002; 100(13): 4291 - 4297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Belperio, M. Dy, M. D. Burdick, Y. Y. Xue, K. Li, J. A. Elias, and M. P. Keane Interaction of IL-13 and C10 in the Pathogenesis of Bleomycin-Induced Pulmonary Fibrosis Am. J. Respir. Cell Mol. Biol., October 1, 2002; 27(4): 419 - 427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Schuh, K. Blease, S. L. Kunkel, and C. M. Hogaboam Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L198 - L204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhu, B. Ma, T. Zheng, R. J. Homer, C. G. Lee, I. F. Charo, P. Noble, and J. A. Elias IL-13-Induced Chemokine Responses in the Lung: Role of CCR2 in the Pathogenesis of IL-13-Induced Inflammation and Remodeling J. Immunol., March 15, 2002; 168(6): 2953 - 2962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Blease, C. Jakubzick, J. M. Schuh, B. H. Joshi, R. K. Puri, and C. M. Hogaboam IL-13 Fusion Cytotoxin Ameliorates Chronic Fungal-Induced Allergic Airway Disease in Mice J. Immunol., December 1, 2001; 167(11): 6583 - 6592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Tekkanat, H. Maassab, A. A. Berlin, P. M. Lincoln, H. L. Evanoff, M. H. Kaplan, and N. W. Lukacs Role of Interleukin-12 and Stat-4 in the Regulation of Airway Inflammation and Hyperreactivity in Respiratory Syncytial Virus Infection Am. J. Pathol., August 1, 2001; 159(2): 631 - 638. [Abstract] [Full Text]
|
|
|
|
|
|
N. W. Lukacs, K. K. Tekkanat, A. Berlin, C. M. Hogaboam, A. Miller, H. Evanoff, P. Lincoln, and H. Maassab Respiratory Syncytial Virus Predisposes Mice to Augmented Allergic Airway Responses Via IL-13-Mediated Mechanisms J. Immunol., July 15, 2001; 167(2): 1060 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Klein, A. Talvani, P. M. R. Silva, M. A. Martins, T. N. C. Wells, A. Proudfoot, N. W. Luckacs, and M. M. Teixeira Stem Cell Factor-Induced Leukotriene B4 Production Cooperates with Eotaxin to Mediate the Recruitment of Eosinophils During Allergic Pleurisy in Mice J. Immunol., July 1, 2001; 167(1): 524 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Blease, C. Jakubzick, J. Westwick, N. Lukacs, S. L. Kunkel, and C. M. Hogaboam Therapeutic Effect of IL-13 Immunoneutralization During Chronic Experimental Fungal Asthma J. Immunol., April 15, 2001; 166(8): 5219 - 5224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Matsukawa, M. H. Kaplan, C. M. Hogaboam, N. W. Lukacs, and S. L. Kunkel Pivotal Role of Signal Transducer and Activator of Transcription (Stat)4 and Stat6 in the Innate Immune Response during Sepsis J. Exp. Med., March 19, 2001; 193(6): 679 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Tekkanat, H. F. Maassab, D. S. Cho, J. J. Lai, A. John, A. Berlin, M. H. Kaplan, and N. W. Lukacs IL-13-Induced Airway Hyperreactivity During Respiratory Syncytial Virus Infection Is STAT6 Dependent J. Immunol., March 1, 2001; 166(5): 3542 - 3548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Ajuebor, C. M. Hogaboam, S. L. Kunkel, A. E. I. Proudfoot, and J. L. Wallace The Chemokine RANTES Is a Crucial Mediator of the Progression from Acute to Chronic Colitis in the Rat J. Immunol., January 1, 2001; 166(1): 552 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Steinhauser, C. M. Hogaboam, A. Matsukawa, N. W. Lukacs, R. M. Strieter, and S. L. Kunkel Chemokine C10 Promotes Disease Resolution and Survival in an Experimental Model of Bacterial Sepsis Infect. Immun., November 1, 2000; 68(11): 6108 - 6114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Blease, B. Mehrad, T. J. Standiford, N. W. Lukacs, J. Gosling, L. Boring, I. F. Charo, S. L. Kunkel, and C. M. Hogaboam Enhanced Pulmonary Allergic Responses to Aspergillus in CCR2-/- Mice J. Immunol., September 1, 2000; 165(5): 2603 - 2611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Blease, B. Mehrad, T. J. Standiford, N. W. Lukacs, S. L. Kunkel, S. W. Chensue, B. Lu, C. J. Gerard, and C. M. Hogaboam Airway Remodeling Is Absent in CCR1-/- Mice During Chronic Fungal Allergic Airway Disease J. Immunol., August 1, 2000; 165(3): 1564 - 1572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Panoskaltsis-Mortari, R. M. Strieter, J. R. Hermanson, K. V. Fegeding, W. J. Murphy, C. L. Farrell, D. L. Lacey, and B. R. Blazar Induction of monocyte- and T-cell-attracting chemokines in the lung during the generation of idiopathic pneumonia syndrome following allogeneic murine bone marrow transplantation Blood, August 1, 2000; 96(3): 834 - 839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Todt, J. Sonstein, T. Polak, G. D. Seitzman, B. Hu, and J. L. Curtis Repeated Intratracheal Challenge with Particulate Antigen Modulates Murine Lung Cytokines ,2 J. Immunol., April 15, 2000; 164(8): 4037 - 4047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Hogaboam, K. Blease, B. Mehrad, M. L. Steinhauser, T. J. Standiford, S. L. Kunkel, and N. W. Lukacs Chronic Airway Hyperreactivity, Goblet Cell Hyperplasia, and Peribronchial Fibrosis during Allergic Airway Disease Induced by Aspergillus fumigatus Am. J. Pathol., February 1, 2000; 156(2): 723 - 732. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
