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ChT1, an Ig Superfamily Molecule Required for T Cell Differentiation^{1 ,2}

Kaisa Katevuo^3,*, Beat A. Imhof, Richard Boyd, Ann Chidgey, Andrew Bean, Dominique Dunon^§, Thomas W. F. Göbel^¶ and Olli Vainio^*

^* Turku Immunology Center, Department of Medical Microbiology, University of Turku, Turku, Finland; Department of Pathology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland; Department of Pathology and Immunology, Monash University Medical School, Prahran, Melbourne, Victoria, Australia; ^§ Unité de Recherche Associée-Centre National de la Recherche Scientifique 1135, University of Pierre and Marie Curie, Paris, France; and ^¶ Basel Institute for Immunology, Basel, Switzerland

The thymus is colonized by circulating progenitor cells that differentiate into mature T cells under the influence of the thymic microenvironment. We report here the cloning and function of the avian thymocyte Ag ChT1, a member of the Ig superfamily with one V-like and one C2-like domain. ChT1-positive embryonic bone marrow cells coexpressing c-kit give rise to mature T cells upon intrathymic cell transfer. ChT1-specific Ab inhibits T cell differentiation in embryonic thymic organ cultures and in thymocyte precursor cocultures on stromal cells. Thus, we provide clear evidence that ChT1 is a novel Ag on early T cell progenitors that plays an important role in the early stages of T cell development.

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