| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
*
Departamento de Inmunología y Oncología, Centro Nacional de Biotecnología, Universidad Autónoma de Madrid, Madrid, Spain; and
Departamento de Biología Celular, Facultad de Biología, Universidad Complutense, Madrid, Spain
Thymus-expressed chemokine (TECK) has been reported to chemoattract dendritic cells, thymocytes, and activated macrophages. Here, we show that TECK is a specific agonist for a human orphan receptor called GPR-9-6. We have determined the cDNA sequence of human GPR-9-6 and cloned the corresponding murine cDNA. Human and murine GPR-9-6 expression is very high in the thymus and low in lymph nodes and spleen. RT-PCR analysis of murine GPR-9-6 expression on murine FACS-sorted thymocyte subpopulations showed that this gene is expressed in both immature and mature T cells. Additions of human or murine TECK to HEK 293/human GPR-9-6 and HEK 293/murine GPR-9-6 transfectants provoked intracytoplasmic calcium mobilization. Human TECK also induced the in vitro migration of HEK 293/human GPR-9-6 cells. These results confirm that GPR-9-6 is a specific receptor for TECK. According to the established nomenclature system, we propose to rename GPR-9-6 as CC chemokine receptor 9 (CCR9).
This article has been cited by other articles:
|
|
 |
|
  M. Parmo-Cabanas, D. Garcia-Bernal, R. Garcia-Verdugo, L. Kremer, G. Marquez, and J. Teixido Intracellular signaling required for CCL25-stimulated T cell adhesion mediated by the integrin {alpha}4{beta}1 J. Leukoc. Biol., August 1, 2007; 82(2): 380 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Schwarz, A. Sambandam, I. Maillard, B. C. Harman, P. E. Love, and A. Bhandoola Selective Thymus Settling Regulated by Cytokine and Chemokine Receptors J. Immunol., February 15, 2007; 178(4): 2008 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Knoechel, J. Lohr, S. Zhu, L. Wong, D. Hu, L. Ausubel, and A. K. Abbas Functional and Molecular Comparison of Anergic and Regulatory T Lymphocytes. J. Immunol., June 1, 2006; 176(11): 6473 - 6483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Alejo, M. B. Ruiz-Arguello, Y. Ho, V. P. Smith, M. Saraiva, and A. Alcami A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus PNAS, April 11, 2006; 103(15): 5995 - 6000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Garcia-Ojeda, S. Dejbakhsh-Jones, D. Chatterjea-Matthes, A. Mukhopadhyay, A. BitMansour, I. L. Weissman, J. M. Y. Brown, and S. Strober Stepwise Development of Committed Progenitors in the Bone Marrow That Generate Functional T Cells in the Absence of the Thymus J. Immunol., October 1, 2005; 175(7): 4363 - 4373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Henson, R. Snelgrove, T. Hussell, D. J. Wells, and R. Aspinall An IL-7 Fusion Protein That Shows Increased Thymopoietic Ability J. Immunol., September 15, 2005; 175(6): 4112 - 4118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Benz and C. C. Bleul A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision J. Exp. Med., July 5, 2005; 202(1): 21 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Singh, U. P. Singh, J. K. Stiles, W. E. Grizzle, and J. W. Lillard Jr. Expression and Functional Role of CCR9 in Prostate Cancer Cell Migration and Invasion Clin. Cancer Res., December 15, 2004; 10(24): 8743 - 8750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Qiuping, X. Jei, J. Youxin, J. Wei, L. Chun, W. Jin, W. Qun, L. Yan, H. Chunsong, Y. Mingzhen, et al. CC Chemokine Ligand 25 Enhances Resistance to Apoptosis in CD4+ T Cells from Patients with T-Cell Lineage Acute and Chronic Lymphocytic Leukemia by Means of Livin Activation Cancer Res., October 15, 2004; 64(20): 7579 - 7587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ueda, K. Yang, S. J. Foster, M. Kondo, and G. Kelsoe Inflammation Controls B Lymphopoiesis by Regulating Chemokine CXCL12 Expression J. Exp. Med., January 5, 2004; 199(1): 47 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Qiuping, L. Qun, H. Chunsong, Z. Xiaolian, H. Baojun, Y. Mingzhen, L. Chengming, H. Jinshen, G. Qingping, Z. Kejian, et al. Selectively Increased Expression and Functions of Chemokine Receptor CCR9 on CD4+ T Cells from Patients with T-Cell Lineage Acute Lymphocytic Leukemia Cancer Res., October 1, 2003; 63(19): 6469 - 6477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Onai, M. Kitabatake, Y.-y. Zhang, H. Ishikawa, S. Ishikawa, and K. Matsushima Pivotal role of CCL25 (TECK)-CCR9 in the formation of gut cryptopatches and consequent appearance of intestinal intraepithelial T lymphocytes Int. Immunol., July 1, 2002; 14(7): 687 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Uehara, A. Grinberg, J. M. Farber, and P. E. Love A Role for CCR9 in T Lymphocyte Development and Migration J. Immunol., March 15, 2002; 168(6): 2811 - 2819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Uehara, K. Song, J. M. Farber, and P. E. Love Characterization of CCR9 Expression and CCL25/Thymus-Expressed Chemokine Responsiveness During T Cell Development: CD3highCD69+ Thymocytes and {gamma}{delta}TCR+ Thymocytes Preferentially Respond to CCL25 J. Immunol., January 1, 2002; 168(1): 134 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-A. Wurbel, M. Malissen, D. Guy-Grand, E. Meffre, M. C. Nussenzweig, M. Richelme, A. Carrier, and B. Malissen Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gamma delta + gut intraepithelial lymphocytes Blood, November 1, 2001; 98(9): 2626 - 2632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-S. Youn, Y. J. Kim, C. Mantel, K.-Y. Yu, and H. E. Broxmeyer Blocking of c-FLIPL-independent cycloheximide-induced apoptosis or Fas-mediated apoptosis by the CC chemokine receptor 9/TECK interaction Blood, August 15, 2001; 98(4): 925 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wilbanks, S. C. Zondlo, K. Murphy, S. Mak, D. Soler, P. Langdon, D. P. Andrew, L. Wu, and M. Briskin Expression Cloning of the STRL33/BONZO/TYMSTR Ligand Reveals Elements of CC, CXC, and CX3C Chemokines J. Immunol., April 15, 2001; 166(8): 5145 - 5154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Carramolino, A. Zaballos, L. Kremer, R. Villares, P. Martin, C. Ardavin, C. Martinez-A, and G. Marquez Expression of CCR9 {beta}-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8+ T cells from secondary lymphoid organs Blood, February 15, 2001; 97(4): 850 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Romagnani, F. Annunziato, E. Lazzeri, L. Cosmi, C. Beltrame, L. Lasagni, G. Galli, M. Francalanci, R. Manetti, F. Marra, et al. Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) {alpha}{beta}+CD8+ single-positive T cells, TCR{gamma}{delta}+ T cells, and natural killer-type cells in human thymus Blood, February 1, 2001; 97(3): 601 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Papadakis, J. Prehn, V. Nelson, L. Cheng, S. W. Binder, P. D. Ponath, D. P. Andrew, and S. R. Targan The Role of Thymus-Expressed Chemokine and Its Receptor CCR9 on Lymphocytes in the Regional Specialization of the Mucosal Immune System J. Immunol., November 1, 2000; 165(9): 5069 - 5076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Krzysiek, E. A. Lefevre, J. Bernard, A. Foussat, P. Galanaud, F. Louache, and Y. Richard Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha /CCL20 in human B cells Blood, October 1, 2000; 96(7): 2338 - 2345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yang, Q. Chen, S. Stoll, X. Chen, O. M. Z. Howard, and J. J. Oppenheim Differential Regulation of Responsiveness to fMLP and C5a Upon Dendritic Cell Maturation: Correlation with Receptor Expression J. Immunol., September 1, 2000; 165(5): 2694 - 2702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. M. Z. Howard, H. F. Dong, A.-K. Shirakawa, and J. J. Oppenheim LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8 Blood, August 1, 2000; 96(3): 840 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Annunziato, P. Romagnani, L. Cosmi, C. Beltrame, B. H. Steiner, E. Lazzeri, C. J. Raport, G. Galli, R. Manetti, C. Mavilia, et al. Macrophage-Derived Chemokine and EBI1-Ligand Chemokine Attract Human Thymocytes in Different Stage of Development and Are Produced by Distinct Subsets of Medullary Epithelial Cells: Possible Implications for Negative Selection J. Immunol., July 1, 2000; 165(1): 238 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Murdoch and A. Finn Chemokine receptors and their role in inflammation and infectious diseases Blood, May 15, 2000; 95(10): 3032 - 3043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Scoggins, J. R. Taylor Jr., J. Patrie, A. B. van't Wout, H. Schuitemaker, and D. Camerini Pathogenesis of Primary R5 Human Immunodeficiency Virus Type 1 Clones in SCID-hu Mice J. Virol., April 1, 2000; 74(7): 3205 - 3216. [Abstract] [Full Text]
|
|
|
|
|
|
D. I. Jarmin, M. Rits, D. Bota, N. P. Gerard, G. J. Graham, I. Clark-Lewis, and C. Gerard Cutting Edge: Identification of the Orphan Receptor G-Protein-Coupled Receptor 2 as CCR10, a Specific Receptor for the Chemokine ESkine J. Immunol., April 1, 2000; 164(7): 3460 - 3464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gosling, D. J. Dairaghi, Y. Wang, M. Hanley, D. Talbot, Z. Miao, and T. J. Schall Cutting Edge: Identification of a Novel Chemokine Receptor That Binds Dendritic Cell- and T Cell-Active Chemokines Including ELC, SLC, and TECK J. Immunol., March 15, 2000; 164(6): 2851 - 2856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors Pharmacol. Rev., March 1, 2000; 52(1): 145 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-R. Yu, K. W. C. Peden, M. B. Zaitseva, H. Golding, and J. M. Farber CCR9A and CCR9B: Two Receptors for the Chemokine CCL25/TECK/Ck{beta}-15 That Differ in Their Sensitivities to Ligand J. Immunol., February 1, 2000; 164(3): 1293 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Norment, L. Y. Bogatzki, B. N. Gantner, and M. J. Bevan Murine CCR9, a Chemokine Receptor for Thymus-Expressed Chemokine That Is Up-Regulated Following Pre-TCR Signaling J. Immunol., January 15, 2000; 164(2): 639 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Zabel, W. W. Agace, J. J. Campbell, H. M. Heath, D. Parent, A. I. Roberts, E. C. Ebert, N. Kassam, S. Qin, M. Zovko, et al. Human G Protein-Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine-Mediated Chemotaxis J. Exp. Med., November 1, 1999; 190(9): 1241 - 1256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-S. Youn, C. H. Kim, F. O. Smith, and H. E. Broxmeyer TECK, an Efficacious Chemoattractant for Human Thymocytes, Uses GPR-9-6/CCR9 as a Specific Receptor Blood, October 1, 1999; 94(7): 2533 - 2536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Wang, H. Soto, E. R. Oldham, M. E. Buchanan, B. Homey, D. Catron, N. Jenkins, N. G. Copeland, D. J. Gilbert, N. Nguyen, et al. Identification of a Novel Chemokine (CCL28), which Binds CCR10 (GPR2) J. Biol. Chem., July 14, 2000; 275(29): 22313 - 22323. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
