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CUTTING EDGE |
-Chain1
Basel Institute for Immunology, Basel, Switzerland
Ig-like transcripts (ILTs) encode cell surface receptors
expressed on myeloid and lymphoid cells that are structurally and
functionally related to killer cell inhibitory receptors. One ILT,
designated ILT1, contains a short cytoplasmic domain that lacks
sequence motifs implicated in signal transduction. Its function is
unknown. Similar short cytoplasmic domains have been observed in
activating NK cell receptors and Fc
R, which transduce stimulatory
signals via associated DAP12 and Fc
RI
proteins, respectively.
Here we show that ILT1 receptor is selectively expressed on myeloid
cells, functions as an activating receptor, and associates with
FcRI rather than DAP12.
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